Positive modulation of α5GABAA receptors leads to dichotomous effects in rats on memory pattern and GABRA5 expression in prefrontal cortex and hippocampus

Effects of α5 GABAA receptor modulation on social interaction, memory, and neuroinflammation in a mouse model of Alzheimer's disease

“…As likewise expected, 38 social memory was preserved in transgenic and non‐transgenic male controls, while MP‐III‐022 induced social memory impairment in males of both genotypes. The latter results are consistent with findings of impaired social discrimination elicited by MP‐III‐022 treatment in Wistar rats 9 . PWZ‐029 did not have any influence, which is in line with research by Paine and co‐workers 16 …”

“…Not only that MP‐III‐022 failed to demonstrate improvement in object memory in transgenic female animals, but also suppressed this type of memory in non‐transgenic females. These data are aligned with results obtained in rats, with MP‐III‐022 suppressing long‐term object memory when dosed at 10 mg/kg 24 h before the test 9 …”

“…6 Apparently contradictory, in another mouse model of AD it was shown that both, activation and inhibition of GABA A receptors (by muscimol and bicuculline, respectively), may improve spatial recognition memory. 7 In various tests other than those modeling AD, both a positive allosteric modulator (PAM) [8][9][10] and NAM 11,12 appeared to have a potential to restore object and spatial memory, with PAM being favored in the context of aging. 8 Activity of mouse parvalbumin-positive (PV) interneurons in medial prefrontal cortex (PFC) elicited by low gamma frequency stimulation, as well as muscimol treatment in the dorsomedial PFC, resulted in a prosocial effect leading to increased social interaction.…”

“… 6 Apparently contradictory, in another mouse model of AD it was shown that both, activation and inhibition of GABA A receptors (by muscimol and bicuculline, respectively), may improve spatial recognition memory. 7 In various tests other than those modeling AD, both a positive allosteric modulator (PAM) 8 , 9 , 10 and NAM 11 , 12 appeared to have a potential to restore object and spatial memory, with PAM being favored in the context of aging. 8 …”

Postweaning positive modulation of α5GABAA receptors improves autism‐like features in prenatal valproate rat model in a sex‐specific manner

“…The animals were decapitated, their hippocampi were isolated and kept at −80°C until the isolation of RNA. RNA was isolated and real‐time PCR performed as previously described (Santrač et al, 2022) with primers listed in Suppl. Table 1.…”