Positive skin test and age

Forte, Wilma Carvalho Neves; Júnior, Fábio Ferreira de Carvalho; Filho, Wilson Diogo Fernandes; Shibata, Elisabete; Henriques, Luciana S.; Mastroti, Roberto Antonio; Guedes, Marilda da Silva

doi:10.2223/jped.186

Cited by 3 publications

(1 citation statement)

References 9 publications

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“…Patients underwent immediate hypersensitivity puncture skin tests to aeroallergens: Dermatophagoides pteronyssinus, D. farinae e Blomia tropicalis (FDA Allergenics ® ), taking the solution of histamine (1 mg/mL) as positive control and the excipient solution, as negative. We considered as a positive result the test that induced papular induration, whose diameter was higher than or equal to 3 mm (11) . Patients with at least one positive test were defined as atopic and those in which all results were negative, as non-atopic.…”

Section: Methodsmentioning

confidence: 99%

Broncoprovocação com solução salina hipertônica em crianças asmáticas

Costa

Lanza

Solé

2012

Rev. paul. pediatr.

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Bronchoprovocation with hypertonic saline solution in asthmatic childrenBroncoprovocação com solução salina hipertônica em crianças asmáticas Brocoprovocación con solución salina hipertónica en niños asmáticos ABSTRACT Objective: To verify if the bronchoprovocation test with 4.5% hypertonic saline solution allows to detect the gradient of response in asthmatic children and adolescents, according to asthma severity.Methods: 75 asthmatic patients aged six to 18 yearsold were evaluated in this cross-sectional study. They were classified according to asthma severity in: intermittent or mild persistent (IM) and moderate or severe persistent (MS). They were also classified according to sensitization to inhaled allergens in atopics: positive skin prick test to Dermatophagoides pteronyssinus, D. farinae and Blomia tropicalis; or non-atopic with negative skin prick tests. All patients underwent a bronchoprovocation test with 4.5% hypertonic saline solution. The result of the bronchoprovocation test was considerd positive if at least a reduction of 20% in the forced expiratory volume in one second (FEV 1 ) was noted.Results: 60 individuals were atopic. The bronchoprovocation test was positive more frequently in the MS group than in the IM one (93 versus 65%). Less time was needed for a 20% fall of FEV 1 in the MG compared to the IL group [90 (30-330) versus 210 (30-690) seconds; p<0.05]. The percentage of FEV 1 fall was higher in the MG group than in the IL one [26,4% (14-63) versus 20% (0-60); p<0.05].Conclusions: The 4.5% hypertonic saline solution bronchoprovocation test is safe and easy to perform. It detects a gradient of response in asthmatic children and adolescents regarding asthma severity. Higher frequency of positive tests, shorter time for FEV 1 fall, and higher percentage of FEV 1 fall were observed in moderate and severe asthmatic patients.Objetivo: Verificar se o teste de broncoprovocação, com solução salina hipertônica a 4,5%, permite detectar o gradiente de resposta em crianças e adolescentes com asma, segundo a gravidade da enfermidade.Métodos: Estudo transversal composto por 75 pacientes asmáticos com idades entre seis e 18 anos. Os pacientes foram classificados pela gravidade (intermitente associada à persistente leve -IL, e persistente moderada associada à grave -MG) e segundo a presença de sensibilização a aeroalérgenos (testes cutâneos de hipersensibilidade imediata a Dermatophagoides pteronyssinus, D. farinae e Blomia tropicalis) ou não (atópicos versus não atópicos). Todos foram submetidos ao teste de broncoprovocação com solução salina hipertônica a 4,5%, considerando-se o resultado positivo se havia redução do volume expiratório forçado no primeiro segundo (VEF 1 ) ≥20%.Resultados: 60 indivíduos eram atópicos. A frequência de positividade do teste de broncoprovocação foi maior no Grupo MG do que no IL (93 versus 65%). O tempo necessário para a queda de 20% do VEF 1 para o grupo de atópicos foi menor no MG quando comparado ao IL: 90 (30-330) versus 210 (30-690) segundos, com p<0,05. A porcentagem...

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Section: Methodsmentioning

confidence: 99%

Broncoprovocação com solução salina hipertônica em crianças asmáticas

Costa

Lanza

Solé

2012

Rev. paul. pediatr.

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Skin test hypersensitivity for childhood asthma in Istanbul during a period of 16 years

Akçakaya

Çokuğraş

Camcioğlu

et al. 2005

Allergologia et Immunopathologia

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Exames Para Avaliar a Sensibilização Ao Aspergillus Fumigatus Em Fibrose Cística

Aguiar

Damaceno

Forte³

2017

Rev. paul. pediatr.

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Objective: To evaluate the results of the tests used to identify the IgE mediated sensitization to Aspergillus fumigatus in patients with cystic fibrosis.Methods: This is a cross-sectional descriptive study with a convenience sample of 86 patients diagnosed with cystic fibrosis in the Reference Service in Cystic Fibrosis at a tertiary teaching hospital. The following tests were performed to assess the sensitization to A. fumigatus in patients with cystic fibrosis: Total serum IgE, eosinophil count, fungus detection through oropharyngeal swab or sputum culture, serum-specific IgE, and immediate-type hypersensitivity (IgE) skin tests. We compared the results of the different tests performed.Results: In 33 (38.4%) patients with cystic fibrosis, with ages ranging from 1 to 33 years (median of 8 years), the IgE-mediated A. fumigatus sensitization test results were: in 16 patients, there was an increase in serum-specific IgE (>0.35 kU/L); in 23, skin tests were positive; and six had sensitization in both tests. We observed two patients with eosinophilia (>1,000 eosinophils/mm3) and seven with increasing total serum IgE (>1,000 IU/mL), all of whom obtained negative results in skin tests and had no IgE increase specific to A. fumigatus. A. fumigatus was not detected in oropharyngeal swabs and/or sputum culture of any patients.Conclusions: We conclude that, among the tests used to assess sensitization to A. fumigatus in cystic fibrosis patients, both serum-specific IgE and immediate-type hypersensitivity (IgE) skin tests are required. Serum eosinophilia and respiratory secretion culture were not essential in this study.

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Positive skin test and age

Cited by 3 publications

References 9 publications

Broncoprovocação com solução salina hipertônica em crianças asmáticas

Broncoprovocação com solução salina hipertônica em crianças asmáticas

Skin test hypersensitivity for childhood asthma in Istanbul during a period of 16 years

Exames Para Avaliar a Sensibilização Ao Aspergillus Fumigatus Em Fibrose Cística

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