2019
DOI: 10.3390/jcm8030385
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Positive Immuno-Modulation Following Radiofrequency Assisted Liver Resection in Hepatocellular Carcinoma

Abstract: Introduction: Hepatocellular carcinoma (HCC) often develops on a background of chronic inflammation and a complex immunosuppressive network with increased regulatory T cells, impaired CD8+ T cells and the secretion of immunosuppressive cytokines. Previous clinical studies have reported a superior disease-free survival (DFS) following a radiofrequency-based ablation or resection in HCC tumours compared to conventional liver resection techniques. The aim of this study was to investigate whether there is any corr… Show more

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Cited by 23 publications
(31 citation statements)
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“…Cell necrosis results in an uncontrolled release of cellular components into the extracellular space which initiates an inflammatory response. Initially, innate immune cells rapidly react and infiltrate into the tissue site, followed by activation of adaptive immune cells [ 10 , 11 ]. This process also triggers an antitumour response, since these tumour-specific antigens become accessible to whole immune system components ( Figure 1 ).…”
Section: Immunomodulation Mediated By Ablation Techniquesmentioning
confidence: 99%
See 2 more Smart Citations
“…Cell necrosis results in an uncontrolled release of cellular components into the extracellular space which initiates an inflammatory response. Initially, innate immune cells rapidly react and infiltrate into the tissue site, followed by activation of adaptive immune cells [ 10 , 11 ]. This process also triggers an antitumour response, since these tumour-specific antigens become accessible to whole immune system components ( Figure 1 ).…”
Section: Immunomodulation Mediated By Ablation Techniquesmentioning
confidence: 99%
“…The phenomenon, whereby a locally applied therapy triggers a distant antitumour response, is well known in radiation therapy as the abscopal effect [ 12 ]. For conventional surgical resections, there is no such phenomenon as there is direct tumour removal instead of local destruction [ 11 ].…”
Section: Immunomodulation Mediated By Ablation Techniquesmentioning
confidence: 99%
See 1 more Smart Citation
“…According to meta-analysis performed by Ding et al, increased density of tumour infiltrating lymphocytes (TILs) have been significantly associated with improved survival [78]. Additionally, studies have outlined positive immunomodulatory change following the application of RF in terms of Tregs, CD8+ T-cells, TGF-β, IFNγ, IL-10, IL-17, respectively [79][80][81][82].…”
Section: Hcc Tumour Microenvironment Immunomodulation Through Combinementioning
confidence: 99%
“…immunomodulatory change following the application of RF in terms of Tregs, CD8+ T-cells, TGF-β, IFNγ, IL-10, IL-17, respectively [79][80][81][82].…”
Section: Hcc Tumour Microenvironment Immunomodulation Through Combinementioning
confidence: 99%