We give some necessary and sufficient conditions for the existence of C 2 ½0, 1 and C 3 ½0, 1 positive solutions to the singular boundary value problem y 0000 ðtÞ ¼ pðtÞy ðtÞ, t 2 ð0, 1Þ,where: 2 ð0, 1Þ is given; and p : ð0, 1Þ ! ½0, 1Þ can be singular at both ends t ¼ 0 and t ¼ 1. We also give a sufficient condition for the existence of C 1 ½0, 1 positive solutions to the above problem. The proofs are based upon the method of lower and upper solutions for singular fourth-order boundary value problems.