Positive ratio of specific antibodies to F protein in serum samples from chronic HCV-infected patients using an enzyme-linked immunosorbent assay

Liu, Jie; Yu, Wenhua; Liu, Shuye

doi:10.1097/meg.0b013e328360fa2e

Cited by 2 publications

(6 citation statements)

References 29 publications

(48 reference statements)

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“…Humoral immune system can recognize F protein which leads to production of antibodies against F protein 10,13,24 . F protein have three main antigenic domains including the residue 1 to 28, 48 to 75, and 85 to 98.…”

Section: F Protein and Humoral Immune Responsesmentioning

confidence: 99%

“…These antigenic domains might be responsible for activation of immunologic system against F protein. 25 Interestingly anti-F protein antibody detection ratio is higher in chronic patients, 10,13 which suggests an association between F protein expression and pathogenesis of the disease leading to chronic…”

Section: F Protein Propertiesmentioning

confidence: 99%

“…Although the actual function of this protein is not known yet, it's shown that F protein can induce humoral immune responses. F protein can induce specific antibodies in most of the chronic HCV infected patients 10 . F protein also modulates cellular immune responses, 11 where it causes persistent infection.…”

Section: Introductionmentioning

confidence: 99%

“…F protein can induce specific antibodies in most of the chronic HCV infected patients. 10 F protein also modulates cellular immune responses, 11 where it causes persistent infection. Moreover, innate immune responses are also affected by the F protein expression.…”

mentioning

confidence: 99%

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Hepatitis C virus alternative reading frame protein (ARFP): Production, features, and pathogenesis

Mohamadi

Azarbayjani

Mozhgani

et al. 2020

Journal of Medical Virology

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Earlier observation suggests that hepatitis C virus (HCV) is a single‐stranded RNA virus which encodes at least 10 viral proteins. F protein is a novel protein which has been discovered recently. These studies suggest three mechanisms for the production of this protein concerning ribosomal frameshift at codon 10, initial translation at codons 26 and 85 or 87. In this study, the association between protein F and chronicity of hepatocellular carcinoma (HCC) has been reviewed. Evidence suggests that humoral immune system can recognize this protein and produce antibodies against it. By detecting antibodies in infected people, investigators found that F protein might have a role in HCV infection causing chronic cirrhosis and HCC as higher prevalence was found in patients with mentioned complications. The increment of CD4+, CD25+, and FoxP3+ T cells, along with CD8+ T cells with low expression of granzyme B, also leads to weaker responses of the immune system which helps the infection to become chronic. Moreover, it contributes to the survival of the virus in the body through affecting the production of interferon. F protein also might play roles in the disease development, resulting in HCC. The existence of F protein affects cellular pathways through upregulating p53, c‐myc, cyclin D1, and phosphorylating Rb. This review will summarize these effects on immune system and related mechanisms in cellular pathways.

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Section: F Protein and Humoral Immune Responsesmentioning

confidence: 99%

Section: F Protein Propertiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Hepatitis C virus alternative reading frame protein (ARFP): Production, features, and pathogenesis

Mohamadi

Azarbayjani

Mozhgani

et al. 2020

Journal of Medical Virology

View full text Add to dashboard Cite

show abstract

“…In addition, there were reviews of interleukin-28B polymorphism as a predictor of SVR in patients with chronic HCV treated with triple therapy,33 treatment of HCV among people who inject drugs,34 and the positive ratio of specific antibodies to F protein in serum samples from chronic HCV using an enzyme-linked immunosorbent assay 35. Reviews of research into psychological, lifestyle, and social predictors of HCV treatment response36 have been published in Liver International, and reviews about patient adherence to antiviral treatment37 and the effects of education interventions38 have also been published.…”

Section: Hcvmentioning

confidence: 99%

Overview and recent trends of systematic reviews and meta-analyses in hepatology

Kim

Baik

2014

Clin Mol Hepatol

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A systematic review (SR) is a research methodology that involves a comprehensive search for and analysis of relevant studies on a specific topic. A strict and objective research process is conducted that comprises a systematic and comprehensive literature search in accordance with predetermined inclusion/exclusion criteria, and an assessment of the risk of bias of the selected literature. SRs require a multidisciplinary approach that necessitates cooperation with clinical experts, methodologists, other experts, and statisticians. A meta-analysis (MA) is a statistical method of quantitatively synthesizing data, where possible, from the primary literature selected for the SR. Review articles differ from SRs in that they lack a systematic methodology such as a literature search, selection of studies according to strict criteria, assessment of risk bias, and synthesis of the study results. The importance of evidence-based medicine (EBM) in the decision-making for public policy has recently been increasing thanks to the realization that it should be based on scientific research data. SRs and MAs are essential for EBM strategy and evidence-based clinical practice guidelines. This review addresses the current trends in SRs and MAs in the field of hepatology via a search of recently published articles in the Cochrane Library and Ovid-MEDLINE.

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Positive ratio of specific antibodies to F protein in serum samples from chronic HCV-infected patients using an enzyme-linked immunosorbent assay

Cited by 2 publications

References 29 publications

Hepatitis C virus alternative reading frame protein (ARFP): Production, features, and pathogenesis

Hepatitis C virus alternative reading frame protein (ARFP): Production, features, and pathogenesis

Overview and recent trends of systematic reviews and meta-analyses in hepatology

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