Positron emission tomography is superior to computed tomography for metastatic detection in melanoma patients

Swetter, Susan M.; Carroll, Lisa A.; Johnson, Denise; Segall, George M.

doi:10.1007/bf02574480

Cited by 122 publications

(48 citation statements)

References 21 publications

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“…15). Thus, PET/CT is playing an increasing role in the management of these patients, and has improved diagnostic accuracy for both detection of disease and treatment monitoring when compared with both conventional imaging modalities and PET alone [63][64][65]. Lymphoma and Melanoma summary below:…”

Section: Lymphoma and Melanomamentioning

confidence: 99%

Indications for PET/CT in the Head and Neck

Agarwal

Branstetter

Johnson

2008

Otolaryngologic Clinics of North America

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Head and neck cancer accounts for approximately 3% to 5% of all new cancer diagnoses in the United States with 40,000 new cases diagnosed each year [1]. These figures encompass cancers arising from the lip, oral cavity, nasal cavity, paranasal sinuses, pharynx, and larynx, of which the vast majority (90% to 95%) are squamous cell carcinomas arising from mucosal linings of the upper aerodigestive tract. Other, rare cancers that may involve the head and neck include salivary tumors, thyroid cancers, lymphoma, and melanoma.Early diagnosis and accurate staging are essential for treatment planning and can strongly influence prognosis. Likewise, early identification of tumor recurrence can often be treated with additional surgery or re-irradiation. A combination of history, physical exam, endoscopy, and tissue sampling has historically been the mainstay of diagnosis and staging. The use of crosssectional imaging (CT and MRI) has greatly improved staging and monitoring for disease recurrence. Small metastases and/or early recurrent disease, however, can still be missed [2].Functional imaging with 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) can be used to fill these gaps and improve characterization of both primary tumors and metastatic disease. PET has been shown to be effective in the diagnosis of many different types of cancer, including head and neck squamous cell carcinoma (HNSCC) [3]; however, the poor spatial resolution of PET and the lack of anatomic landmarks can make exact localization of disease difficult. In addition, normal

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Section: Lymphoma and Melanomamentioning

confidence: 99%

Indications for PET/CT in the Head and Neck

Agarwal

Branstetter

Johnson

2008

Otolaryngologic Clinics of North America

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“…6-20 Some studies suggest that FDG-PET may be more sensitive and specific than conventional diagnostic tests for detecting this disease. 13,14,17,20 However, these studies have some important limitations, which include a lack of pathologic confirmation of suspected sites of metastatic disease and a relatively short clinical follow-up. In addition, most studies have determined specificity and sensitivity on the basis of a patient-by-patient analysis instead of a lesion-by-lesion analysis.…”

mentioning

confidence: 99%

A Prospective Analysis of Positron Emission Tomography and Conventional Imaging for Detection of Stage IV Metastatic Melanoma in Patients Undergoing Metastasectomy

et al. 2004

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“…[7][8][9][10][11][12] Technologies such as MRI, MR spectroscopy, among others can provide functional and physiological information about skin lesions as well as information about size, depth and location. [13][14][15][16][17][18] While optical coherence tomography and other optical techniques, including elastography, show promise given their ability to provide high-resolution skin imaging and flow data, [19][20][21] they are not readily available in imaging or dermatology departments. Optical imaging can only penetrate to the level of the dermis and not to deeper structures, which is a major limitation in staging, evaluation of the extent of disease and lesion characterization.…”

Section: Introductionmentioning

confidence: 99%

Quantified ultrasound elastography in the assessment of cutaneous carcinoma

Dasgeb¹,

Morris

Mehregan³

et al. 2015

BJR

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Objective: To evaluate the feasibility of high-frequency ultrasound and ultrasound elastography (USE) in discriminating benign from malignant skin lesions in a prospective cohort study and to introduce the use of a "strain ratio" for evaluation of skin lesions. Methods: A commercial ultrasound system with a 14-MHz transducer was used to visualize skin lesions requiring biopsy on clinical evaluation. Anatomic ultrasound and USE imaging of the skin lesions was performed using 2-to 4-mm gel stand-off pads. A region of interest was manually selected over the area of each lesion with the lowest strain. The concept of a strain ratio of the compressibility of the normal skin at the corresponding layer to that of the least compressible region of a lesion in question was created and applied. This ratio was subsequently correlated with blind histopathological evaluation for malignancy. Results: 55 patients were included in the study with a total of 67 lesions evaluated. 29 lesions were malignant and 38 benign. All malignant lesions had strain ratios $3.9. All benign lesions had strain ratios #3.0. A diagnostic value between 3.0 and 3.9 would result in 100% sensitivity and specificity in the characterization of these lesions as malignant.Conclusion: This pilot study demonstrated that USE plus strain ratio appears to be a promising modality in providing diagnostic determination between cancerous and benign primary solitary skin lesions prior to biopsy. Advances in knowledge: This is the first reported study applying an original mathematical elastographic ratio, or strain ratio, to evaluate primary solitary skin lesions.

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Positron emission tomography is superior to computed tomography for metastatic detection in melanoma patients

Cited by 122 publications

References 21 publications

Indications for PET/CT in the Head and Neck

Indications for PET/CT in the Head and Neck

A Prospective Analysis of Positron Emission Tomography and Conventional Imaging for Detection of Stage IV Metastatic Melanoma in Patients Undergoing Metastasectomy

Quantified ultrasound elastography in the assessment of cutaneous carcinoma

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