Positron emission tomography and histopathology in Pick's disease

Kamo, H.; McGeer, Patrick L.; Harrop, R.; McGeer, Edith G.; Calne, D. B.; Martin, W. R. Wayne; Pate, B. D.

doi:10.1212/wnl.37.3.439

Cited by 122 publications

(29 citation statements)

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“…In addition, the present study suggests that dementia in CBD may be associated with degeneration in the iPF cortex. Our CBD patients exhibited hypoperfusion in the inferior and medial frontal regions which frequently are damaged in Pick's disease as well [22,23]. Thus, it looks likely that CBD and Pick's disease, at least in part, share the underlying mechanism of cognitive decline.…”

Section: Discussionmentioning

confidence: 93%

Comparison of Brain Perfusion in Corticobasal Degeneration and Alzheimer’s Disease

Okuda

Tachibana²,

Kawabata³

et al. 2001

Dement Geriatr Cogn Disord

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To compare brain perfusion between corticobasal degeneration (CBD) and Alzheimer’s disease (AD), we measured regional cerebral blood flow (rCBF) semiquantitatively with single-photon emission computed tomography in 10 patients with CBD and 16 with AD. There was no significant difference in age or illness duration between the patients with CBD and AD. Mini-Mental State Examination scores were significantly lower in the AD patients than in the CBD patients. All CBD patients showed asymmetric akinetic-rigid syndrome and limb apraxia. Four CBD patients were demented, and 1 AD patient had parkinsonism. Compared with 12 age-matched control subjects, the average of the left and right rCBF values for the CBD patients was significantly reduced in the prefrontal, anterior cingulate (AC), medial premotor, sensorimotor (SM), posterior parietal (PP) and superior temporal (ST) cortices as well as in the basal ganglia (BG) and thalamus (Th), while the prefrontal, PP and ST cortices were significantly hypoperfused in the AD patients. In the CBD patients, rCBF was significantly less in the AC and SM cortices, and in the Th and BG, and significantly greater in the PP cortex than in the AD patients. Interhemispheric differences of rCBF in the inferior prefrontal and SM cortices were significantly greater in the CBD patients than the AD patients. It is concluded that rCBF comparison may aid in differentiating CBD from AD.

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Section: Discussionmentioning

confidence: 93%

Comparison of Brain Perfusion in Corticobasal Degeneration and Alzheimer’s Disease

Okuda

Tachibana²,

Kawabata³

et al. 2001

Dement Geriatr Cogn Disord

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“…Frontotemporal dementia is characterized by alterations in cerebral metabolism in the anterior cerebral regions, the metabolism in posterior association cortices being relatively preserved [29, 30, 31]. There is a notion of heterogeneity and subgroup formation in FTD, depending on the presence of language and speech disorders, motor abnormalities and the patterns of behavioral alterations.…”

Section: Discussionmentioning

confidence: 99%

Differential Regional Cerebral Uptake of <sup>18</sup>F-Fluoro-2-Deoxy-<i>D</i>-Glucose in Alzheimer’s Disease and Frontotemporal Dementia at Initial Diagnosis

Santens¹,

Bleecker²,

Goethals³

et al. 2001

Eur Neurol

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In this paper, the cerebral uptake of ¹⁸F-fluoro-2-deoxy-D-glucose (FDG) was studied in a relatively small group of patients suffering from either clinically diagnosed Alzheimer’s disease (AD) or frontotemporal dementia during the initial differential diagnostic workup. The image analysis was done visually and semiquantitatively using three different reference regions. Visual analysis confirmed earlier literature findings on the distribution of decreased FDG uptake and demonstrated prevalent asymmetric patterns in both groups. Only semiquantitative analysis using the sensorimotor cortex as a reference region confirmed the visual findings. Moreover, there were no differences in medial temporal lobe activities between both groups, and there was no correlation of medial temporal lobe activity with dementia severity. In the AD group, a correlation of parietal FDG uptake with MMSE scores was found.

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“…This frontal hypoperfusion predicted the frontal pathology that characterizes FTD. Others confirmed these observations [17][18][19][20][21][22][23], and quantitative studies with positron emission tomography (PET) showed that patients with Pick's disease had diminished frontal lobe glucose uptake suggesting altered neuronal metabolism in the anterior brain regions [24][25][26][27][28]. Yet, despite these elegant clinical and imaging studies which should have allowed accurate diagnosis of FTD, the misdiagnosis rate for this condition has remained high [14].…”

Section: Historical Reviewmentioning

confidence: 97%

Neuroimaging in the Diagnosis of Frontotemporal Dementia

Miller¹,

Gearhart²

1999

Dement Geriatr Cogn Disord

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The role of neuroimaging for the diagnosis of frontotemporal dementia (FTD) remains controversial. The modern history of imaging in the study of FTD is outlined. Also, the findings on MRI and SPECT in 15 consecutive FTD patients is noted. Both MRI and SPECT detected focal frontal involvement in nearly every single case (MRI 14/15 and SPECT 15/15). Also, the majority of patients showed asymmetry on MRI (8/15) and SPECT (12/15). This study confirms that neuroimaging is sensitive to the frontotemporal degeneration associated with FTD. Additionally, it suggests that this is often asymmetric in the relative involvement of these brain regions.

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Positron emission tomography and histopathology in Pick's disease

Cited by 122 publications

References 0 publications

Comparison of Brain Perfusion in Corticobasal Degeneration and Alzheimer’s Disease

Comparison of Brain Perfusion in Corticobasal Degeneration and Alzheimer’s Disease

Differential Regional Cerebral Uptake of <sup>18</sup>F-Fluoro-2-Deoxy-<i>D</i>-Glucose in Alzheimer’s Disease and Frontotemporal Dementia at Initial Diagnosis

Neuroimaging in the Diagnosis of Frontotemporal Dementia

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