Positron Emission Tomography in the Early Follow-up of Advanced Head and Neck Cancer

Goerres, Gerhard W.; Schmid, Daniel T.; Bandhauer, Florian; Huguenin, P; Schulthess, Gustav K. von; Schmid, Stephan; Stoeckli, Sandro J.

doi:10.1001/archotol.130.1.105

Cited by 120 publications

(66 citation statements)

References 17 publications

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“…Therefore, the specificity and false-positive rates should be considered critically in comparison with other studies that report only a single scan in a treated patient. 10,11,[24][25][26][27][28][29][30][31][32][33] In a recent meta-analysis of studies investigating the effectiveness of a single PET scan after RT that included patients with suspected disease recurrence, the sensitivity, specificity, positive predictive value, and negative predictive value were 94%, 82%, 75%, and 95%, respectively. 25 In our experience, false-positive findings in the head and neck remain an issue for PET or PET/CT in the followup care of patients with head and neck cancer.…”

Section: Discussionmentioning

confidence: 99%

The diagnostic and prognostic utility of positron emission tomography/computed tomography‐based follow‐up after radiotherapy for head and neck cancer

Kao

Genden

et al. 2009

Cancer

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Nitroxyl radicals were used as functionalizing agents during the free radical postreactor modification process of polyolefins carried out in the melt. The 4‐hydroxy‐2,2,6,6‐tetramethylpiperidine‐1‐oxyl (HO‐TEMPO) and the 4‐benzoyloxy‐2,2,6,6‐tetramethylpiperidine‐1‐oxyl (BzO‐TEMPO) free radicals were successfully grafted onto a polyethylene‐based material (ethylene‐co‐1‐octene copolymer) by coupling reaction with polymer macroradicals; these last were formed by H‐abstraction through peroxide addition. The macromolecular structure of the functionalized polyolefins was assessed by 1H‐NMR, FTIR spectroscopy, and SEC measurements which were used to evidence the grafting site, to evaluate the grafting level and to highlight the occurrence of chain extension through crosslinking side reactions. Indeed the use of proper model compounds allowed the preparation of accurate FTIR calibration curves for the quantitative determination of the functionalization degree. Besides the high temperature SEC analysis highlighted that this fast and simple coupling reaction between macroradicals and nitroxyl free radicals grants the grafting of functionalities onto the polyolefin backbone by contemporarily preventing the side reactions liable of the structure and MW modification of the pristine polymer. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011

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Section: Discussionmentioning

confidence: 99%

The diagnostic and prognostic utility of positron emission tomography/computed tomography‐based follow‐up after radiotherapy for head and neck cancer

Kao

Genden

et al. 2009

Cancer

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“…37,[40][41][42] However, due to inflammatory uptake, a positive PET/CT result in the head and neck must be correlated with the physical examination and a tissue biopsy may be warranted.…”

Section: Evaluation Of Therapy Responsementioning

confidence: 99%

“…50 In the setting of surveillance, numerous studies have demonstrated that 18 F-FDG-PET/CT has a relatively high sensitivity for detecting recurrent disease at the primary tumor site and regional lymph node metastases. 37,[38][39][40][41][42][43][44][45][49][50][51][52] For patients who underwent PET or PET/CT at least 12 weeks after the completion of all therapy, the reported sensitivity ranged between 90% and 100% for the detection of recurrence. Due to nonspecific inflammatory uptake, the specificity of PET and PET/CT is between 63% and 94%, and a tissue biopsy or shortinterval repeat scanning is warranted.…”

Section: Evaluation Of Recurrence and Surveillancementioning

confidence: 99%

Fluorodeoxyglucose–Positron-Emission Tomography Imaging of Head and Neck Squamous Cell Cancer

