Positive family history of prostate cancer not associated with worse outcomes after radical prostatectomy

Lee, Keith L.; Marotte, Jeffrey B.; Ferrari, Michelle; McNeal, John E.; Brooks, James D.; Presti, Joseph C.

doi:10.1016/j.urology.2004.09.005

Cited by 22 publications

(24 citation statements)

References 21 publications

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“…A Japanese registry study found that patients with colorectal cancer and a family history had a better prognosis as compared to those without a family history [25], but other studies found no effect of family history on outcomes from colorectal cancer [26][27][28]. Some studies in prostate cancer have suggested a more aggressive clinical course for familial prostate cancers [29,30], while others have found no effect of a positive family history on prostate cancer outcomes [31,32]. Breast cancer studies demonstrated no effect of family history on overall prognosis [33,34] in some series, but other reports in patients with pre-menopausal breast cancer have suggested a better prognosis, especially in instances of an affected first-degree relative [35,36].…”

Section: Discussionmentioning

confidence: 99%

Association of positive family history with survival of patients with lung cancer

Ganti¹,

Loberiza²,

Kessinger³

2009

Lung Cancer

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Section: Discussionmentioning

confidence: 99%

Association of positive family history with survival of patients with lung cancer

Ganti¹,

Loberiza²,

Kessinger³

2009

Lung Cancer

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“…The causes of familial and sporadic cancers may differ and many studies have examined the possible differences in survival, however, overall with inconclusive results. For the commonest cancers, such as prostate and breast cancers, recent evidence has suggested no survival difference between the sporadic and familial diseases [3][4][5][6][7][8][9][10][11][12][13][14][15][16]. A similar survival experience was noted for familial and sporadic cancers for most of the cancer sites examined.…”

Section: Discussionmentioning

confidence: 64%

“…Many other studies have been done to examine the survival difference between familial and sporadic cancers, such as breast and prostate cancers [3][4][5][6][7][8][9][10][11][12][13][14][15][16]. However, the results were inconsistent at present, and study design limitations, such as such as small sample size, biased selection of study subjects and poor selection of controls, could be related to the inconsistent data.…”

Section: Introductionmentioning

confidence: 99%

Survival in common cancers defined by risk and survival of family members

Försti

Sundquist

et al. 2010

Oncol Rev

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Studies on survival between familial and sporadic cancers have been inconclusive and only recent data on a limited number of cancers are available on the concordance of survival between family members. In this review, we address these questions by evaluating the published and unpublished data from the nation-wide Swedish Family-Cancer Database and a total of 13 cancer sites were assessed. Using sporadic cancer as reference, HRs were close to 1.0 for most of the familial cancers in both the offspring and parental generations, which suggested that survival in patients with familial and sporadic cancers was equal, with an exception for ovarian cancer with a worse prognosis. Compared to offspring whose parents had a poor survival, those with a good parental survival had a decreased risk of death for most cancers and HR was significantly decreased for cancers in the breast, prostate, bladder, and kidney. For colorectal and nervous system cancers, favorable survival between the generations showed a borderline significance. These data are consistent in showing that both good and poor survival in certain cancers aggregate in families. Genetic factors are likely to contribute to the results. These observations call for intensified efforts to consider heritability in survival as one mechanism regulating prognosis in cancer patients.

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“…Kupelian et al reported that there were no associations between the presence of a family history of PCa and any demographic, clinical, or treatment factors, except age [10]. Lee et al performed a retrospective analysis of 557 men with localized PCa who were treated by radical prostatectomy and showed that the NSPC patients were younger at the time of surgery than were the SPC patients [11]. Roemeling et al analyzed the characteristics of NSPC by use of the screening arm of the Rotterdam section of the European Randomized Study of Screening for Prostate Cancer and reported that the cancer detection rate in 1,364 men with a positive family history was 7.7% (106 cancers in 1,364 screened men with a positive family history) in the prevalence screen, whereas the positive predictive value of biopsies was 32.2% (154 cancers in 532 biopsies) [12].…”

Section: Discussionmentioning

confidence: 99%

Clinical Features of Familial or Hereditary Prostate Cancer in Korean Men: A Pilot Study

et al. 2011

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PurposeThere are few data regarding the epidemiology of hereditary or familial prostate cancer (PCa) in East Asians, especially in Korean men. Therefore, we evaluated the incidence of familial and hereditary PCa and the relation between socioeconomic status and the incidence of nonsporadic prostate cancer (NSPC).Materials and MethodsWe collected data from all patients who were treated for PCa at our center between November 2009 and January 2010. All patients were either newly diagnosed or had been diagnosed with PCa and seen as outpatients during the study period.ResultsIn a sample of 218 patients with PCa; 25 (11.5%) were NSPC patients, and 193 (88.6%) were sporadic PCa sporadic prostate cancer (SPC) patients. Overall, 11.5% of the patients had a positive family history. There was one hereditary PCa family (three patients, 1.4%) and 11 familial PCa families (22 patients, 10.1%). Patients were divided into three different age groups. Of these, 18 (9.3%) SPC patients and 6 (24%) NSPC patients were diagnosed with the disease at the age of 55 years or younger (p=0.02). Prostate-specific antigen (PSA) levels in the NSPC group were significantly higher than in the SPC group (7.2±3.2 versus 6.3±4.9 ng/ml, p=0.042). SPC patients had larger waist circumferences than did NSPC patients (p=0.041). There were no significant differences between the SPC and NSPC groups in terms of socioeconomic status, Gleason score, pathological stage, or pathologic Gleason grade.ConclusionsEast Asian NSPC patients are diagnosed at earlier ages than are SPC patients, even though the incidence of NSPC in the East Asian population is lower than in Western men.

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Positive family history of prostate cancer not associated with worse outcomes after radical prostatectomy

Cited by 22 publications

References 21 publications

Association of positive family history with survival of patients with lung cancer

Association of positive family history with survival of patients with lung cancer

Survival in common cancers defined by risk and survival of family members

Clinical Features of Familial or Hereditary Prostate Cancer in Korean Men: A Pilot Study

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