Positive regulatory loop of platelet-derived growth factor DD-induced STAT3 activation is associated with poor prognosis in advanced urothelial carcinoma

Ando, Kiyohiro; Kurashina, Ryo; Motoi, Noriko; Iizuka, Toshihiko; Inoue, Masaharu; Maruyama, Riko; Mitani, Kouki; Takenobu, Hisanori; Haruta, Masayuki; Onuki, Ritsuko; Matsuoka, Yoh; Kageyama, Yukio

doi:10.1016/j.bbrc.2023.07.054

Cited by 2 publications

(2 citation statements)

References 18 publications

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Section: Discussionmentioning

confidence: 99%

Predicting bladder cancer survival with high accuracy: insights from MAPK pathway-related genes

Cheng,

Zhou,

et al. 2024

Sci Rep

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The mitogen-activated protein kinase (MAPK) pathway plays a critical role in tumor development and immunotherapy. Nevertheless, additional research is necessary to comprehend the relationship between the MAPK pathway and the prognosis of bladder cancer (BLCA), as well as its influence on the tumor immune microenvironment. To create prognostic models, we screened ten genes associated with the MAPK pathway using COX and least absolute shrinkage and selection operator (LASSO) regression analysis. These models were validated in the Genomic Data Commons (GEO) cohort and further examined for immune infiltration, somatic mutation, and drug sensitivity characteristics. Finally, the findings were validated using The Human Protein Atlas (HPA) database and through Quantitative Real-time PCR (qRT-PCR). Patients were classified into high-risk and low-risk groups based on the prognosis-related genes of the MAPK pathway. The high-risk group had poorer overall survival than the low-risk group and showed increased immune infiltration compared to the low-risk group. Additionally, the nomograms built using the risk scores and clinical factors exhibited high accuracy in predicting the survival of BLCA patients. The prognostic profiling of MAPK pathway-associated genes represents a potent clinical prediction tool, serving as the foundation for precise clinical treatment of BLCA.

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Section: Discussionmentioning

confidence: 99%

Predicting bladder cancer survival with high accuracy: insights from MAPK pathway-related genes

Cheng,

Zhou,

et al. 2024

Sci Rep

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“…MAP3K8 is an oncogene encoding a member of the serine/threonine protein kinase family, and studies have shown that high levels of MAP3K8 phosphorylation are associated with progression and poor prognosis in patients with bladder cancer 43 . Studies have indicated that PDGFD, a part of the platelet-derived growth factor family, is linked to gemcitabine resistance in BLCA patients and unfavorable prognosis in advanced uroepithelial carcinoma and pancreatic ductal adenocarcinoma (PDAC) 44,45 .PDGFRA, a receptor for tyrosine kinase, is frequently mutated in gastrointestinal mesenchymal stromal tumors (GIST) and serves as a target for anticancer medications like avastinib 46,47 . JUN has been implicated in APF-mediated growth inhibition of bladder tumor cells and is a potential target of APF in patients with invasive bladder cancer 48 , and overexpression of JUN protein is also closely associated with the invasive growth of BLCA 49 .DUSP2 belongs to the nuclear DUSP family, speci cally type I, and it inhibits the activation of MAPK while having a crucial function in immune processes, in ammatory responses, and the advancement of cancer.…”

Section: Discussionmentioning

confidence: 99%

Predicting Bladder Cancer Survival with High Accuracy: Insights from MAPK Pathway-related Genes

Cheng,

Li,

Zhou

et al. 2024

Preprint

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The mitogen-activated protein kinase (MAPK) pathway plays a critical role in tumor development and immunotherapy. Nevertheless, additional research is necessary to comprehend the relationship between the MAPK pathway and the prognosis of bladder cancer (BLCA), as well as its influence on the tumor immune microenvironment.To create prognostic models, we screened ten genes associated with the MAPK pathway using COX and least absolute shrinkage and selection operator (LASSO) regression analysis. These models were validated in the Genomic Data Commons (GEO) cohort and further examined for immune infiltration, somatic mutation, and drug sensitivity characteristics. Finally, the findings were validated using The Human Protein Atlas (HPA) database and through Quantitative Real-time PCR (qRT-PCR).Patients were classified into high-risk and low-risk groups based on the prognosis-related genes of the MAPK pathway. The high-risk group had poorer overall survival than the low-risk group and showed increased immune infiltration compared to the low-risk group. Additionally, the nomograms built using the risk scores and clinical factors exhibited high accuracy in predicting the survival of BLCA patients.The prognostic profiling of MAPK pathway-associated genes represents a potent clinical prediction tool, serving as the foundation for precise clinical treatment of bladder cancer.

show abstract

Positive regulatory loop of platelet-derived growth factor DD-induced STAT3 activation is associated with poor prognosis in advanced urothelial carcinoma

Cited by 2 publications

References 18 publications

Predicting bladder cancer survival with high accuracy: insights from MAPK pathway-related genes

Predicting bladder cancer survival with high accuracy: insights from MAPK pathway-related genes

Predicting Bladder Cancer Survival with High Accuracy: Insights from MAPK Pathway-related Genes

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