Positron range in PET imaging: non-conventional isotopes

Jødal, Lars; Loirec, C. Le; Champion, C.

doi:10.1088/0031-9155/59/23/7419

Cited by 65 publications

(47 citation statements)

References 31 publications

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“…Furthermore, the β + energy of 52m Mn (2633 keV) is higher than that of 51 Mn. This results in a mean ß + range of 5.3 mm in tissue and, thus, in a correspondingly lower resolution of PET images. Additionally, 52m Mn decays partially via internal conversion to its ground state 52g Mn, leading to an increasing contamination with the longer‐living 52g Mn over time.…”

Section: Relevant Pet Radionuclides Of Manganese For Medical Imagingmentioning

confidence: 99%

Manganese in PET imaging: Opportunities and challenges

Brandt

Cardinale

Rausch

et al. 2019

Labelled Comp Radiopharmac

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Several radionuclides of the transition metal manganese are known and accessible. Three of them, 51Mn, 52mMn, and 52gMn, are positron emitters that are potentially interesting for positron emission tomography (PET) applications and, thus, have caught the interest of the radiochemical/radiopharmaceutical and nuclear medicine communities. This mini‐review provides an overview of the production routes and physical properties of these radionuclides. For medical imaging, the focus is on the longer‐living 52gMn and its application for the radiolabelling of molecules and other entities exhibiting long biological half‐lives, the imaging of manganese‐dependent biological processes, and the development of bimodal PET/magnetic resonance imaging (MRI) probes in combination with paramagnetic natMn as a contrast agent.

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Section: Relevant Pet Radionuclides Of Manganese For Medical Imagingmentioning

confidence: 99%

Manganese in PET imaging: Opportunities and challenges

Brandt

Cardinale

Rausch

et al. 2019

Labelled Comp Radiopharmac

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“…86 Y (14.7 h), 89 Zr (78.4 h), 64 Cu (12.7 h), etc. in recent years [3][4][5]. Among other, 64 Cu is one of the most promising isotopes for the PET usage because it possesses the smallest average energy of positrons, and its half-life allows delivery to local clinics [6,7].…”

Section: Introductionmentioning

confidence: 99%

“…The target amides 4 were finally obtained by gentle base treatment of the salts 4*HCl (SI p. [2][3][4][5][6]. It was found that choice of the base is crucial to obtain the amides 4: using of strong base like alkali lead to de-acylation instead of formation of target amino-amides.…”

Section: Introductionmentioning

confidence: 99%

Supramolecular Organogels Based on N-Benzyl, N’-Acylbispidinols

Медведько

Dalinger

Nuriev

et al. 2018

Preprint

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The acylation of unsymmetrical N-benzylbispidinols in aromatic solvents without external base led to formation of supramolecular gels, which possess different thickness and stability depending on the substituents in para-positions of benzylic group and nature of acylating agent as well as on the nature of the solvent used. Structural features of the native gels as well as of their dried forms were studied by complementary techniques including FT IR-and ATR-spectroscopy, AFM, TEM, SEM, SAXS. Structures of the key crystalline compounds were established by X-ray diffraction. Analysis of obtained data allowed speculating on the crucial structural and condition factors that governed the gel formation. The most important factors were: (i) absence of base, either external or internal; (ii) presence of HCl; (iii) presence of carbonyl and hydroxyl groups to allow hydrogen bonding; (iv) presence of two (hetero)aromatic rings at both sides of the molecule. The hydrogen bonding involving amide carbonyl, hydroxyl at 9 th position and, very probably, ammonium N-H+ and Cl-anion appear to be responsible for the formation of infinite molecular chains required for the first step of gel formation. Subsequent lateral cooperation of molecular chains into fibers occured, presumably, due to the aromatic pi-pi-stacking interactions. sc-CO2 drying of the gels gave rise to aerogels morphology different from that of air dried samples. requires use of poly/multifunctional chelating agents that should form covalent bonds with various biomolecules/vectors possessing high specificity and selectivity towards certain targets [5], [8][9][10][11]. 3,7-Diazabicyclo[3.3.1]nonanes (hereafter called bispidines) are one of the privileged scaffolds in medicinal chemistry [12] due to the number of advantages, e.g. (i) high basicity and solubility in water and/or organic solvents [13,14]; (ii) ability to diverse functionalization including chiral derivatives [15][16][17][18][19][20]; (iii) deeply studied conformational features which allow application of some rigid conformation [21][22][23]. Our recent works have shown potential of using the bispidine scaffolds for design of inhibitors of serine proteases [24,25]. At the same time, bispidines are well-known ligands with high affinity to Cu(II) and some other bivalent metals [26][27][28][29]. Therefore, we focus on creating new potent ligands for 64 Cu PET based on number of unsymmetrically substituted bispidine-9-ols. During our work with ligands for serine proteases it was necessary to find a way to insert bulky groups into pockets of the active site [24,25]. The acylation reaction is one of the obvious ways to functionalize the secondary amine group in N-benzylbispidinols; the resulting N-benzyl, N'-acylbispidinols allow subsequent transformations like reduction of amide group or removal of the protecting benzylic group followed by diverse functionalization of the formed secondary amine. In the course of our work we have discovered an interesting phenomenon, namely, formation of gels during the acylatio...

