Positive predictive value for diffusion-weighted magnetic resonance imaging in pediatric cholesteatoma: A retrospective study

Hervochon, Rémi; Elmaleh‐Bergès, Monique; François, M.; Marhic, Alix; Bahakim, Abdullah; Teissier, Natacha; Abbeele, T. Van Den

doi:10.1016/j.ijporl.2020.110416

Cited by 4 publications

(4 citation statements)

References 12 publications

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“…A previous study of the paediatric population revealed a trend towards smaller areas of avidity where there were false positives. 16 In our study, small areas of avidity on diffusion-weighted MRI were also seen in our false positive group (Figure 2). One study, specifically focusing on false positives in the adult population, reported that in three of the four false positive cases, areas of high avidity disappeared on subsequent imaging.…”

Section: Discussionsupporting

confidence: 62%

Diffusion-weighted magnetic resonance imaging for diagnosis of post-operative paediatric cholesteatoma

et al. 2022

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Objectives High rates of recidivism are reported after paediatric cholesteatoma surgery. Our practice has adapted to include non-echoplanar diffusion-weighted magnetic resonance imaging for the diagnosis of residual or recurrent cholesteatoma. This audit aimed to evaluate the performance of non-echoplanar diffusion-weighted magnetic resonance imaging in our paediatric population. Methods A retrospective review was conducted of non-echoplanar diffusion-weighted magnetic resonance imaging scans performed to detect residual disease or recurrence after surgery for cholesteatoma in children from 1 January 2012 to 30 November 2017 in our centre. Follow-up diffusion-weighted magnetic resonance imaging scans were reviewed to 16 August 2019. Results Thirty-four diffusion-weighted magnetic resonance imaging scans were included. The sensitivity and specificity values of diffusion-weighted magnetic resonance imaging for detecting post-operative cholesteatoma were 81 per cent and 72 per cent, respectively. Positive predictive and negative predictive values were 72 per cent and 81 per cent, respectively. Conclusion Use of diffusion-weighted magnetic resonance imaging is recommended as a replacement for routine second-look surgical procedures in the paediatric population. However, we would caution that patients require close follow up after negative diffusion-weighted magnetic resonance imaging findings.

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Section: Discussionsupporting

confidence: 62%

Diffusion-weighted magnetic resonance imaging for diagnosis of post-operative paediatric cholesteatoma

et al. 2022

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“…A residual cholesteatoma was diagnosed in 35% (n = 112) of MRI. The mean size of the residual cholesteatoma was 5 ± 2.4 mm [2][3][4][5][6][7][8][9][10][11][12][13][14] (n = 58).…”

Section: Population: Children and Mrimentioning

confidence: 99%

“…In children, however, its performance seems to be poorer and has only been described in small cohorts. The largest study so far included 55 children with a sensitivity of 76% and specificity of 90% 12‐14 . Also, the minimal size of detection of residual disease is an issue, usually set at 3 mm in diameter and requiring repeated MRI 1,15,16 .…”

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Performance of Non‐EPI DW MRI for Pediatric Cholesteatoma Follow‐Up

Daoudi

Lévy

Baudouin

et al. 2023

Otolaryngol.--head neck surg.

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ObjectiveTo evaluate the accuracy, sensitivity, and specificity of nonecho planar (non‐EPI) diffusion‐weighted (DW) magnetic resonance imaging (MRI) to detect residual cholesteatoma in children.Study DesignRetrospective study.SettingTertiary comprehensive hospital.MethodsChildren operated on for a first‐stage cholesteatoma procedure from 2010 to 2019 were included. MRIs were performed with non‐EPI DW sequences. Initial reports were collected, indicating the presence or absence of hyperintensity suggestive of cholesteatoma. Three hundred twenty‐three MRIs were correlated with the subsequent surgery (66%) or year‐later MRI (21%), or were considered accurate if performed 5 years or more after the last surgery (13%). The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of each imaging procedure for the detection of cholesteatoma were calculated.ResultsTwo hundred twenty‐four children with mean age of 9 ± 4 years old presented with cholesteatoma. MRIs were performed 27 ± 24 months after surgery. Residual cholesteatoma was diagnosed in 35%. The sensitivity, specificity, PPV, and NPV of MRI were 62%, 86%, 74%, and 78%, respectively. Accuracy, sensitivity, and specificity increased significantly over time (multivariate analysis). The mean delay after last surgery was of 30 ± 2.0 months for accurate MRI (true positive or negative) versus 17 ± 2.0 months for nonaccurate (false positive or negative) MRIs (p < .001).ConclusionHowever, long the delay after the last surgery, the sensitivity of non‐EPI diffusion sequence MRI in children has limitations for the detection of residual cholesteatoma. Surveillance for residual cholesteatoma should incorporate findings at primary surgery, surgeon experience, a low threshold for second‐look procedures, and routine imaging.

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PROPELLER diffusion weighted imaging for diagnosis of cholesteatoma in comparison with surgical and histopathological results: emphasis on false positivity and false negativity

Semiz-Oysu

Oysu

Kulalı

et al. 2023

Eur Arch Otorhinolaryngol

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Positive predictive value for diffusion-weighted magnetic resonance imaging in pediatric cholesteatoma: A retrospective study

Cited by 4 publications

References 12 publications

Diffusion-weighted magnetic resonance imaging for diagnosis of post-operative paediatric cholesteatoma

Diffusion-weighted magnetic resonance imaging for diagnosis of post-operative paediatric cholesteatoma

Performance of Non‐EPI DW MRI for Pediatric Cholesteatoma Follow‐Up

PROPELLER diffusion weighted imaging for diagnosis of cholesteatoma in comparison with surgical and histopathological results: emphasis on false positivity and false negativity

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