Positron emission tomography (PET) with 18F-fluorodeoxyglucose (18F-FDG) for the staging of low-grade non-Hodgkin’s lymphoma (NHL)

Jérusalem, Guy; Béguin, Yves; Najjar, Fadi; Hustinx, Roland; Fassotte, Marie-France; Rigo, Pierre; Fillet, Georges

doi:10.1023/a:1011169332265

Cited by 257 publications

(134 citation statements)

References 26 publications

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“…No abnormal tracer uptake was seen in the patient with low-grade gastric NHL of the MALT type, they found more tumor extension compared to endoscopy but they didn't report the CT finding. Jerusalem et al reported that PET plus a bone marrow biopsy compared to conventional staging procedures (also including a bone marrow biopsy) observed the same stage in 37 patients, a higher stage by PET in two patients [12], in our study PET detected bone marrow disease in 16 patients could not be catched by CT scan alone, and this was confirmed by bone marrow biopsy results, taking into consideration that the Jerusalem series was for patients with low grade lesions. Diffuse high FDG uptake of the bone marrow can occur due to the reactive changes of chemotherapy or the use of Colony-stimulating Growth factors (CSGF), in our study we insisted that the patient do not receive chemotherapy or CSGF at least two weeks prior to their PET scan.…”

Section: Discussionsupporting

confidence: 85%

Role of 18F-FDG PET versus CT Scan in Evaluation of Extra-Nodal Lymphoma

El-Haddad¹,

Omar²,

Mahdy³

2015

J Nucl Med Radiat Ther

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Purpose: To compare findings in fluorine 18-fluorodeoxyglucose (FDG) positron emission tomography (PET) and computed tomography (CT) in patients with extra-nodal lymphoma by using a combined PET/CT scanner. Methods and Materials:Between 2011 and April 2013, seventy seven patients with confirmed pathology of Hodgkin (32 patients) and Non Hodgkin lymphoma (45 patients) with extranodal involvement diagnosed at Nasser Institute Cancer Center (NICC), ministry of health, Cairo, Egypt. After collection of the two reports separately, combined reading was allowed afterwards, and the differences were recorded for our study.Results: PET-CT is very effective in detection of lesions in the bone and bone marrow, few patients may have CT finding without corresponding FDG uptake, CT without PET may be very effective in detecting recurrences in soft tissue, renal and GIT extrannodal lymphoma. Conclusion:PET scan is more sensitive than the CT used alone, and the combination PET-CT can be considered the standard of care for detection of extranodal lymphomas excluding soft tissue, renal and GI lymphomas.

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Section: Discussionsupporting

confidence: 85%

Role of 18F-FDG PET versus CT Scan in Evaluation of Extra-Nodal Lymphoma

El-Haddad¹,

Omar²,

Mahdy³

2015

J Nucl Med Radiat Ther

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“…sification, indolent lymphomas frequently lack FDG avidity. 19 However, their incidence might increase in the future due to improved patient survival and given the higher age of transplant recipients. 20 Secondly, PET scan is not the preferred examination in case of suspicion of central nervous system localization.…”

Section: Ptldmentioning

confidence: 99%

The accuracy of positron emission tomography in the detection of posttransplant lymphoproliferative disorder

et al. 2012

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ABSTRACTconventional CT scan less appropriate for adequate staging and less suitable for image-guided biopsy.Recently, 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET) combined with CT has emerged as the most sensitive and specific imaging modality for diagnosis and staging of both Hodgkin's and different subtypes of aggressive non-Hodgkin's lymphoma. 4 The role of FDG-PET scan in PTLD, however, has not yet been established.Our aim was to evaluate the accuracy and clinical performance of FDG-PET scan in the diagnosis of PTLD in a large cohort of transplant recipients.

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“…Combined FDG-PET/CT has also been shown to be more accurate than PET alone or CT alone in the staging, restaging of patients with indolent lymphomas [13,15,16]. To our knowledge, to date, no study has investigated the value of FDG-PET specifically in the patient population of WM.…”

Section: Introductionmentioning

confidence: 99%

The role of ¹⁸F‐FDG PET/CT imaging in Waldenstrom macroglobulinemia

et al. 2011

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Disease assessment in WM is dependent on the quantification of the IgM monoclonal protein and percent involvement of the bone marrow. There is a need for imaging studies that objectively measure tumor load in these patients. In this study, we sought to examine the role of combined FDG-PET/CT imaging in the detection of tumor load and in the assessment of response to therapy. Thirty-five patients were enrolled on a prospective study using bortezomib and rituximab therapy and were included in this study because they completed a pre-and post-treatment FDG-PET/CT imaging at one facility (12 newly diagnosed and 23 relapsed/refractory). The use of combined FDG-PET/CT imaging showed positive findings in 83% of patients with WM, unlike prior studies using conventional imaging that indicate that only 20% of patients have lymphadenopathy or hepatosplenomegaly. Moreover, 43% of patients had abnormal bone marrow uptake on FDG-PET imaging that can potentially help in the assessment of their tumor load, especially with heterogenous sampling of the bone marrow. There was no statistical correlation between EORTC response criteria for FDG-PET/CT and response by monoclonal protein. This is the first study to examine the role of FDG-PET/CT imaging in WM. Future studies should examine the role of FDG-PET/CT in conjunction with monoclonal protein response in the assessment of progression-free survival in patients with WM. Am. J. Hematol. 86:567-572, 2011. V

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Positron emission tomography (PET) with 18F-fluorodeoxyglucose (18F-FDG) for the staging of low-grade non-Hodgkin’s lymphoma (NHL)

Cited by 257 publications

References 26 publications

Role of 18F-FDG PET versus CT Scan in Evaluation of Extra-Nodal Lymphoma

Role of 18F-FDG PET versus CT Scan in Evaluation of Extra-Nodal Lymphoma

The accuracy of positron emission tomography in the detection of posttransplant lymphoproliferative disorder

The role of ¹⁸F‐FDG PET/CT imaging in Waldenstrom macroglobulinemia

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Positron emission tomography (PET) with 18F-fluorodeoxyglucose (18F-FDG) for the staging of low-grade non-Hodgkin’s lymphoma (NHL)

Cited by 257 publications

References 26 publications

Role of 18F-FDG PET versus CT Scan in Evaluation of Extra-Nodal Lymphoma

Role of 18F-FDG PET versus CT Scan in Evaluation of Extra-Nodal Lymphoma

The accuracy of positron emission tomography in the detection of posttransplant lymphoproliferative disorder

The role of 18F‐FDG PET/CT imaging in Waldenstrom macroglobulinemia

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The role of ¹⁸F‐FDG PET/CT imaging in Waldenstrom macroglobulinemia