Positron emission tomography (PET) guided glioblastoma targeting by a fullerene-based nanoplatform with fast renal clearance

Peng, Yayun; Yang, Dongzhi; Lu, Weifei; Hu, Xiongwei; Hong, Hao; Cai, Ting

doi:10.1016/j.actbio.2017.08.011

Cited by 23 publications

(20 citation statements)

References 55 publications

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“…The ζ-potential of C 60 -NOTA and C 60 -Cu(NOTA) were also investigated to determine the surface charge on the conjugate, which can affect the biodistribution of the material [49]. The ζ-potential of C 60 -NOTA and C 60 -Cu(NOTA) were −22.5 mV and −11.4 mV, respectively, which agrees well with ζ-potential measurements of C 60 -serinol and other water soluble C 60 materials [39,47,50]. The C60-NOTA conjugate was then chelated with nonradioactive Cu 2+ to demonstrate the chelating ability of NOTA while appended to the C60 cage.…”

Section: Synthesis and Characterization Of C 60 -Nota Conjugatesupporting

confidence: 69%

“…While the above examples showed studies that observed long in vivo residence times for fullerene derivatives, one study reported a fast-clearing amino-PEGylated C 60 derivative [39]. The authors analyzed this material that had a similar diameter and surface charge as our construct, which was also radiolabeled with [ 64 Cu]Cu(NOTA).…”

Section: Discussionmentioning

confidence: 99%

“…Overall, these similar results to our work show that masking the hydrophobic surface of C 60 with different hydrophilic groups can effectively lead to fast renal clearance. Furthermore, this group examined the toxicity of their material and found that the compound was not cytotoxic at 100 µg/mL exposure [39]. We have previously shown that C 60 -serinol is likewise non-cytotoxic at the same concentration [34].…”

Section: Discussionmentioning

confidence: 99%

“…Matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS) was performed using an Autoflex MALDI An important aspect of designing drug delivery platforms is the study of the biodistribution and excretion profile of the compound. Thus far, the biodistribution profiles of C 60 reported in the literature, including C 60 -serinol, are discordant [38][39][40][41]. This work aims to reevaluate the in vivo behavior of this nanomaterial non-invasively, using the imaging technique positron emission tomography (PET).…”

Section: Synthesis and Characterization Of C60-cu(nota)mentioning

confidence: 99%

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Evaluation of the Biodistribution of Serinolamide-Derivatized C60 Fullerene

et al. 2020

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Carbon nanoparticles have consistently been of great interest in medicine. However, there are currently no clinical materials based on carbon nanoparticles, due to inconsistent biodistribution and excretion data. In this work, we have synthesized a novel C60 derivative with a metal chelating agent (1,4,7-Triazacyclononane-1,4,7-triacetic acid; NOTA) covalently bound to the C60 cage and radiolabeled with copper-64 (t1/2 = 12.7 h). Biodistribution of the material was assessed in vivo using positron emission tomography (PET). Bingel-Hirsch chemistry was employed to functionalize the fullerene cage with highly water-soluble serinolamide groups allowing this new C60 conjugate to clear quickly from mice almost exclusively through the kidneys. Comparing the present results to the larger context of reports of biocompatible fullerene derivatives, this work offers an important evaluation of the in vivo biodistribution, using experimental evidence to establish functionalization guidelines for future C60-based biomedical platforms.

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Section: Synthesis and Characterization Of C 60 -Nota Conjugatesupporting

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Synthesis and Characterization Of C60-cu(nota)mentioning

confidence: 99%

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Evaluation of the Biodistribution of Serinolamide-Derivatized C60 Fullerene

et al. 2020

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“…pathways of FTNPs. According to our statistics, renal excretion is the main way of most of FTNPs cleared from the body, such as gold NPs, [239][240][241][242] UCNPs, [243][244][245] and FCNMs [227,[246][247][248][249] ( Table 1). Only a little FNPs are eliminated through hepatic, such as Ag 2 S QDs, [250] CdSe 0.25 Te 0.75 /CdS, [251] and so on.…”

Section: Biodistribution Clearance Pathways and Biosafety Of Fnpsmentioning

confidence: 99%

Tumor Targeting Strategies of Smart Fluorescent Nanoparticles and Their Applications in Cancer Diagnosis and Treatment

et al. 2019

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River Scholar of China and the Foreign Academicians of the Russian Academy of Engineering and Russian Academy of Science. Her research interests mainly focus on bioeffects and safety evaluation of nanomaterials and environmental pollution analysis and control. Rui L. Reis obtained his Ph.D. and D.Sc. in polymer engineering-biomaterials & tissue engineering from the University of Minho, Portugal. He is vice president for Research and Innovation of UMinho and the director of the 3B's Research Group and ICVS/3B's Associate Laboratory. He is a full professor of Tissue Engineering, Regenerative Medicine and Stem Cells at UMinho and honorary professor in four different Asian Universities. His main area of research is the development of biomaterials from natural origin polymers, and using those in combination with different stem cells for several strategies for tissue engineering and regenerative medicine, applied to distinct human tissues.

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Transforming Passive into Active: Multimodal Pheophytin‐Based Carbon Dots Customize Protein Corona to Target Metastatic Breast Cancer

Peng

Cong

Lei

et al. 2022

Adv Healthcare Materials

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Formation of protein corona on nanomaterials surface in vivo isusually considered as an unpredictable event for a predefined targeted delivery system for malignant cancers. In most situations, these protein coronas substantially change targeting efficiency or even cause adverse reactions which both hinder the clinical translation of the cargo-delivery systems. Active customization of protein corona onto nanomaterials surfaces can benefit their biomedical performances and open up new opportunities in construction of targeted delivery systems. Herein, lipid-PEG/pheophytin carbon dots (LPCDs) are prepared from natural chlorophyll and integrate seamlessly with positron emission tomography imaging, near-infrared fluorescence imaging, and photodynamic therapy capacity. In vitro measurements demonstrate that the LPCDs can actively absorb apolipoproteins into the protein corona to enhance their uptakes in breast cancer cells. In vivo studies confirm that LPCDs can give accurate delineation of metastatic breast cancer foci from surrounding normal tissues with multimodal biomedical functions. The feasibility of using LPCDs as a multimodal imaging and cancer-targeting nanoplatform may provide impetus for developing precise yet facile protein corona-targeted delivery systems for future clinical practice.

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Positron emission tomography (PET) guided glioblastoma targeting by a fullerene-based nanoplatform with fast renal clearance

Cited by 23 publications

References 55 publications

Evaluation of the Biodistribution of Serinolamide-Derivatized C60 Fullerene

Evaluation of the Biodistribution of Serinolamide-Derivatized C60 Fullerene

Tumor Targeting Strategies of Smart Fluorescent Nanoparticles and Their Applications in Cancer Diagnosis and Treatment

Transforming Passive into Active: Multimodal Pheophytin‐Based Carbon Dots Customize Protein Corona to Target Metastatic Breast Cancer

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