Existence of positive solutions for the nonlinear fractional differential equation D α u = f (x, u), 0 < α < 1 has been given (S. Zhang, J. Math. Anal. Appl. 252 (2000), [804][805][806][807][808][809][810][811][812] where D α denotes Riemann-Liouville fractional derivative. In the present work we extend this analysis for n-term non autonomous fractional differential equations. We investigate existence of positive solutions for the following initial value problem:with initial conditions u(0) = 0, [D α−n+1 u(x)] x=0 = b n−1 0, [D α−n+j u(x)] x=0 = b n−j , b n−j j −1 k=1 a k b k+n−j , j = 2, 3, . . . , n − 1, n − 1 < α < n,n ∈ IN where L(D) = D α − n−1 j =1 a j D α−j , a j > 0, ∀j, D α−j is the standard Riemann-Liouville fractional derivative. Further the conditions on a j 's and f, under which the solution is (i) unique and (ii) unique and positive as well, are given.