We study the second order nonlinear differential equationwhere αi, βj > 0, ai(x), bj(x) are non-negative Lebesgue integrable functions defined in [0, L], and the nonlinearities gi(s), kj(s) are continuous, positive and satisfy suitable growth conditions, as to cover the classical superlinear equation u + a(x)u p = 0, with p > 1. When the positive parameters βj are sufficiently large, we prove the existence of at least 2 m − 1 positive solutions for the Sturm-Liouville boundary value problems associated with the equation. The proof is based on the Leray-Schauder topological degree for locally compact operators on open and possibly unbounded sets. Finally, we deal with radially symmetric positive solutions for the Dirichlet problems associated with elliptic PDEs. * Work supported by the Gruppo Nazionale per l'Analisi Matematica, la Probabilità e le loro Applicazioni (GNAMPA) of the Istituto Nazionale di Alta Matematica (INdAM). Progetto di Ricerca 2016: "Problemi differenziali non lineari: esistenza, molteplicità e proprietà qualitative delle soluzioni".