Positron emission tomography helps to diagnose tumor emboli and residual disease in choriocarcinoma

Hebart, Holger; Erley, Christiane M.; Kaskas, B.; Mayer, Ramona; König, M.; Einsele, H.; Bokemeyer, Carsten; Meerpohl, H. G.; Feine, U.; Kanz, L.

doi:10.1093/oxfordjournals.annonc.a010611

Cited by 28 publications

(4 citation statements)

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“…PET is a noninvasive method for studying biochemical and metabolic changes in cancer tissue, as they reflect growth or regression of tumors. Yet, there are limited data on the efficacy of PET in the evaluation of metastatic GTN, with studies limited to case reports and small case series (11)(12)(13)(14). Sironi et al (15).…”

Section: Discussionmentioning

confidence: 99%

Gestational trophoblastic disease with pulmonary and cerebral metastasis: Can fluorodeoxyglucose positron emission tomography really detect cranial metastatic disease ?

UYSAL¹

2016

Ankara Üniversitesi Tıp Fakültesi Mecmuası

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Gestational trophoblastic neoplasms (GTN) originate from placental tissue and usually metastasizes because of its propensity for early vascular invasion. Intracranial metastases are relatively uncommon. There are limited data on the efficacy of 18-fluorodeoxyglucose positron emission tomography (FDG-PET) in the evaluation of metastatic GTN. We present a case of GTN with simultaneous pulmonary and cranial metastases in which the cranial metasteses were undetectable with positron emission tomography (PET) scan.Key Words: Gestational Trophoblastic Neoplasms, Cranial Metastasis, Positron Emission Tomography Gestasyonel Trofoblastik Neoplaziler (GTN) plasenta dokusundan köken alırlar ve erken vasküler invazyon yaptıklarından sıklıkla metastaz yaparlar. Beyin metastazı nadir görülür. Metastatik GTN'nin taranmasında 18-florodeoksiglukoz pozitron emisyon tomografisinin (FDG-PET) etkinliği konusunda veriler yetersizdir. Bu olgu sunumunda, eş zamanlı akciğer ve beyin metastazı olan ve beyin metastazının FDG-PET ile saptanamadığı bir GTN olgusunu sunuyoruz.

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Section: Discussionmentioning

confidence: 99%

Gestational trophoblastic disease with pulmonary and cerebral metastasis: Can fluorodeoxyglucose positron emission tomography really detect cranial metastatic disease ?

UYSAL¹

2016

Ankara Üniversitesi Tıp Fakültesi Mecmuası

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“…11,23 Therefore, staging 18 F-FDG PET/CT is actually performed only in high-risk GTD patients or in equivocal cases on conventional imaging. 13,20,30 However, still limited data are available, most of which obtained from studies performed on small cohorts of patients and at different phases of the disease.…”

mentioning

confidence: 99%

“…So far, few preliminary studies have investigated the potential role of 18 F-FDG PET/CT both in primary staging and in monitoring treatment for GTD 1,7,16–30 . 18 F-FDG PET/CT seems to be very useful in GTD patients with metastatic disease, particularly in those with high-risk tumors, allowing to precisely identify the sites of disease, discriminate persistent active disease and necrotic/hemorrhagic tissue after chemotherapy avoiding false-positive CT results, and guide surgical intervention and patient management 13,19,23,31–34 .…”

mentioning

confidence: 99%

“…Conversely, 18 F-FDG PET/CT has not yet demonstrated the same additional value in staging, providing no further information with respect to conventional imaging techniques, partly due to its limited spatial resolution 11,23 . Therefore, staging 18 F-FDG PET/CT is actually performed only in high-risk GTD patients or in equivocal cases on conventional imaging 13,20,30 . However, still limited data are available, most of which obtained from studies performed on small cohorts of patients and at different phases of the disease.…”

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confidence: 99%

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18F-FDG PET/CT May Predict Tumor Type and Risk Score in Gestational Trophoblastic Disease

et al. 2022

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The aim of this study was to investigate the role of 18 F-FDG PET/ CT in predicting pathological prognostic factors, including tumor type and International Federation of Gynecology and Obstetrics (FIGO) score, in gestational trophoblastic disease (GTD). Methods: Retrospective monocentric study including 24 consecutive patients who underwent to 18 F-FDG PET/CT from May 2005 to March 2021 for GTD staging purpose. The following semiquantitative PET parameters were measured from the primary tumor and used for the analysis: maximum standardized uptake value (SUV max ), SUV mean , metabolic tumor volume (MTV) and total lesion glycolisis (TLG). Statistical analysis included Spearman correlation coefficient to evaluate the correlations between imaging parameters and tumor type (nonmolar trophoblastic vs postmolar trophoblastic tumors) and risk groups (high vs low, defined according to the FIGO score), whereas area under the curve (AUC) of the receiver operating characteristic (ROC) curve was used to assess the predictive value of the PET parameters. Mann-Whitney U test was used to further describe the parameter's potential in differentiating the populations. Results: SUV max and SUV mean resulted fair (AUC, 0.783; 95% confidence interval [CI], 0.56-0.95) and good (AUC, 0.811; 95% CI, 0.59-0.97) predictors of tumor type, respectively, showing a low (ρ = 0.489, adjusted P = 0.030) and moderate (ρ = 0.538, adjusted P = 0.027) correlation. According to FIGO score, TLG was instead a fair predictor (AUC, 0.770; 95% CI, 0.50-0.99) for patient risk stratification. Conclusions: 18 F-FDG PET parameters have a role in predicting GTD pathological prognostic factors, with SUV max and SUV mean being predictive for tumor type and TLG for risk stratification.

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Germ Cell Tumors: Choricocarcinoma and Testicular Cancer

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Pet-Ct

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Positron emission tomography helps to diagnose tumor emboli and residual disease in choriocarcinoma

Abstract: WB-PET helps to localize tumor tissue in patients suffering from choriocarcinoma.

Cited by 28 publications

References 6 publications

Gestational trophoblastic disease with pulmonary and cerebral metastasis: Can fluorodeoxyglucose positron emission tomography really detect cranial metastatic disease ?

Gestational trophoblastic disease with pulmonary and cerebral metastasis: Can fluorodeoxyglucose positron emission tomography really detect cranial metastatic disease ?

18F-FDG PET/CT May Predict Tumor Type and Risk Score in Gestational Trophoblastic Disease

Germ Cell Tumors: Choricocarcinoma and Testicular Cancer

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