Positron emission tomography with [¹⁸F]flutemetamol and [¹¹C]PiB for in vivo detection of cerebral cortical amyloid in normal pressure hydrocephalus patients

Abstract

[18F]Flutemetamol detects brain amyloid-β in vivo with moderate to high sensitivity and high specificity. This agent, therefore, represents a valuable new tool to study and verify the presence of amyloid-β pathology, both in patients with possible NPH and among the wider population.

Post-mortem histopathology underlying β-amyloid PET imaging following flutemetamol F 18 injection

“…β-amyloid PET imaging studies with neuropathology validation in post-mortem brains [2, 9–11, 27, 28, 32, 33, 45, 53, 62] or biopsy brain tissues [37, 50, 51, 67] are usually limited by small numbers of subjects and could be biased by variable time between PET acquisition and autopsy or biopsy. However, our study of 106 subjects is a relatively large cohort and the influence of variable PET to autopsy interval was not a significant factor [49].…”

Regional Differences in Amyloid Deposition between 11C-Pib PET Positive Patients with and without Elevated Striatal Amyloid Uptake

“…As not only the striatum, but also the orbitofrontal cortex plays a major role in decision making [33] may demonstrate the relationship between striatum and basal frontal cortices. Other regions showing a positive correlation in PiB uptake with the striatal area were adjacent regions located mostly in the temporal cortex (BA 21,38,20,39), as well as in other frontal areas (BA 47,8). For all of these regions except BA 38, Di Martino et al found positive functional connectivity relationships with striatal or dorsal caudate seed regions [34].…”

“…The National Institutes of Aging and the Alzheimer's Association have recommended their use as clinical and research criteria for the diagnosis of AD [3,4]. 11 C-PiB, the first and most commonly used PET amyloid tracer, permits robust differentiation of AD patients and healthy controls, while regional PiB binding corresponds well with the findings of histopathological assays [5][6][7][8][9]. β-Amyloid plaques and tangles probably precede the onset of clinical symptoms by many years and show a typical distribution pattern in the cerebral grey matter during the progress of the disease [10][11][12].…”

Asymmetric Oligothiophenes : Chemical Evolution of Multimodal Amyloid Ligands

“…A method, now in use, has been developed where PET is used as a noninvasive diagnostic tool for the visualization of Aβ-deposits in the brain and a wide range of PET-ligands have been developed for the diagnosis of AD, one of the most common is Pittsburgh compound B, (PiB). [51,[95][96][97][98] Our interest in PET-ligands started when it was shown that PiB, (See figure 10), also could visualize amyloid deposits in the heart [99], although there are no generally available PET-ligands for imaging of amyloid deposits in heart, pancreas, liver and kidney. LCOs however, have shown specificity for different types of protein aggregates such as aggregates in prion diseases, AD and systemic amyloidosis [24,54,100,101].…”