Positive predictive value of different methods for identifying Parkinson's disease cases in an epidemiological study

Abbas, Masoom M.; Koh, Woon-Puay; Tan, Eng‐King; Tan, Louis

doi:10.1016/j.parkreldis.2018.04.013

Cited by 3 publications

(2 citation statements)

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“…First, Yang and colleagues used ICD codes in registry data, with a positive predictive value of 70.8% and a sensitivity of 72.7%. On the other hand, all incident PD cases in the SCHS were confirmed by manual review of notes, with a positive predictive value of up to 95.4% 47 . As such, the Swedish study may have included a significant number of patients who have other forms of parkinsonism instead of PD.…”

Section: Discussionmentioning

confidence: 99%

Dietary Antioxidants and Risk of Parkinson's Disease in the Singapore Chinese Health Study

Ying

Khan

et al. 2020

Movement Disorders

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A BS TRACT: Background: Despite experimental evidence implicating oxidative stress in the pathogenesis of PD, epidemiological studies have provided inconsistent associations between dietary antioxidants and risk of developing PD. Furthermore, no study has been done in any Asian population. Objectives: We examined the associations for intake levels of dietary carotenoids (α-carotene, β-carotene, lycopene, β-cryptoxanthin, and lutein) and vitamins (vitamin A, C and E) and the risk of developing PD. Methods: We used data from the Singapore Chinese Health Study, a population-based prospective cohort of 63,257 men and women aged 45 to 74 years during enrollment in 1993-1998. Antioxidant intake was derived from a validated semiquantitative food frequency questionnaire. Incident cases were identified through followup interviews, hospital records, or PD registries through 31 July 2018. Hazard ratios and corresponding 95% confidence intervals were derived from multivariable Cox proportional hazard regression models with adjustment for other lifestyle and dietary factors. Results: During an average 19.4 years of follow-up, 544 incident PD cases were identified. No association was found for dietary carotenoids, individually or summed. Hazard ratio comparing highest to lowest quartile for total carotenoids was 0.98 (95% confidence interval: 0.76-1.28; P trend = 0.83). There were also no clear dose-dependent associations of dietary vitamins A, C, and E with risk of developing PD (all P trend ≥ 0.10). Sensitive analyses with lag time and excluding supplement use did not materially alter results. Conclusions: Intake of dietary antioxidants, such as carotenoids and vitamins, was not associated with the risk of developing PD in Singaporean Chinese.

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Section: Discussionmentioning

confidence: 99%

Dietary Antioxidants and Risk of Parkinson's Disease in the Singapore Chinese Health Study

Ying

Khan

et al. 2020

Movement Disorders

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“…The diagnosis of Parkinson's disease (PD) in clinical practice lacks objective verification and mainly based on motor symptoms, which have not yielded great accuracy [1,2]. Significant motor symptoms generally emerge in the advanced stage resulted in poor prognosis and poor quality of life.…”

Section: Introductionmentioning

confidence: 99%

"Susceptibility MRI in Brain Nuclei Improves Early Diagnosis of Parkinson’s Disease Using Linear Discriminant Analysis Method"

Feng Xu

2024

BJSTR

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The study aimed to explore a new imaging biomarker based on quantitative susceptibility mapping (QSM) using linear discriminant analysis (LDA) method for improving early diagnosis of Parkinson's disease. 34 PD patients and 15 controls were enrolled, and the PD patients were divided into two groups (early-stage and advanced-stage groups) based on the Hoehn-Yahr assessment. Magnetic susceptibilities in six brain structures, including the caudate nucleus (CN), globus pallidus (GP), thalamus (THA), putamen (PUT), substantia nigra (SN) and red nucleus (RN), were measured. Mean susceptibilities were measured and compared between the PD patients and controls. Linear discriminant analysis (LDA) of machine learning (ML) was applied to integrate the magnetic susceptibilities in all nuclei as a new biomarker (LDA biomarker). ROC curves were calculated to evaluate the effectiveness of various indicators. Susceptibilities in all nuclei showed an increase in heterogeneity in the PD patients. Compared to the controls, the PD patients had significantly increased magnetic susceptibilities in the PUT and THA, and there were significant differences in the THA between the controls and early-PD patients. The LDA biomarker had the highest AUC (0.784) for classifying PD patients and making an early PD diagnosis (0.777). LDA biomarker derived from ML based on QSM is a promising tool for early diagnosis and advanced assessment of PD.

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Efficacy of 11C-2β-carbomethoxy-3β-(4-fluorophenyl) tropane positron emission tomography combined with 18F-fluorodeoxyglucose positron emission tomography in the diagnosis of early Parkinson disease

Jiang¹,

Wang²,

Li³

et al. 2020

Medicine

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Background: Parkinson's disease (PD) has a high incidence in the elderly, and the late stage seriously affects the daily life of the patients. Most of the initial symptoms of PD are not obvious or atypical, which brings difficulties to the early diagnosis. Replacement therapy and neuroprotection after early diagnosis can significantly improve the prognosis and quality of life of patients. More and more evidence shows that 11 C-2β-carbomethoxy-3β-(4-fluorophenyl) tropane positron emission tomography ( 11 C-CFT PET) combined with 18 F-fluorodeoxyglucose positron emission tomography ( 18 F-FDG PET) can effectively improve the accuracy of early diagnosis. However, there is no consistent conclusion at present. The purpose of this study is to evaluate the efficacy of 11 C-CFT PET combined with 18 F-FDG PET in the diagnosis of early PD. Methods: We will search 7 electronic databases (PubMed, EMBASE, Web of Science, Cochrane library, PsycINFO, AMED, Scopus), ongoing trials and grey literature to collect related randomized controlled trials and will use Review Manager Software 5.2 and STATA Software 16.0 for analysis and synthesis. Results: We will integrate the existing randomized controlled trials to evaluate the value of 11 C-CFT PET combined with 18 F-FDG PET in the diagnosis of early PD. Conclusion: Our study may prove that 11 C-CFT PET combined with 18 F-FDG PET can effectively diagnose early PD. Registration number: International Prospective Register of Systematic Reviews (PROSPERO): CRD42020203442.

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Positive predictive value of different methods for identifying Parkinson's disease cases in an epidemiological study

Cited by 3 publications

References 4 publications

Dietary Antioxidants and Risk of Parkinson's Disease in the Singapore Chinese Health Study

Dietary Antioxidants and Risk of Parkinson's Disease in the Singapore Chinese Health Study

"Susceptibility MRI in Brain Nuclei Improves Early Diagnosis of Parkinson’s Disease Using Linear Discriminant Analysis Method"

Efficacy of 11C-2β-carbomethoxy-3β-(4-fluorophenyl) tropane positron emission tomography combined with 18F-fluorodeoxyglucose positron emission tomography in the diagnosis of early Parkinson disease

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