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“…First, when compared to 90 Y ( t 1/2 ~ 64.1 h), 86 Y possesses a shorter half-life (14.7 h), which can preclude imaging studies at later time points. In addition, 86 Y emits a relatively high-energy β + ( E mean = 640 keV), meaning that the positrons have a long mean-free path length ( R mean = 2.5 mm) compared to other popular positron-emitting radiometals such as 64 Cu ( E mean = 278.2 keV, R mean = 0.56 mm) and 89 Zr ( E mean =402.7 keV, R mean =1.27 mm) [11]. As a result of this higher β + energy and an abundance of gamma emissions (1077, 1153, 1854, 1921 keV), the image quality of 86 Y-PET scans is reported as being sub-optimal.…”

Section: Introductionmentioning

confidence: 99%

A comparative evaluation of the chelators H 4 octapa and CHX-A″-DTPA with the therapeutic radiometal 90 Y

Price

Edwards

Carnazza

et al. 2016

Nuclear Medicine and Biology

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Objectives To compare the radiolabeling performance, stability, and practical efficacy of the chelators CHX-A″-DTPA and H4octapa with the therapeutic radiometal 90Y. Methods The bifunctional chelators p-SCN-Bn-H4octapa and p-SCN-Bn-CHX-A″-DTPA were conjugated to the HER2-targeting antibody trastuzumab. The resulting immunoconjugates were radiolabeled with 90Y to compare radiolabeling efficiency, in vitro and in vivo stability, and in vivo performance in a murine model of ovarian cancer. Results High radiochemical yields (>95%) were obtained with 90Y-CHX-A′-DTPA-trastuzumab and 90Y-octapa-trastuzumab after 15 min at room temperature. Both 90Y-CHX-A″-DTPA-trastuzumab and 90Y-octapa-trastuzumab exhibited excellent in vitro and in vivo stability. Furthermore, the radioimmunoconjugates displayed high tumoral uptake values (42.3 ± 4.0%ID/g for 90Y-CHX-A″-DTPA-trastuzumab and 30.1 ± 7.4%ID/g for 90Y-octapa-trastuzumab at 72 h post-injection) in mice bearing HER2-expressing SKOV3 ovarian cancer xenografts. Finally, 90Y radioimmunotherapy studies performed in tumor-bearing mice demonstrated that 90Y-CHX-A″-DTPA-trastuzumab and 90Y-octapa-trastuzumab are equally effective therapeutic agents, as treatment with both radioimmunoconjugates yielded substantially decreased tumor growth compared to controls. Conclusions Ultimately, this work demonstrates that the acyclic chelators CHX-A″-DTPA and H4octapa have comparable radiolabeling, stability, and in vivo performance, making them both suitable choices for applications requiring 90Y.

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Positron range in PET imaging: non-conventional isotopes

Cited by 65 publications

References 31 publications

Manganese in PET imaging: Opportunities and challenges

Manganese in PET imaging: Opportunities and challenges

Supramolecular Organogels Based on N-Benzyl, N’-Acylbispidinols

A comparative evaluation of the chelators H 4 octapa and CHX-A″-DTPA with the therapeutic radiometal 90 Y

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Positron range in PET imaging: non-conventional isotopes

Cited by 65 publications

References 31 publications

Manganese in PET imaging: Opportunities and challenges

Manganese in PET imaging: Opportunities and challenges

Supramolecular Organogels Based on N-Benzyl, N&rsquo;-Acylbispidinols

A comparative evaluation of the chelators H 4 octapa and CHX-A″-DTPA with the therapeutic radiometal 90 Y

Contact Info

Product

Resources

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Supramolecular Organogels Based on N-Benzyl, N’-Acylbispidinols