Positron emission tomography imaging of regional cerebral glucose metabolism

Alavi, Abass; Dann, Robert; Chawluk, J.; Alavi, Jane Β.; Kushner, Michael; Reivich, Martin

doi:10.1016/s0001-2998(86)80002-2

Cited by 117 publications

(40 citation statements)

References 87 publications

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“…This implies a decrease in glucose influx although no quantitative values can be given. Our results are in line with clinical reports, showing that after stroke, hypoxia or ischemia, the (regional) cerebral metabolic rate of glucose is decreased (Alavi et al, 1986;Mies et al, 1990;Chang and D'Alecy, 1992;Huber et al, 1993).…”

Section: Changes After Balloon Inflationsupporting

confidence: 93%

Monitoring arterio‐venous differences of glucose and lactate in the anesthetized rat with or without brain damage with ultrafiltration and biosensor technology

Leegsma-Vogt

Venema

Postema

et al. 2001

J of Neuroscience Research

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Continuous monitoring of arterio-venous glucose and lactate differences may serve as a diagnostic tool to assess normal brain function and brain pathology. We describe a method and some results obtained with arterio-venous measurements of glucose and lactate in the blood of the halothane-anesthetized rat and after brain injury. The method is based on low flow rate ultrafiltration for continuous collection of blood filtrate combined with flow injection analysis and biosensors for the detection of glucose and lactate. We measured the glucose and lactate concentration every minute in the jugular vein and the aorta at control conditions and during and after inflation of an embolectomy-balloon for 2 min. Net cerebral lactate efflux and glucose uptake was seen under control conditions and at low blood lactate levels. During brain injury both lactate release and glucose uptake were reduced and there was a net lactate influx at high arterial lactate levels. These results indicate that the flux of lactate in and out of the brain is not only dependent on the lactate concentration in the brain, but on blood levels as well, possibly because of bi-directional flux through the monocarboxylate transporter type 1.

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Section: Changes After Balloon Inflationsupporting

confidence: 93%

Monitoring arterio‐venous differences of glucose and lactate in the anesthetized rat with or without brain damage with ultrafiltration and biosensor technology

Leegsma-Vogt

Venema

Postema

et al. 2001

J of Neuroscience Research

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“…Several years ago, FDG-PET and SPECT were proposed as an aid in the diagnosis of patients with AD [11][12][13][14]. Repeatedly, studies demonstrated temporoparietal hypometabolism and reduced temporoparietal blood flow to be the typical metabolic abnormality associated with AD [15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

[<sup>18</sup>F]FDG-PET in Patients with Alzheimer’s Disease: Marker of Disease Spread

Bittner

Grön

Schirrmeister

et al. 2004

Dement Geriatr Cogn Disord

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Background: It is not known yet whether temporoparietal glucose hypometabolism in patients with probable Alzheimer’s disease (AD) reflects disease severity or different subtypes of patients. Methods: Twenty-five subjects with mild probable AD [NINCDS-ADRDA criteria; age 65.8 ± 9.3 years (mean ± SD); Mini-Mental State Examination (MMSE) 26.0 ± 3.3] were investigated. [¹⁸F]FDG-PET data were analyzed visually with raters blinded to the diagnosis and with a quantitative analysis in the region of interest on individual anatomically normalized PET scans. Results: Thirteen of 25 patients showed temporoparietal hypometabolism on visual inspection (PET+; age 65.7 ± 10.7), 12 patients had normal FDG-PET results (PET–; age 65.9 ± 8.0; n.s.). The MMSE and immediate reproduction of the Wechsler Memory Scale (WMS-R-I) were 27.7 ± 1.9 and 31.1 ± 6.1 in the PET– vs. 24.5 ± 3.6 (p = 0.012) and 22.0 ± 7.4 (p = 0.006) in the PET+ group. Immediate and delayed recall in the California Verbal Learning Test and delayed reproduction in the Wechsler Memory Scale were alike. Regression analysis revealed a significant correlation of temporoparietal glucose metabolism with the block span (r = 0.60; p < 0.01) and the WMS-R-I (r = 0.68; p < 0.01) but not with measures of hippocampal function. Conclusions: Temporoparietal glucose metabolism in patients with very mild AD is a sign of disease spread beyond the temporal lobe. This may aid in establishing objective parameters for future therapeutic studies.

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“…These investigations are frequently conducted with the help of voxel-based quantitative analysis techniques and require taking into consideration the complex physiological variations in regional brain metabolism [5,6]. In particular, the impact of age is dramatic and must be taken into account.…”

mentioning

confidence: 99%

Age-related changes in FDG brain uptake are more accurately assessed when applying an adaptive template to the SPM method of voxel-based quantitative analysis

Gucht¹,

Verger

Guedj

et al. 2015

Ann Nucl Med

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Positron emission tomography imaging of regional cerebral glucose metabolism

Cited by 117 publications

References 87 publications

Monitoring arterio‐venous differences of glucose and lactate in the anesthetized rat with or without brain damage with ultrafiltration and biosensor technology

Monitoring arterio‐venous differences of glucose and lactate in the anesthetized rat with or without brain damage with ultrafiltration and biosensor technology

[<sup>18</sup>F]FDG-PET in Patients with Alzheimer’s Disease: Marker of Disease Spread

Age-related changes in FDG brain uptake are more accurately assessed when applying an adaptive template to the SPM method of voxel-based quantitative analysis

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