Positivity of celiac disease–specific antibodies and non-celiac hypersensitivity in psoriasis

Vekić-Mužević, Marina; Tomić, Lucija; Pondeljak, Nives; Lazić Mosler, Elvira

doi:10.15570/actaapa.2023.18

Cited by 1 publication

(1 citation statement)

References 37 publications

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“…Anti-DGP positivity is recognized in some CD cases with a negative TTG IgA testing and normal IgA [ 77 ] and can represent an early preclinical biomarker predicting CD onset [ 78 ]. Moreover, anti-DGP have potential advantages over other conventionally used assays in milder forms of enteropathy associated with gluten-sensitive skin disorder and have been detected more frequently and at higher serum concentrations in patients with autoimmune skin disorders compared to healthy controls [ 79 ]. However, an isolated increase in anti-DGP in patients with negative conventional CD serological testing has a very low predictive value [ 77 ].…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Disorders Masking Celiac Disease: Case Report and Mini Review with Proposal for a Practical Clinical Approach

Ancona,

Bianchin,

Zampatti

et al. 2023

Nutrients

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Celiac disease (CD) is an immune-mediated systemic gluten-related disorder characterized by a wide spectrum of intestinal and extra-intestinal manifestations, including damage to cutaneous and connective tissue. We report a rare case of chronic severe dermatitis involving connective tissue and cutaneous vascular vessels as the main clinical presentation of undiagnosed seronegative gluten disorder. A gluten-free diet dramatically improved the intestinal and cutaneous clinical damage in the patient. Pitfalls and the steps of differential diagnosis are described. We also review the literature regarding studies of CD and connective tissue diseases to extend the knowledge of these rare associations. We propose a practical diagnostic approach in suspected CD in autoimmune cutaneous disorders.

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