Subramaniam

Truong

Peller

et al. 2009

AJNR Am J Neuroradiol

107

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SUMMARY:The hybrid technique of PET/CT has significantly impacted the imaging and management of HNSCC since its introduction in 2001 and has become the technique of choice for imaging of this cancer. Diagnostic FDG-PET/CT is useful for identification of an unknown primary tumor, delineation of extent of primary tumor, detection of regional lymph node involvement even in a normal-sized node, detection of distant metastases and occasional synchronous primary tumor, assessment of therapy response, and long-term surveillance for recurrence and metastases. The role of PET/CT is evolving in radiation therapy planning. Combined diagnostic PET/CT provides the best anatomic and metabolic in vivo information for the comprehensive management of HNSCC.ABBREVIATIONS: CR ϭ complete response; DCT ϭ contrast enhanced diagnostic CT;18 F ϭ fluorine-18; FDG ϭ fluorodeoxyglucose; FDG-PET ϭ fluorodeoxyglucose-positron-emission tomography; FNA ϭ fine-needle aspiration; GTV ϭ gross tumor volume; HNSCC ϭ head and neck squamous cell carcinomas; IMRT ϭ intensity modulated radiation therapy; M ϭ metastasis; N ϭ node; PET ϭ positron-emission tomography; PTV ϭ planning target volume; RD ϭ residual disease; SCC ϭ squamous cell carcinoma; SUV ϭ standard uptake value; SUV max ϭ maximum SUV; T ϭ tumor M ore than 40,000 people are diagnosed with head and neck cancer each year in the United States.1 The overall annual mortality rate for this cancer in the United States is 23%, and the 5-year survival rate is 56%.1-3 More than 80% of early-stage tumors are cured, but nearly one-half of patients have evidence of advanced local disease or lymph node metastases at the time of diagnosis. Surgery and radiation therapy, either alone or in combination with chemotherapy, are used for definitive locoregional treatment of head and neck cancers. For patients with advancedstage and high-risk features, postoperative chemoradiation improves locoregional control and overall survival. 4,5 Cross-sectional imaging with CT and MR imaging is commonly used for tumor staging and may allow detection of subcentimeter lesions. Locoregional lymph node metastases have a major impact on survival. Patients with lymph-node involvement have a worse prognosis (approximately 30%) than patients without lymph node involvement (Ͼ50% 5-year survival). 6,7 PET using the radiotracer 18 F FDG is widely used to evaluate patients with HNSCC. The hybrid technique, PET/CT, provides anatomic and functional information and can be performed as PET and DCT with intravenous contrast-enhancement (PET/ DCT) or PET and noncontrast CT (PET/CT) for attenuation correction and anatomic localization. PET/CT is useful for identification of an unknown primary tumor, delineation of the extent of regional lymph node involvement, detection of distant metastases and occasional synchronous primary tumor, radiation-therapy planning, assessing therapy response, and long-term surveillance for recurrence and metastases.PET/CT Protocols PET/CT imaging was developed to improve PET imaging by expediting attenuation c...

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“…Elle peut être utilisée pour le diagnostic, le bilan initial [5,6], la surveillance après le traitement [7] et la mise en évidence des récidives [8].…”

Section: Indications De La Tep-fdg Et De La Tep-tdmunclassified

Tomographie par émission de positrons dans la prise en charge des carcinomes épidermoïdes des VADS

Kerrary

Bertrand

Ernenwein

2010

Med Buccale Chir Buccale

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Mots clés : TEP-TDM / carcinomes des voies aérodi-gestives supérieuresRésumé -Le carcinome épidermoïde représente la forme la plus fréquente des cancers des voies aérodi-gestives supérieures (VADS). L'anatomie complexe de la région cervicofaciale rend son exploration assez difficile. Si l'imagerie conventionnelle permet d'obtenir des informations topographiques intéressantes, la médecine nucléaire avec la tomographie par émission de positrons (TEP) au [ 18 F]-fluoro-2-désoxy-Dglucose ( 18 F-FDG) constitue un progrès pour le bilan d'extension dans les aires ganglionnaires et la dé-tection de néoplasies synchrones. Sa place est appelée à devenir primordiale pour la recherche de lésions résiduelles et la détection précoce des récidives. L'évaluation de la réponse à la chimiothérapie et l'optimisation de la radiothérapie (champs et dosimétrie) constituent également des applications prometteuses car la technique de la TEP est en évolution constante. Key words: PET-CT / head and neck carcinomasAbstract -Positron emission tomography in head and neck squamous cell carcinomas. Squamous cell carcinoma is the most frequent of head and neck cancers. The complex anatomy of head and neck areas makes more difficult its exploration. If the conventional imaging provides interesting topographic informations, the contribution of the nuclear medicine through positron emission tomography (PET) with [ 18 F]-fluoro-2-deoxy-D-glucose is efficient for staging lymph nodes and detection of synchronous neoplasias. Besides, its place is also known to be essential for detecting residual lesions and early detection of recurrences. Assessment of tumor response to treatment with chemotherapy and optimization fields and dosimetry in radiotherapy are also proving to be full of promising applications especially because the technique by PET is in constant evolution. Généralités et épidémiologie

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Positron Emission Tomography in the Early Follow-up of Advanced Head and Neck Cancer

Cited by 120 publications

References 17 publications

The diagnostic and prognostic utility of positron emission tomography/computed tomography‐based follow‐up after radiotherapy for head and neck cancer

The diagnostic and prognostic utility of positron emission tomography/computed tomography‐based follow‐up after radiotherapy for head and neck cancer

Fluorodeoxyglucose–Positron-Emission Tomography Imaging of Head and Neck Squamous Cell Cancer

Tomographie par émission de positrons dans la prise en charge des carcinomes épidermoïdes des VADS

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