Positive Impact of Prescribed Physical Activity on Symptoms of Schizophrenia: Randomized Clinical Trial

Ćurčić, Đorđe; Stojmenović, Tamara; Djukić-Dejanović, Slavica; Dikić, Nenad; Vesic-Vukasinovic, Milica; Radivojević, N.; Andjelkovic, Marija; Borovcanin, M.; Djokic, G.

doi:10.24869/psyd.2017.459

Cited by 38 publications

(57 citation statements)

References 31 publications

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“…As shown in Tables and , 38 studies met criteria for inclusion in the qualitative synthesis and all were published after 2005 .…”

Section: Resultsmentioning

confidence: 99%

“…Nineteen studies included subgroups classified as Stage 3 , of which four included a matched HC group and one included a general population reference sample . Seven studies included subgroups classified as Stage 4 , of which two included matched HC groups .…”

Section: Resultsmentioning

confidence: 99%

“…The latter was often higher in established cases than HC , and some studies targeted patients who were clinically obese (who are more likely to have impaired CRF . Furthermore, where CRF was reported separately according to sex (in the original study), there was a trend for female subgroups to show a smaller difference in mean CRF scores between cases and controls (than male cases vs. male controls) .…”

Section: Resultsmentioning

confidence: 99%

“…Twenty‐two studies reported CRF data as mean scores for VO 2 (max, peak, or predicted VO2 in ml/kg/min), and 10 of these studies included data for HC (Stage 1 = 1; Stages 1 and 2 = 1; Stage 2 = 2; Stage 3 = 5; Stage 4 = 2). Figure reports the sample sizes for each group in the 10 eligible studies, and the forest plot demonstrates the overall ES for CRF (with 95% CI) for all studies and then the ES for each clinical stage.…”

Section: Resultsmentioning

confidence: 99%

“…Nineteen studies included subgroups classified as Stage 3 (24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42), of which four included a matched HC group (30)(31)(32)40) and one included a general population reference sample (39). Seven studies included subgroups classified as Stage 4 (43)(44)(45)(46)(47)(48)(49), of which two included matched HC groups (45,46).…”

Section: Description Of Included Studies and Quality Assessmentmentioning

confidence: 99%

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Is there an association between cardiorespiratory fitness and stage of illness in psychotic disorders? A systematic review and meta‐analysis

Heggelund

Vancampfort

Tacchi

et al. 2019

Acta Psychiatr Scand

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Background Clinical staging models describe where an individual exists on a continuum from asymptomatic at‐risk states (Stage 0) through to established late‐stage disease (Stage 4). We applied this framework to systematically assess evidence for any associations between objectively assessed cardiorespiratory fitness (CRF) and stage of psychosis. Method Nine electronic databases were searched for relevant publications from inception until October 31, 2019. Pooled effect sizes (Hedges’ g and 95% confidence intervals (95% CI)) were estimated for differences in CRF for studies that reported mean oxygen uptake (max, peak, or predicted VO2 in ml/kg/min). Results Thirty‐eight studies were eligible. Findings indicated that suboptimal CRF can be present at Stages 0 and 1. Meta‐analyses of 22 studies demonstrated that CRF was significantly reduced in individuals classified between Stages 1 and 4 compared with matched or general population controls (g = −0.93; 95% CI −1.14, −0.71). Mean VO2 was decreased by 28% in Stage 4 compared with Stage 1 (34.1 vs. 24.66 ml/kg/min); the largest effect size for CRF reduction was reported between Stages 2 and 3 (g = −1.16; 95% CI −1.31, −1.03). Conclusions Although not identifying direct causal links between clinical stage and CRF, using this framework may enhance understanding of co‐associations between mental and physical health markers across the entire spectrum of psychosis. Limitations include lack of research on CRF in Stages 0 and 1 alongside problems determining stage in some studies. However, impaired CRF is reported in emerging psychosis, supporting calls that early intervention programmes should address both mental and physical wellbeing.

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“…As shown in Tables and , 38 studies met criteria for inclusion in the qualitative synthesis and all were published after 2005 .…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Description Of Included Studies and Quality Assessmentmentioning

confidence: 99%

See 3 more Smart Citations

Is there an association between cardiorespiratory fitness and stage of illness in psychotic disorders? A systematic review and meta‐analysis

Heggelund

Vancampfort

Tacchi

et al. 2019

Acta Psychiatr Scand

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Tackling Healthcare Disparities in Severe Mental Disorders: Integrating Physical Activity Therapies and Professionals into Mental Health with the Psychiactive Project

Álvaro,

Camilo,

Jesús

et al. 2024

The Landscape of Global Health Inequity

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Aerobic exercise in severe mental illness: requirements from the perspective of sports medicine

Falkai

Schmitt

Rosenbeiger

et al. 2021

Eur Arch Psychiatry Clin Neurosci

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Major depression, bipolar disorder, and schizophrenia are severe mental illnesses. Despite receiving psychopharmacological and psychosocial treatments, about half of patients develop a chronic course with residual cognitive and negative symptoms and have a high risk for cardiovascular disease and reduced life expectancy. Therefore, add-on innovative treatment approaches are needed to improve outcome. Aerobic exercise interventions have been shown to improve global functioning, cognition, and negative and depressive symptoms in these patients. The basic mechanism of these exercise-related changes has been reported to be improved brain plasticity, e.g., increased volume of disease-related brain regions such as the hippocampus. The optimal type, duration, and frequency of exercise have not yet been determined and need to be addressed in supervised physical exercise studies. Because of the low physical activity levels, lack of drive related to negative and depressive symptoms, and high prevalence of cardiovascular comorbidities in patients with severe mental illness, besides aiming to improve symptoms of mental illness, exercise interventions should also aim to increase cardiorespiratory fitness, which they should comprehensively assess by direct measurements of maximal oxygen uptake. Based on the recommendations for developing cardiorespiratory fitness by the American College of Sports Medicine, 150 min moderate-intensity training per week or vigorous-intensity exercise training for 75 min per week are appropriate. Most studies have had relatively short intervention periods, so future studies should focus on long-term adherence to exercise by implementing motivational strategies supported by telemedicine and by identifying and targeting typical barriers to exercise in this patient population.

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Positive Impact of Prescribed Physical Activity on Symptoms of Schizophrenia: Randomized Clinical Trial

Cited by 38 publications

References 31 publications

Is there an association between cardiorespiratory fitness and stage of illness in psychotic disorders? A systematic review and meta‐analysis

Is there an association between cardiorespiratory fitness and stage of illness in psychotic disorders? A systematic review and meta‐analysis

Tackling Healthcare Disparities in Severe Mental Disorders: Integrating Physical Activity Therapies and Professionals into Mental Health with the Psychiactive Project

Aerobic exercise in severe mental illness: requirements from the perspective of sports medicine

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