Positive feedback action of pituitary β-Endorphin on acupuncture analgesia afferent pathway

Takeshige, Chifuyu; Nakamura, Atushi; Asamoto, Shunji; Arai, T.

doi:10.1016/0361-9230(92)90006-j

Cited by 35 publications

(21 citation statements)

References 14 publications

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“…In 10 studies, percentage changes in pain behavior (from baseline) were calculated: cut-off values in the responder ranged 10–150% increase in TFL or the pressure pain threshold, and those in the non-responders were 0–50%. Three studies defined responders as animals exhibiting statistically significant increases in TFL ( p < 0.05) compared with baseline [20, 21, 28]. One study defined a non-responder as an animal in which the TFL change was less than the mean value plus three standard deviations [24].…”

Section: Resultsmentioning

confidence: 99%

“…Takeshige et al showed that the evoked potential in the posterior arcuate nucleus of hypothalamus and the dorsal periaqueductal gray matter of responders differed from that of non-responders [20, 21]. They also reported that administration of morphine (i.p.…”

Section: Resultsmentioning

confidence: 99%

“…They also reported that administration of morphine (i.p. or microinjection into posterior arcuate nucleus of hypothalamus) increased the anti-nociceptive effects of EA to a level similar to high responders [20], whereas acupuncture- induced anti-nociception in responders remained unchanged. Both modulation of met-enkephalin [21] and β-endorphin [20, 21] could also convert the response of EA.…”

Section: Resultsmentioning

confidence: 99%

“…Low responsiveness to EA effects was known to be associated with changes in cholecystokinin (CCK) levels [19]. It was also suggested that the degree of responsiveness to acupuncture effects was associated with different neural activation by EA in periaqueductal grey (PAG) or hypothalamus [20, 21]. Thus, further work on the mechanisms involved and specific regulation of intrinsic factors related with high or low responsiveness might allow the therapeutic effects of acupuncture to be better predicted.…”

Section: Introductionmentioning

confidence: 99%

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What intrinsic factors influence responsiveness to acupuncture in pain?: a review of pre-clinical studies that used responder analysis

Kim

Park

Kim

et al. 2017

BMC Complement Altern Med

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BackgroundNot many studies have investigated individual sensitivity to acupuncture. To explore the intrinsic factors related to individual responses to acupuncture, we reviewed published pre-clinical studies using responder analysis on pain.MethodsWe searched the PubMed and EMBASE databases to June 2015. We included pre-clinical reports describing responders and non-responders to anti-nociceptive and analgesic effects of acupuncture in animal study. We identified the potential intrinsic factors which might be related with the response to acupuncture.ResultsTotally, 216 potentially relevant articles were retrieved and 14 studies met our inclusion criteria. Rat (n = 1348) and rabbit (n = 56) were used, and only electroacupuncture (EA) was applied as an intervention. Results showed that high levels of cholecystokinin-8 and receptors were associated with poor responsiveness to EA. Endogenous opioids including β-endorphin and met-enkephalin, descending inhibitory norepinephrine and serotonin system, and hypothalamic 5′-AMP-activated protein kinase seemed to be associated with high-level responses. Spinal levels of neurotransmitters and pro-inflammatory cytokines were also differentially expressed depending on the EA sensitiveness. In the central nervous system, hypothalamus, periaqueductal grey, pituitary gland, and spinal cord were suggested to be involved in the EA responsiveness. Identified individual variations did not seem to be accidental, as the responsiveness to EA was replicated over time. However, methodological issues such as reproducibility, cut-off criteria, and clinical relevance need to be further elaborated.ConclusionOur study suggests that the identification of the biological factors differentiating responders from non-responders is necessary and it may aid in understanding how acupuncture modulates pain.Electronic supplementary materialThe online version of this article (doi:10.1186/s12906-017-1792-2) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

What intrinsic factors influence responsiveness to acupuncture in pain?: a review of pre-clinical studies that used responder analysis

Kim

Park

Kim

et al. 2017

BMC Complement Altern Med

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“…In many studies it has been observed that electroacupuncture application caused an increase in the levels of beta endorphin both in serum and in the central nervous system (Jin et al, 1996;Takeshige et al, 1992Takeshige et al, , 1993Fu, 2000;Petti et al, 1998) (Figure 1). It has been determined that electroacupuncture application with different current frequencies causes the secretion of different endojen opioids.…”

Section: Acupuncture Beta Endorphin and Lipolitic Activitymentioning

confidence: 93%

The Treatment of Obesity by Acupuncture

Cabýoglu

Ergene

Tan

2006

International Journal of Neuroscience

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The present study is an investigation of the results of the studies on the effects of acupuncture application therapy on obesity. It has been reported that acupuncture application in obesity treatment is effective in procuring weight loss. It can affect appetite, intestinal motility, and metabolism, as well as emotional factors such as stress. Increases in neural activity in the ventromedial nuclei of the hypothalamus, in tone in the smooth muscle of the stomach and in levels of enkephalin, beta endorphin, and serotonin in plasma and brain tissue have also been observed with the application of acupuncture. It has been observed that acupuncture application to obese people increases excitability of the satiety center in the ventromedial nuclei of the hypothalamus. Acupuncture stimulates the auricular branch of the vagal nerve and raises serotonin levels. Both of these activities have been shown to increase tone in the smooth muscle of the stomach, thus suppressing appetite. Among other things, serotonin enhances intestinal motility. It also controls stress and depression via endorphin and dopamine production. In addition to these effects, it is thought that the increase in plasma levels of beta endorphin after acupuncture application can contribute to the body weight loss in obese people by mobilizing the body energy depots through lipolithic effect.

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Scientific Basis of Acupuncture

Pomeranz

Berman

2003

Basics of Acupuncture

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Positive feedback action of pituitary β-Endorphin on acupuncture analgesia afferent pathway

Cited by 35 publications

References 14 publications

What intrinsic factors influence responsiveness to acupuncture in pain?: a review of pre-clinical studies that used responder analysis

What intrinsic factors influence responsiveness to acupuncture in pain?: a review of pre-clinical studies that used responder analysis

The Treatment of Obesity by Acupuncture

Scientific Basis of Acupuncture

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