Positive Phadiatop Infant (Phinf) can predict allergic disease during childhood

Glaumann, Susanne; Lilja, G.; Nopp, Anna; Nilsson, Caroline

doi:10.1111/pai.13266

Cited by 2 publications

(2 citation statements)

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“…A mix of allergen extracts (eg, Phadiatop, Thermo Fisher) can be used for screening of allergic sensitization with the advantage of including various allergens in one test but at the expense of lower sensitivity compared with the single tests. 9 However, like SPT, sIgE levels indicate sensitization. Following allergen exposure through ingestion, cutaneous, parenteral or inhalation, the allergen is taken up by antigen-presenting cells and through interaction with T cells, cytokine and chemokines are secreted and B-cell lymphocytes become committed to producing sIgE antibodies to that allergen.…”

Section: Specific Ige Testingmentioning

confidence: 99%

“…Similarly to SPT, serum sIgE levels have been used to support the diagnosis of food allergy. A mix of allergen extracts (eg, Phadiatop, Thermo Fisher) can be used for screening of allergic sensitization with the advantage of including various allergens in one test but at the expense of lower sensitivity compared with the single tests 9 . However, like SPT, sIgE levels indicate sensitization.…”

Section: Diagnosis Of Ige‐mediated Food Allergymentioning

confidence: 99%

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Biomarkers of diagnosis and resolution of food allergy

Foong

2020

Pediatric Allergy Immunology

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Food allergy is increasing in prevalence, affecting up to 10% of children in developed countries. Food allergy can significantly affect the quality of life and well‐being of patients and their families; therefore, an accurate diagnosis is of extreme importance. Some food allergies can spontaneously resolve in 50%‐60% of cow’s milk and egg‐allergic, 20% of peanut‐allergic and 9% of tree nut‐allergic children by school age. For that reason, food‐allergic status should be monitored over time to determine when to reintroduce the food back into the child’s diet. The gold‐standard to confirm the diagnosis and the resolution of food allergy is an oral food challenge; however, this involves the risk of causing an acute‐allergic reaction and requires clinical experience and resources to treat allergic reactions of any degree of severity. In the clinical setting, biomarkers have been used and validated to enable an accurate diagnosis when combined with the clinical history, deferring the oral food challenge, whenever possible. In this review, we cover the tools available to support the diagnosis of food allergies and to predict food allergy resolution over time. We review the latest evidence on different testing modalities and how effective they are in guiding clinical decision making in practice. We also evaluate predictive test cut‐offs for the more common food allergens to try and provide guidance on when challenges might be most successful in determining oral tolerance in children.

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Section: Specific Ige Testingmentioning

confidence: 99%

Section: Diagnosis Of Ige‐mediated Food Allergymentioning

confidence: 99%