Positron Emission Tomography in oncology: Present and future of PET and PET/CT

Papathanassiou, Dimitri; Bruna-Muraille, C.; Liehn, Jean‐Claude; Nguyen, Tan Dat; Curé, Hervé

doi:10.1016/j.critrevonc.2008.10.006

Cited by 46 publications

(39 citation statements)

References 110 publications

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“…The charge for their post-RT PET/CT that led to the additional work-up was approximately $6,750. Minimizing FP and equivocal scans and thus increasing the PPV of post-RT FDG-PET/CT response assessment will immensely improve the quality of care for our patients (24, 25). …”

Section: Discussionmentioning

confidence: 99%

Change of Maximum Standardized Uptake Value Slope in Dynamic Triphasic [18F]-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Distinguishes Malignancy From Postradiation Inflammation in Head-and-Neck Squamous Cell Carcinoma: A Prospective Trial

Anderson¹,

Chang²,

Graham³

et al. 2015

International Journal of Radiation Oncology*Biology*Physics

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Purpose/Objectives(s) The positive predictive value (PPV) of post-radiation (RT) 3-month FDG-PET/CT imaging in head and neck squamous cell carcinoma (HNSCC) is limited. Dynamic data acquisition and analysis was evaluated for PPV improvement, utilizing a triphasic PET/CT technique. Methods and Materials We prospectively enrolled HNSCC patients who completed RT, with scheduled 3-month post-RT FDG-PET/CT. Patients underwent our standard whole-body PET/CT scan at 90 minutes, with the addition of head and neck PET/CTs at 60 and 120 minutes. Maximum standardized uptake values (SUVmax) of regions of interest (ROI) were measured at 60, 90, and 120 minutes. SUVmax slope between 60 and 120 minutes, and change of SUVmax slope before and after 90 minutes were calculated. Data were analyzed by primary site and nodal site disease status using the Cox regression model and Wilcoxon Rank Sum Test. Outcomes were based on pathologic and clinical follow-up. Results 84 patients enrolled, with 79 primary and 43 nodal evaluable sites. Twenty-eight sites were interpreted positive or equivocal (18 primary, 8 nodal, 2 distant) on 3-month 90-minute FDG-PET/CT. Median follow-up was 13.3 months. All measured SUV endpoints predicted recurrence. Change of SUVmax slope after 90 minutes more accurately identified non-recurrence in positive or equivocal sites than our current standard of SUVmax ≥ 2.5 (p=0.02). Conclusions The PPV of post-RT FDG-PET/CT may significantly improve using novel second derivative analysis of dynamic triphasic FDG-PET/CT SUVmax slope, accurately distinguishing tumor from inflammation on positive and equivocal scans.

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Section: Discussionmentioning

confidence: 99%

Change of Maximum Standardized Uptake Value Slope in Dynamic Triphasic [18F]-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Distinguishes Malignancy From Postradiation Inflammation in Head-and-Neck Squamous Cell Carcinoma: A Prospective Trial

Anderson¹,

Chang²,

Graham³

et al. 2015

International Journal of Radiation Oncology*Biology*Physics

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“…Not only FDG but also other radiomarkers prove useful in various cancer types [9]. Below, a number of metabolic pathways together with their radiomarkers are mentioned, important for oncology and detectable through PET [10]: 11 C-thymidine, 18 F-thymidine (FLT) – replication of DNA, cellular proliferation, 11 C-methionine (MET), 18 F-ethyl-tyrosine (FET), 18 F-methyl-tyrosine (FMT), 18 F-dihydroxy-phenylalanine (F-DOPA) – protein synthesis, amino acid transport, 18 F-acetate, 11 C-choline, 18 F-choline (FCH) – membrane lipid synthesis, 18 F-misonidazole (FMISO), 64 Cu-copper-ATSM – hypoxia, 18 F-annexin V – apoptosis, 18 F-galacto-RGD – angiogenesis, 18 F-deoxy-arabinofuranosyl-nucleosides (FEAU, FIAU, FMAU) – reporter genes, 18 F-uracil (FU) – tumor therapy control, 18 F-oestradiol (FES) – receptor binding (estrogen), 68 Ga-DOTATOC/DOTANOC – receptor binding (somatostatin). …”

Section: Introductionmentioning

confidence: 99%

Evaluation of FLT-PET/CT usefulness in diagnosis and qualification for surgical treatment of gastric cancer

