Positron emission tomography for initial staging of esophageal cancer among medicare beneficiaries

Simianu, Vlad V.; Varghese, Thomas K.; Flanagan, Meghan R.; Flum, David R.; Shankaran, Veena; Oelschlager, Brant K.; Mulligan, Michael S.; Wood, Douglas E.; Farjah, Farhood

doi:10.21037/jgo.2015.10.03

Cited by 2 publications

(3 citation statements)

References 30 publications

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“…Positron emission tomography combined with computed tomography (PET/CT) is widely used for staging and tumour response assessment in oncology. 1 , 2 , 3 PET/CT provides both metabolic and anatomic information and allows detection, localization and characterization of the lesions. 4 , 5 In the majority of PET/CT scanners image reconstruction is traditionally performed using the 4 mm in-line pixel size (4 x 4 x 4 mm voxel).…”

Section: Introductionmentioning

confidence: 99%

Image reconstruction using small-voxel size improves small lesion detection for positron emission tomography

Rep

Tomše

Jensterle

et al. 2022

Radiology and Oncology

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Background PET/CT imaging is widely used in oncology and provides both metabolic and anatomic information. Because of the relatively poor spatial resolution of PET, the detection of small lesions is limited. The low spatial resolution introduces the partial-volume effect (PVE) which negatively affects images both qualitatively and quantitatively. The aim of the study was to investigate the effect of small-voxel (2 mm in-line pixel size) vs. standard-voxel (4 mm in-line pixel size) reconstruction on lesion detection and image quality in a range of activity ratios. Materials and methods The National Electrical Manufacturers Association (NEMA) body phantom and the Micro Hollow-Sphere phantom spheres were filled with a solution of [18F]fluorodeoxyglucose ([18F]FDG) in sphere-to-background ratios of 2:1, 3:1, 4:1 and 8:1. In all images reconstructed with 2 mm and 4 mm in-line pixel size the visual lesion delineation, contrast recovery coefficient (CRC) and contrast-to-noise ratio (CNR) were evaluated. Results For smaller (≤ 13 mm) phantom spheres, significantly higher CRC and CNR using small-voxel reconstructions were found, also improving visual lesion delineation. CRC did not differ significantly for larger (≥ 17 mm) spheres using 2 mm and 4 mm in-line pixel size, but CNR was significantly lower; however, lower CNR did not affect visual lesion delineation. Conclusions Small-voxel reconstruction consistently improves precise small lesion delineation, lesion contrast and image quality.

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Section: Introductionmentioning

confidence: 99%

Image reconstruction using small-voxel size improves small lesion detection for positron emission tomography

Rep

Tomše

Jensterle

et al. 2022

Radiology and Oncology

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show abstract

“…We also determined CNR mean/maximum, as a measure of the signal level in the presence of noise: Eq.(A. 2) where SUV is a mean/maximum measured FDG SUV in the phantom spheres, BGa is the average measured SUV in the background and SDbg is the standard deviation of the SUV in the background.…”

Section: Methodsmentioning

confidence: 99%

“…Positron emission tomography combined with computed tomography (PET/CT) is widely used for staging and tumor response assessment in oncology [1], [2], [3]. PET/CT provides both metabolic and anatomic information and allows detection, localization and characterization of the lesions [4], [5].…”

Section: Introductionmentioning

confidence: 99%

PET/CT NEMA Body Phantom Image Reconstruction Study Using 2 mm Voxel Size for Improved Image Quality

Rep¹,

Tomše²,

Jensterle³

et al. 2021

Preprint

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Background PET/CT imaging is widely used in oncology and provides both metabolic and anatomic information. Because of the relatively poor spatial resolution of PET/CT imaging technique the detection of small lesions is limited. The low spatial resolution introduces the partial-volume effect (PVE) which negatively affects images both visually and quantitatively. The aim of our research was to investigate the effect of 4 mm and 2 mm voxel size on image quality and on detection of small spheres. MethodsWe used the NEMA body phantom with six fillable spheres. The spheres and background were filled with a solution of 18F-FDG, in ratio spheres vs background 2:1, 3:1, 4:1 and 8:1 In all images reconstructed with 2 mm and 4 mm voxel size the contrast recovery coefficient (CRC), contrast to noise ratio (CNR) in standardized uptake value (SUV) were evaluated.ResultsFor phantom spheres ≤ 13 mm, we found significant higher CRC, SUV and CNR using small-voxel reconstructions. CRC and SUV did not differ for large spheres (≥ 17 mm) using 2 mm and 4 mm voxel size. On the other hand, CNR for large spheres (≥ 17 mm) was significantly decreased in 2 mm voxel size images compared to the 4 mm.ConclusionAccording to our results, the reconstruction with 2 mm voxel size can improve precise lesion localization, image contrast, and image quality.

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Positron emission tomography for initial staging of esophageal cancer among medicare beneficiaries

Cited by 2 publications

References 30 publications

Image reconstruction using small-voxel size improves small lesion detection for positron emission tomography

Image reconstruction using small-voxel size improves small lesion detection for positron emission tomography

PET/CT NEMA Body Phantom Image Reconstruction Study Using 2 mm Voxel Size for Improved Image Quality

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