Positive remodeling is associated with more plaque vulnerability and higher frequency of plaque prolapse accompanied with post-procedural cardiac enzyme elevation compared with intermediate/negative remodeling in patients with acute myocardial infarction

Hong, Young Joon; Jeong, Myung Ho; Choi, Yun Ha; Ko, Jum Suk; Lee, Min Goo; Kang, Won Yu; Lee, Shin Eun; Kim, Soo Hyun; Park, Keun Ho; Sim, Doo Sun; Yoon, Nam Sik; Youn, Heejung; Kim, Kye Hun; Park, Hyung Wook; Kim, Ju Han; Cho, Jeong Gwan; Park, Jong Chun; Kang, Jung Chaee

doi:10.1016/j.jjcc.2008.12.006

Cited by 15 publications

(8 citation statements)

References 59 publications

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“…However, compared with negative remodeling, culprit lesion positive remodeling in ACS was associated with a higher rate of adverse cardiac events. Acute myocardial infarction (AMI) patients with culprit lesion positive remodeling had more plaque vulnerability and higher frequency of plaque prolapse accompanied by post-procedural cardiac enzyme elevation than patients with negative remodeling [ 53 ]. During the long term follow-up, both target lesion revascularization (TLR) and non-TLR rates were significantly higher in ACS patients with positive remodeling than in those with negative remodeling [ 54 ].…”

Section: Discussionmentioning

confidence: 99%

Increased glycated albumin and decreased esRAGE levels in serum are related to negative coronary artery remodeling in patients with type 2 diabetes: an Intravascular ultrasound study

Zhang

Lü

et al. 2018

Cardiovasc Diabetol

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BackgroundNegative coronary artery remodeling is frequent in patients with diabetes, but its mechanism remains unclear. We here evaluated the association of serum levels of glycated albumin (GA) and endogenous secretory receptor for advanced glycation end products (esRAGE) with coronary artery remodeling in type 2 diabetic patients.MethodsSerum levels of GA and esRAGE were measured and intravascular ultrasound was performed in 136 consecutive diabetic patients with 143 coronary intermediate lesions. The remodeling index (RI) was calculated as the ratio between external elastic membrane (EEM) area at the lesion site and EEM area at the reference segment. Negative remodeling (NR) was defined as an RI < 0.95 and intermediate or positive remodeling as an RI ≥ 0.95.ResultsMean plaque burden at the lesion site was 70.96 ± 9.98%, and RI was 0.96 ± 0.18. Negative coronary arterial remodeling existed in 81 (56.6%) lesions. RI correlated closely with serum esRAGE level (r = 0.236, P = 0.005) and was inversely related to serum GA level (r = − 0.240, P = 0.004) and plasma low-density lipoprotein cholesterol (LDL-C) (r = − 0.206, P = 0.014) and total cholesterol levels (r = − 0.183, P = 0.028). Generalized estimating equations logistic regression analysis identified esRAGE (OR 0.037; 95% CI 0.012–0.564, P = 0.021), GA (OR 1.093; 95% CI 1.013–1.179, P = 0.018) and LDL-C (OR 1.479; 95% CI 1.072–2.835, P = 0.023) as independent predictors for negative remodeling.ConclusionsIn diabetic patients, negative coronary artery remodeling is associated with increased GA and decreased esRAGE levels in serum.

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Section: Discussionmentioning

confidence: 99%

Increased glycated albumin and decreased esRAGE levels in serum are related to negative coronary artery remodeling in patients with type 2 diabetes: an Intravascular ultrasound study

Zhang

Lü

et al. 2018

Cardiovasc Diabetol

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“…iMAP-IVUS not only allows online delineation of tissue components for each category, but also provides realtime 40 MHz high-resolution gray-scale images, which are also fundamentally important. Most previous intra-coronary tissue classification studies employed VH-IVUS, in which gray-scale resolution is only 20 MHz [6,[20][21][22][23]. 2D analysis has the same limitation.…”

Section: Discussionmentioning

confidence: 99%

Visualization of coronary plaque in type 2 diabetes mellitus patients using a new 40MHz intravascular ultrasound imaging system

Araki

Nakamura

Utsunomiya

et al. 2012

Journal of Cardiology

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“…Endo et al 20) reported that ultrasound attenuation with a longitudinal length of ≥5 mm and plaque rupture correlated with no-reflow phenomenon in patients with STEMI. Our previous study 37) showed that positive remodeling, plaque rupture, IVUS-detected thrombus, and tissue prolapse were independently associated with post-stenting cardiac-specific troponin I elevation. In another previous study, 38) we demonstrated that tissue prolapse, high-sensitivity CRP, and culprit lesion multiple plaque ruptures were associated with post-PCI no-reflow in AMI patients with plaque rupture.…”

Section: Post-percutaneous Coronary Intervention Intravascular Ultrasmentioning

confidence: 93%

Roles of Intravascular Ultrasound in Patients with Acute Myocardial Infarction

2015

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Rupture of a vulnerable plaque and subsequent thrombus formation are important mechanisms leading to the development of an acute myocardial infarction (AMI). Typical intravascular ultrasound (IVUS) features of AMI include plaque rupture, thrombus, positive remodeling, attenuated plaque, spotty calcification, and thin-cap fibroatheroma. No-reflow phenomenon was attributable to the embolization of thrombus and plaque debris that results from mechanical fragmentation of the vulnerable plaque by percutaneous coronary intervention (PCI). Several grayscale IVUS features including plaque rupture, thrombus, positive remodeling, greater plaque burden, decreased post-PCI plaque volume, and tissue prolapse, and virtual histology-IVUS features such as large necrotic corecontaining lesion and thin-cap fibroatheroma were the independent predictors of no-reflow phenomenon in AMI patients. Non-culprit lesions associated with recurrent events were more likely than those not associated with recurrent events to be characterized by a plaque burden of ≥70%, a minimal luminal area of ≤4.0 mm2, or to be classified as thin-cap fibroatheromas.

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Positive remodeling is associated with more plaque vulnerability and higher frequency of plaque prolapse accompanied with post-procedural cardiac enzyme elevation compared with intermediate/negative remodeling in patients with acute myocardial infarction

Abstract: AMI patients with PR have more plaque vulnerability and higher frequency of plaque prolapse accompanied by post-procedural cardiac enzyme elevation compared with AMI patients with IR/NR.

Cited by 15 publications

References 59 publications

Increased glycated albumin and decreased esRAGE levels in serum are related to negative coronary artery remodeling in patients with type 2 diabetes: an Intravascular ultrasound study

Increased glycated albumin and decreased esRAGE levels in serum are related to negative coronary artery remodeling in patients with type 2 diabetes: an Intravascular ultrasound study

Visualization of coronary plaque in type 2 diabetes mellitus patients using a new 40MHz intravascular ultrasound imaging system

Roles of Intravascular Ultrasound in Patients with Acute Myocardial Infarction

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