Positive temporal sharp waves in electroencephalograms of the premature newborn

Vecchierini-Blineau, M.F.; Nogues, B; Louvet, Samuel; Desfontaines, O

doi:10.1016/s0987-7053(97)89149-6

Cited by 26 publications

(15 citation statements)

References 18 publications

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“…These EEG transients were low-to moderate-amplitude events similar to the subtle, brief spikes and waveforms observed in preterm infants (Scher et al 1994). Clinically, the frequency of such epileptiform EEG transients is strongly associated overall with poor outcome (Biagioni et al 2000;Hughes and Guerra 1994;Marret et al 1997;Okumura et al 2003;Rowe et al 1985;Vecchierini-Blineau et al 1996).…”

Section: Introductionmentioning

confidence: 84%

Differential Effects of Hypothermia on Early and Late Epileptiform Events After Severe Hypoxia in Preterm Fetal Sheep

Dean¹,

Wassink²,

Gunn³

2007

Journal of Neurophysiology

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Section: Introductionmentioning

confidence: 84%

Differential Effects of Hypothermia on Early and Late Epileptiform Events After Severe Hypoxia in Preterm Fetal Sheep

Dean¹,

Wassink²,

Gunn³

2007

Journal of Neurophysiology

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“…Temporal sharp waves may also appear in the EEG during the first weeks of life in infants born at 31-32 weeks gestation. However, if abundant, or persisting, they are associated with brain injury, figure 1 10 . There are also other EEG features that have been observed and associated with normal or abnormal outcome in preterm infants.…”

Section: Introductionmentioning

confidence: 99%

Electroencephalography and brain damage in preterm infants

Hellström‐Westas

Rosén

2005

Early Human Development

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Electroencephalography (EEG) is a sensitive method for detection of brain injury in preterm infants. Although the acute and chronic EEG changes are mainly non-specific regarding type of injury, they correlate with later neurological and cognitive function. In infants developing periventricular hemorrhagic or ischemic brain injury, acute EEG findings include depression of background activity and presence of epileptic seizure activity. The chronic EEG changes associated with white matter injury and abnormal neurological development include delayed maturation, and presence of abundant rolandic sharp waves. Suboptimal cognitive development in preterm infants has been associated with changes in various sleep measures in EEG's recorded at full term. Continuous EEG-monitoring during neonatal intensive careshows that cerebral electrical activity during this vulnerable period can be affected by several extracerebral factors, e.g. cerebral blood flow, acidosis and some commonly used medications. For diagnosis of brain injury in preterm infants with neurophysiological methods, a combination of early continuous EEG monitoring during the initial intensive care period and full EEG, performed at later stages, is probably optimal.Key words: EEG, aEEG, Cerebral Function Monitor, preterm, brain injuryThe normal EEG of the very preterm infantOur knowledge about what can be considered as a normal early postnatal EEG in an extremely preterm infant has increased considerably during the last few years. Such studies of extremely preterm infants are methodologically difficult to perform, not least due to the vulnerability of these infants during the first days of life, and the study populations are consequently relatively small. Nevertheless, a few studies have managed to include very immature infants with no intracranial pathology on cranial ultrasound or magnetic resonance imaging and with normal long-term follow up. Postconceptional age (PCA) is a commonly used term in EEG studies for describing the infant's degree of maturation. It is often defined as gestational age (GA) in weeks at delivery plus postnatal age in weeks. However, some authors use other terms, e.g. conceptional age and postmenstrual age. In this review we have chosen to use the authors' own terminology regarding the infant's maturity. Extrauterine life is not a normal condition in preterm infants, and therefore data on "normal" postnatal development of EEG in extremely preterm infants is lacking. Serial EEG's of preterm infants without brain lesions and who developed normally give the closest approximation of normal EEG development. However, some studies from healthy preterm infants indicate that some features of the EEG, especially regarding sleep-state variables, at full-term may differ from the EEG's of newborns born at normal gestations 1,2 . Magnetoencephalography (MEG) is an advanced non-invasive method that can be performed on normal intrauterine fetuses. It is likely that MEG-data in the future can add knowledge on the normal neurophysiological develo...

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“…(PTSWs) are not associated with a poor outcome when they are few in number, short in duration, low in amplitude, and regress rapidly [82] ( Fig. 8 ).…”

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confidence: 97%

“…8 ). In a study by Vecchierini-Blineau et al [82] , the characteristics of PTSWs were described in both healthy and sick infants born between 31 and 32 weeks' GA. Features in the pathological group differed significantly from the healthy group, with a duration longer than 171.3 ± 34.9 ms, an amplitude higher than 125.6 ± 26.5 μV, and a frequency of 0.25 ± 0.18/min (only in infants with asphyxia) [82] .…”

mentioning

confidence: 99%

“…In a study by Vecchierini-Blineau et al [82] , the characteristics of PTSWs were described in both healthy and sick infants born between 31 and 32 weeks' GA. Features in the pathological group differed significantly from the healthy group, with a duration longer than 171.3 ± 34.9 ms, an amplitude higher than 125.6 ± 26.5 μV, and a frequency of 0.25 ± 0.18/min (only in infants with asphyxia) [82] . Furthermore, the incidence of the PTSWs was lower in the healthy infants, and they decreased rapidly during the 2nd week of life in this population compared to the pathological group where they tended to persist [82] .…”

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confidence: 99%

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EEG - A Valuable Biomarker of Brain Injury in Preterm Infants

Pavlidis¹,

Lloyd²,

Boylan³

2017

Dev Neurosci

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This review focuses on the role of electroencephalography (EEG) in monitoring abnormalities of preterm brain function. EEG features of the most common developmental brain injuries in preterm infants, including intraventricular haemorrhage, periventricular leukomalacia, and perinatal asphyxia, are described. We outline the most common EEG biomarkers associated with these injuries, namely seizures, positive rolandic sharp waves, EEG suppression/increased interburst intervals, mechanical delta brush activity, and other deformed EEG waveforms, asymmetries, and asynchronies. The increasing survival rate of preterm infants, in particular those that are very and extremely preterm, has led to a growing demand for a specific and shared characterization of the patterns related to adverse outcome in this unique population. This review includes abundant high-quality images of the EEG patterns seen in premature infants and will provide a valuable resource for everyone working in developmental neuroscience.

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Positive temporal sharp waves in electroencephalograms of the premature newborn

Cited by 26 publications

References 18 publications

Differential Effects of Hypothermia on Early and Late Epileptiform Events After Severe Hypoxia in Preterm Fetal Sheep

Differential Effects of Hypothermia on Early and Late Epileptiform Events After Severe Hypoxia in Preterm Fetal Sheep

Electroencephalography and brain damage in preterm infants

EEG - A Valuable Biomarker of Brain Injury in Preterm Infants

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