Positron range in combination with point-spread-function correction: an evaluation of different implementations for [124I]-PET imaging

Kertész, Hunor; Conti, Maurizio; Panin, Vladimir; Cabello, Jorge; Bharkhada, Deepak; Beyer, Thomas; Papp, László; Jentzen, Walter; Cal-González, Jacobo; Herraiz, Joaquín L.; López-Montes, Alejandro; Rausch, Ivo

doi:10.1186/s40658-022-00482-y

Cited by 6 publications

(5 citation statements)

References 27 publications

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“…Of note, in this study we evaluated only standard reconstruction settings including PSF correction. The effect of PSF on image quality is well described [ 31 – 33 ] in the literature. PSF correction is known to reduce background noise and to enhance contrast [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Image quality assessment along the one metre axial field-of-view of the total-body Biograph Vision Quadra PET/CT system for 18F-FDG

et al. 2022

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Aim Recently, total-body PET/CT systems with an extended axial field-of-view (aFOV) became commercially available which allow acquiring physiologic information of multiple organs simultaneously. However, the nominal aFOV may clinically not be used effectively due to the inherently reduced sensitivity at the distal ends of the aFOV. The aim of this study was to assess the extent of the useful aFOV of the Biograph Vision Quadra PET/CT system. Methods A NEMA image quality (IQ) phantom mimicking a standard [18F]FDG examination was used. Image contrast and noise were assessed across the 106 cm aFOV of the Biograph Vision Quadra PET/CT system (Siemens Healthineers). Phantom acquisitions were performed at different axial positions. PET data were rebinned to simulate different acquisition times for a standard injected activity and reconstructed using different filter settings to evaluate the noise and images along the axial direction. Results Image noise and contrast were stable within the central 80 cm of the aFOV. Outside this central area, image contrast variability as well as image noise increased. This degradation of IQ was in particular evident for short acquisition times of less than 30 s. At 10 min acquisition time and in the absence of post-reconstruction filtering, the useful aFOV was 100 cm. For a 2 min acquisition time, a useful aFOV with image noise below 15% was only achievable using Gaussian filtering with axial extents of between 83 and 103 cm when going from 2 to 6 mm full-width-half-maximum, respectively. Conclusion Image noise increases substantially towards the ends of the aFOV. However, good IQ in compliance with generally accepted benchmarks is achievable for an aFOV of > 90 cm. When accepting higher image noise or using dedicated protocol settings such as stronger filtering a useful aFOV of around 1 m can be achieved for a 2 min acquisition time.

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Section: Discussionmentioning

confidence: 99%

Image quality assessment along the one metre axial field-of-view of the total-body Biograph Vision Quadra PET/CT system for 18F-FDG

et al. 2022

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“…Although iodine-124 has a similar positron range (Rmean = 4.4 mm) to gallium-68 (~4 mm), it is greater than fluorine-18 (0.6 mm) or Zr-89 (1.3 mm) [45], which can lead to degradation of high-resolution PET images. However, high-resolution PET data using iodine-124 is possible using prompt gamma correction and point spread function reconstruction methods and can be further improved with correction for the positron range [46].…”

Section: Discussionmentioning

confidence: 99%

Clinical Confirmation of Pan-Amyloid Reactivity of Radioiodinated Peptide 124I-p5+14 (AT-01) in Patients with Diverse Types of Systemic Amyloidosis Demonstrated by PET/CT Imaging

et al. 2023

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There are at least 20 distinct types of systemic amyloidosis, all of which result in the organ-compromising accumulation of extracellular amyloid deposits. Amyloidosis is challenging to diagnose due to the heterogeneity of the clinical presentation, yet early detection is critical for favorable patient outcomes. The ability to non-invasively and quantitatively detect amyloid throughout the body, even in at-risk populations, before clinical manifestation would be invaluable. To this end, a pan-amyloid-reactive peptide, p5+14, has been developed that is capable of binding all types of amyloid. Herein, we demonstrate the ex vivo pan-amyloid reactivity of p5+14 by using peptide histochemistry on animal and human tissue sections containing various types of amyloid. Furthermore, we present clinical evidence of pan-amyloid binding using iodine-124-labeled p5+14 in a cohort of patients with eight (n = 8) different types of systemic amyloidosis. These patients underwent PET/CT imaging as part of the first-in-human Phase 1/2 clinical trial evaluating this radiotracer (NCT03678259). The uptake of 124I-p5+14 was observed in abdominothoracic organs in patients with all types of amyloidosis evaluated and was consistent with the disease distribution described in the medical record and literature reports. On the other hand, the distribution in healthy subjects was consistent with radiotracer catabolism and clearance. The early and accurate diagnosis of amyloidosis remains challenging. These data support the utility of 124I-p5+14 for the diagnosis of varied types of systemic amyloidosis by PET/CT imaging.

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“…Furthermore, positron range is dependent on the tissue and cannot be generalized for every patient. In cases where a high-range isotope is used, such as 124 I, 82 Rb, or 68 Ga, we recommend implementing a specific positron range correction kernel, as proposed in previous works [20,41,46].…”

Section: Discussionmentioning

confidence: 99%

“…Point Spread Function (PSF) models, implemented in the SRM using image or projection blurring kernels, are commonly used to achieve resolution modeling [19][20][21]. Blurring into the projection space can be applied to sinogram data, or to line of response (LOR) data, and it is considered a more fundamental approach, although it is also computationally more demanding.…”

Section: Introductionmentioning

confidence: 99%

Reconstruction of multi-animal PET acquisitions with anisotropically variant PSF

Arias-Valcayo,

Galve,

Herraiz

et al. 2023

Biomed. Phys. Eng. Express

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Among other factors such as random, attenuation and scatter corrections, uniform spatial resolution is key to performing accurate quantitative studies in Positron emission tomography (PET). Particularly in preclinical PET studies involving simultaneous acquisition of multiple animals, the degradation of image resolution due to the depth of interaction (DOI) effect far from the center of the Field of View (FOV) becomes a significant concern. In this work, we incorporated a spatially-variant resolution model into a real time iterative reconstruction code to obtain accurate images of multi-animal acquisition. We estimated the spatially variant point spread function (SV-PSF) across the FOV using measurements and Monte Carlo (MC) simulations. The SV-PSF obtained was implemented in a GPU-based Ordered subset expectation maximization (OSEM) reconstruction code, which includes scatter, attenuation and random corrections. The method was evaluated with acquisitions from two preclinical PET/CT scanners of the SEDECAL Argus family: a Derenzo phantom placed 2 cm off center in the 4R-SuperArgus, and a multi-animal study with 4 mice in the 6R-SuperArgus. The SV-PSF reconstructions showed uniform spatial resolution without significant increase in reconstruction time, with superior image quality compared to the uniform PSF model.

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Positron range in combination with point-spread-function correction: an evaluation of different implementations for [124I]-PET imaging

Cited by 6 publications

References 27 publications

Image quality assessment along the one metre axial field-of-view of the total-body Biograph Vision Quadra PET/CT system for 18F-FDG

Image quality assessment along the one metre axial field-of-view of the total-body Biograph Vision Quadra PET/CT system for 18F-FDG

Clinical Confirmation of Pan-Amyloid Reactivity of Radioiodinated Peptide 124I-p5+14 (AT-01) in Patients with Diverse Types of Systemic Amyloidosis Demonstrated by PET/CT Imaging

Reconstruction of multi-animal PET acquisitions with anisotropically variant PSF

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