Positron emission tomography/computed tomography for osseous and soft tissue sarcomas: A systematic review of the literature and meta-analysis

Muheremu, Aikeremujiang; Ma, Jingfei; Amudong, Aierken; Ma, Yong; Niyazi, Maimaitiaili; Ou, Yvonne; Ma, Yuan

doi:10.3892/mco.2017.1329

Cited by 13 publications

(9 citation statements)

References 29 publications

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“…For this reason, in addition to CT‐scan of the chest for LM screening, lymphnode dissection is mandatory when lymphnode involvement is suspected by diagnostic imaging . For this purpose, positron emission tomography in combination with CT‐scan was proposed as a reliable imaging method …”

Section: Discussionmentioning

confidence: 99%

Can radical margins improve prognosis in primary and localized epithelioid sarcoma of the extremities?

Sambri

Bianchi

Cevolani

et al. 2017

Journal of Surgical Oncology

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Section: Discussionmentioning

confidence: 99%

Can radical margins improve prognosis in primary and localized epithelioid sarcoma of the extremities?

Sambri

Bianchi

Cevolani

et al. 2017

Journal of Surgical Oncology

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“…On the other hand, dedicated FDG-PET was more sensitive in the diagnosis of soft tissue sarcomas. To elucidate the value of PET/CT, Muheremu et al [29] pooled the data of 16 trials and concluded that PET combined with CT is a reliable imaging method to be applied in the diagnosis of osseous and soft tissue malignancies. New diagnostic modalities including PET-MRI combinations have been investigated.…”

Section: Discussionmentioning

confidence: 99%

Meta-Analysis of the Diagnostic Accuracy of Primary Bone and Soft Tissue Sarcomas by <sup>18</sup>F-FDG-PET

et al. 2019

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Highlights of the Study • Some sarcomas present substantial diagnostic challenges that demand accurate diagnostic modalities. • We performed a meta-analysis of available evidence and found the pooled sensitivity and specificity of FDG-PET combined with CT for the detection of sarcomas to be 89.2 and 76.3%, respectively, i.e., higher than those of FDG-PET alone. • FDG-PET can efficiently differentiate between benign and malignant tumors, with a mean standard uptake value of maximally 2.52 units in benign and 6.81 units in malignant tumors with 89.2% sensitivity and 75.1% specificity.

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“…One review found FDG-PET/CT contributed to determining the final causal diagnosis in FUO in 38–75% of cases [8]. In addition, a systematic review examining data from 16 trials found that PET/CT imaging was 90% sensitive and 89% specific for overall diagnostic accuracy in osseous and STSs [9]. However, this imaging modality was not utilized in this case.…”

Section: Discussionmentioning

confidence: 99%

Undifferentiated epithelioid sarcoma presenting as a fever of unknown origin: a case report

2019

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BackgroundFever of unknown origin is often a diagnostic dilemma for clinicians due to its extremely broad differential. One of the rarer categories of disease causing fever of unknown origin is malignancies; of these, soft tissue sarcoma is one of the least common. Soft tissue sarcomas make up < 1% of all adult malignancies and often do not present with any systemic manifestations or neoplastic fevers.Case presentationA 73-year-old Caucasian woman presented with a 2-week history of fever and profound fatigue. The only other symptom she endorsed was a transient history of left knee pain, initially thought to be unrelated. There was no clear cause on initial examination and routine investigations, but her C-reactive protein was significantly elevated at 207 mg/L. Blood cultures and a urine culture were drawn. She was admitted to hospital for further investigation and placed on empiric antibiotics. Her blood cultures were negative, but she had one further fever in hospital. Computed tomography scans did not yield a cause of her fever. No vegetations were seen on echocardiography. Antibiotics were stopped as she did not seem to have an acute infectious cause of her fever. No new symptoms developed. She felt well enough to proceed with out-patient follow up and was discharged after 8 days in hospital. At 1-month post-discharge: no resolution of symptoms, but she endorsed a recurrence of her left knee pain. Ultrasound and magnetic resonance imaging revealed a 4.5 × 6.8 × 11.6 cm soft tissue mass, identified as a sarcoma on biopsy. She subsequently underwent a distal femur resection. Final staging was pT2bN0M0. She underwent adjuvant radiation therapy, but was found to have developed metastatic disease.ConclusionThis case revealed an atypical presentation of a rare soft tissue sarcoma as the cause of the illness. The etiology behind a fever of unknown origin can be difficult to elucidate, making the approach to investigation particularly important. Repeated history-taking and serial physical examinations can be crucial in guiding investigations and ultimately arriving at a diagnosis. In addition, we believe this case highlights the adage that no seemingly innocuous symptom should be left out when working up a condition with such an extensive and complex differential.

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Positron emission tomography/computed tomography for osseous and soft tissue sarcomas: A systematic review of the literature and meta-analysis

Cited by 13 publications

References 29 publications

Can radical margins improve prognosis in primary and localized epithelioid sarcoma of the extremities?

Can radical margins improve prognosis in primary and localized epithelioid sarcoma of the extremities?

Meta-Analysis of the Diagnostic Accuracy of Primary Bone and Soft Tissue Sarcomas by <sup>18</sup>F-FDG-PET

Undifferentiated epithelioid sarcoma presenting as a fever of unknown origin: a case report

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