Staniuk¹,

Zegarski²,

Małkowski³

et al. 2013

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Aim of the studyEvaluation of FLT/PET/ CT usefulness in diagnosis and qualification for surgical treatment of gastric cancer.Material and methodsThe FLT/PET/CT test was carried out in a group of 50 gastric cancer patients. Based on the test result, a decision followed about the therapeutic procedure to be applied. A comparison was made with regards to the consistency of the cancer growth advancement degree evaluation in the initial preoperative FLT/PET/CT test against the evaluation of postoperative degree of cancer advancement in histopathology.ResultsIn the group of 50 diagnosed patients a surgical treatment was used for 37 patients. 21 resections were performed out of which 19 operations were radical In the group of 16 non-resective operations 2 post-laparotomic patients were selected for inductive treatment. In the group of 13 patients who did not undergo any surgery, 10 were directed to palliative care and 3 for inductive treatment. In the group of 50 patients, the applied FLT-PET/CT test confirmed presence of primary tumor in 49 patients. The presence of increased uptake of FLT in the local lymph nodes during the preoperative FLT-PET/CT test was confirmed in 22 cases. In 14 patients with FLT-PET/Ct N(+) with the M(–) feature resection surgery was performed. The increased uptake of FLT in localizing metastases (nodal and non-nodal) FLT-PET/CT (M+) was detected in 22 patients. The presence of nodal metastases in the postoperative histopathology examination (hpN+) was detected in 14 cases. In these cases preoperative FLT-PET/CT test proved the N(+) feature in 11 patients. The result FLT-PET/CT N(–) was truly negative in 2 patients, and false negative in 1 patient. In the group of 7 operated hpN(–) patients, in 3 patients a preoperative result FLT-PET/ CT N(+) (false positive result) was obtained. The consistency (positive) of nodal metastases identification in FLT-PET/CT as compared to post-surgical histopathology examination scored 11/15, which equals 73.3%. In the group of patients in whom resection surgery was performed, 4 false negative results were obtained [hp(N+), FLT-PET/CT (N–)] and 3 false positive results [hp(N–), FLT-PET/CT N(+)].ConclusionsThe initial test results indicate that FLT-PET/CT is an effective method in evaluating the primary tumor and the regional lymph nodes and is useful and beneficial in the diagnosis and further treatment evaluation of gastric cancer. FLT-PET/CT examination facilitates making proper therapeutic decisions – it allows the number of unnecessary laparotomies to be lowered.

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“…Moreover, the introduction of newer tissue-specifi c liver MRI contrast agents has further empowered MRI with improved tissue characterization and small lesion detection capability. These agents show liver-specifi c uptake either by way of the hepatocellular route gadobenate dimeglumine (MultiHance (Bracco Imaging SpA PET imaging using an 18FDG analogue has already established its role in various oncologic applications [32]. The role of 18FDG PET has also been validated in CRC for improved liver metastases detection [16••,33••,34].…”

Section: Role Of Imaging In Colorectal Liver Metastasesmentioning

confidence: 99%

Recent progress in imaging of colorectal cancer liver metastases

Bajpai¹,

Sahani

2009

Curr colorectal cancer rep

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Rapid advances in imaging technologies, such as multidetector CT, MRI, and positron emission tomography (PET) or PET-CT have improved detection, characterization, and staging of colorectal liver metastases. Imaging provides important information in detecting the stage of disease and formulating an appropriate treatment strategy. Response to novel targeted therapies can also be assessed with newer imaging tools. Therefore, knowledge of the established and emerging imaging techniques is essential for selecting an appropriate modality in the management of liver metastases from colorectal cancer.

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Positron Emission Tomography in oncology: Present and future of PET and PET/CT

Cited by 46 publications

References 110 publications

Change of Maximum Standardized Uptake Value Slope in Dynamic Triphasic [18F]-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Distinguishes Malignancy From Postradiation Inflammation in Head-and-Neck Squamous Cell Carcinoma: A Prospective Trial

Change of Maximum Standardized Uptake Value Slope in Dynamic Triphasic [18F]-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Distinguishes Malignancy From Postradiation Inflammation in Head-and-Neck Squamous Cell Carcinoma: A Prospective Trial

Evaluation of FLT-PET/CT usefulness in diagnosis and qualification for surgical treatment of gastric cancer

Recent progress in imaging of colorectal cancer liver metastases

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