Positive/negative surface charge of chitosan based nanogels and its potential influence on oral insulin delivery

Wang, Juan; Xu, Mengxue; Cheng, Xiaojie; Kong, Ming; Liu, Ya; Feng, Chao; Chen, Xiguang

doi:10.1016/j.carbpol.2015.09.103

Cited by 86 publications

(36 citation statements)

References 22 publications

(6 reference statements)

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“…Negatively charged nanogels showed superior adhesion and permeation skills in the rat jejunum in comparison with positively charged ones. In accordance with that, according to an in vivo experiment in diabetic rats, the glucose-reducing ability of negatively charged nanogels was better as well (48).…”

Section: Nanoemulsionssupporting

confidence: 80%

Nanocarriers: Novel Approaches to Oral Delivery of Insulin

Özer¹,

Kerımoğlu²,

Uğurlu³

2017

Clin Exp Health Sci

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Section: Nanoemulsionssupporting

confidence: 80%

Nanocarriers: Novel Approaches to Oral Delivery of Insulin

Özer¹,

Kerımoğlu²,

Uğurlu³

2017

Clin Exp Health Sci

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“…Gels have many adjustable properties, including their flexibility and deformability, dispersibility in biological fluids, controlled stability, biodegradability, and chemical function [159,160]. Compared with nanoparticles, gels have better mucoadhesivity and permeability and can transport small molecules, all of which gives them great potential in biomedical fields [161].…”

Section: Delivery Carriermentioning

confidence: 99%

Chitosan Derivatives and Their Application in Biomedicine

Wang

Meng

et al. 2020

IJMS

651

326

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Chitosan is a product of the deacetylation of chitin, which is widely found in nature. Chitosan is insoluble in water and most organic solvents, which seriously limits both its application scope and applicable fields. However, chitosan contains active functional groups that are liable to chemical reactions; thus, chitosan derivatives can be obtained through the chemical modification of chitosan. The modification of chitosan has been an important aspect of chitosan research, showing a better solubility, pH-sensitive targeting, an increased number of delivery systems, etc. This review summarizes the modification of chitosan by acylation, carboxylation, alkylation, and quaternization in order to improve the water solubility, pH sensitivity, and the targeting of chitosan derivatives. The applications of chitosan derivatives in the antibacterial, sustained slowly release, targeting, and delivery system fields are also described. Chitosan derivatives will have a large impact and show potential in biomedicine for the development of drugs in future.

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“…[7][8][9][10][11][12] They can offer drug protection and facilitate drug absorption through the intestinal mucosa due to the increasing the time and amount of interaction with the mucus layer of the intestine. [8] Nanocarriers of natural and synthetic biodegradable polymers [6,[13][14][15][16][17][18][19] and lipids [20] have been used to date for oral delivery of insulin. For example, Lowman et al [21] were prepared A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT 4 insulin-loaded poly((methacrylic acid)-grafted-poly(ethylene glycol)) hydrogel microspheres that greatly increased insulin transport.…”

Section: Introductionmentioning

confidence: 99%