Positron emission tomography in ischemic heart disease

Santos, Beatriz; Ferreira, Maria João

doi:10.1016/j.repc.2019.02.011

Cited by 21 publications

(7 citation statements)

References 64 publications

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“…Observational evidence suggests that [ 18 F]FDG-PET has the greatest sensitivity in predicting global LV functional recovery following revascularisation, compared with other imaging modalities [ 16 ]. On the other hand, techniques such as cardiac MR and stress-echocardiography may show a higher specificity [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Hybrid PET/MR imaging for the prediction of left ventricular recovery after percutaneous revascularisation of coronary chronic total occlusions

Vitadello

Kunze

Nekolla

et al. 2020

Eur J Nucl Med Mol Imaging

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Purpose To evaluate myocardial viability assessment with hybrid 2-deoxy-2-[ 18 F]fluoro- d -glucose positron emission tomography/magnetic resonance imaging ([ 18 F]FDG-PET/MR) in predicting left ventricular (LV) wall motion recovery after percutaneous revascularisation of coronary chronic total occlusion (CTO). Methods and results Forty-nine patients with CTO and corresponding wall motion abnormality (WMA) underwent [ 18 F]FDG-PET/MR imaging for viability assessment prior to percutaneous revascularisation. After 3–6 months, 23 patients underwent follow-up MR to evaluate wall motion recovery. In total, 124 segments were assigned to the CTO territories, while 80 segments displayed impaired wall motion. Of these, 68% (54) were concordantly viable in PET and MR; conversely, only 2 segments (2%) were assessed non-viable by both modalities. However, 30% showed a discordant viability pattern, either PET non-viable/MR viable (3 segments, 4%) or PET viable/MR non-viable (21 segments, 26%), and the latter revealed a significant wall motion improvement at follow-up ( p = 0.033). Combined imaging by [ 18 F]FDG-PET/MR showed a fair accuracy in predicting myocardial recovery after CTO revascularisation (PET/MR area under ROC curve (AUC) = 0.72, p = 0.002), which was superior to LGE-MR (AUC = 0.66) and [ 18 F]FDG-PET (AUC = 0.58) alone. Conclusion Hybrid PET/MR imaging prior to CTO revascularisation predicts more accurately the recovery of dysfunctional myocardium than PET or MR alone. Its complementary information may identify regions of viable myocardium with increased potential for functional recovery.

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Section: Discussionmentioning

confidence: 99%

Hybrid PET/MR imaging for the prediction of left ventricular recovery after percutaneous revascularisation of coronary chronic total occlusions

Vitadello

Kunze

Nekolla

et al. 2020

Eur J Nucl Med Mol Imaging

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“…It uses radiotracers to produce images of radionuclide distribution. These tracers can provide information on biological pathways via a noninvasive method [ 49 ].…”

Section: Medical Imagingmentioning

confidence: 99%

Application of Nanomaterials in Biomedical Imaging and Cancer Therapy

2020

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Nanomaterials, such as nanoparticles, nanorods, nanosphere, nanoshells, and nanostars, are very commonly used in biomedical imaging and cancer therapy. They make excellent drug carriers, imaging contrast agents, photothermal agents, photoacoustic agents, and radiation dose enhancers, among other applications. Recent advances in nanotechnology have led to the use of nanomaterials in many areas of functional imaging, cancer therapy, and synergistic combinational platforms. This review will systematically explore various applications of nanomaterials in biomedical imaging and cancer therapy. The medical imaging modalities include magnetic resonance imaging, computed tomography, positron emission tomography, single photon emission computerized tomography, optical imaging, ultrasound, and photoacoustic imaging. Various cancer therapeutic methods will also be included, including photothermal therapy, photodynamic therapy, chemotherapy, and immunotherapy. This review also covers theranostics, which use the same agent in diagnosis and therapy. This includes recent advances in multimodality imaging, image-guided therapy, and combination therapy. We found that the continuous advances of synthesis and design of novel nanomaterials will enhance the future development of medical imaging and cancer therapy. However, more resources should be available to examine side effects and cell toxicity when using nanomaterials in humans.

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“…Entretanto, apesar dos estudos demonstrarem que a redução de LDL-c através de uso de medicamentos reduz essas mesmas placas ateroscleróticas, os dados que avaliam se a regressão da placa está associada a eventos cardiovasculares reduzidos são limitados. Isso significa que, embora essa associação possa estar presente, não há evidências diretas de que a regressão da placa Brazilian Journal of Health Review, Curitiba, v. 6, n. 3, p. 13172-13188, mai./jun., 2023 esteja ligada à redução de eventos cardiovasculares (SANTOS;FERREIRA, 2019, DAWSON et al, 2022.…”

Section: Prognósticounclassified

Doença Cardíaca Isquêmica: aspectos epidemiológicos, fisiopatológicos e manejo terapêutico

Braga,

Rabelo,

Lacerda

et al. 2023

Braz. J. Hea. Rev.

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A Doença Cardíaca Isquêmica (DCI) é uma condição que ocorre quando o fluxo sanguíneo para o coração é reduzido ou bloqueado, geralmente devido à obstrução das artérias coronárias. Múltiplos fatores, como hipertensão arterial sistêmica, diabetes, tabagismo, sedentarismo e obesidade, favorecem a disfunção endotelial e aumentam a permeabilidade arterial à adesão e depósito de moléculas de colesterol. A principal casa da CDI é a aterosclerose, formação de placa ateromatosa na túnica íntima das artérias. Porém, o infarto do miocárdio com artérias coronárias não obstrutivas (IMACNO) também é uma causa importante da CDI. Quanto às manifestações clínicas, incluem angina, dispneia aos esforços, fadiga, palpitações e sintomas como náuseas, vômitos, sudorese, síncope. O diagnóstico da CMD envolve avaliação clínica, exames laboratoriais, eletrocardiograma, teste ergométrico, ecocardiograma transtorácico e angiografia coronária. Já a abordagem terapêutica tem como objetivo controlar os sintomas, controle dos fatores de risco e prevenção de fenômenos cardiovasculares. A abordagem farmacológica utiliza medicamentos, como anti plaquetários, estatinas e betabloqueadores, para reduzir os fatores de risco e prevenir a progressão da doença, além de intervenções não medicamentosas, como a Intervenção Coronária Percutânea (ICP) ou a Cirurgia de Revascularização Miocárdica (CRM). Além disso, a prevenção inclui o controle dos fatores de risco e a adoção de um estilo de vida saudável. As principais complicações, são infarto agudo do miocárdio (IAM), insuficiência cardíaca (IC) e arritmias. O prognóstico da DCI varia dependendo do grau de obstrução das artérias coronárias, da presença de outras condições médicas e da adesão ao tratamento. A detecção precoce e o tratamento adequado da DCI são fundamentais para reduzir o risco de complicações e melhorar a qualidade de vida do paciente.

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Positron emission tomography in ischemic heart disease

Cited by 21 publications

References 64 publications

Hybrid PET/MR imaging for the prediction of left ventricular recovery after percutaneous revascularisation of coronary chronic total occlusions

Hybrid PET/MR imaging for the prediction of left ventricular recovery after percutaneous revascularisation of coronary chronic total occlusions

Application of Nanomaterials in Biomedical Imaging and Cancer Therapy

Doença Cardíaca Isquêmica: aspectos epidemiológicos, fisiopatológicos e manejo terapêutico

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