Possibilities and limitations for high resolution small animal MRI on a clinical whole-body 3T scanner

Herrmann, Karl‐Heinz; Schmidt, S.; Kretz, Alexandra; Haenold, Ronny; Krumbein, Ines; Metzler, Martin; Gaser, Christian; Witte, Otto W.; Reichenbach, Jürgen R.

doi:10.1007/s10334-011-0284-5

Cited by 52 publications

(59 citation statements)

References 33 publications

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“…Although they excel in showing a topographic brain map, no single imaging modality can provide a direct and complete understanding of the spatiotemporal evolution of cerebral neural activations. 13 Therefore, the application of multimodal imaging systems for the comprehensive assessment of neurophysiological parameters is necessary to accurately reflect injury or recovery. Photoacoustic (PA) imaging is a hybrid nonionizing imaging technology that is based on the intrinsic optical absorption of laser pulses leading to ultrasonic emission due to transient thermoelastic expansion.…”

Section: Introductionmentioning

confidence: 99%

Improving neurovascular outcomes with bilateral forepaw stimulation in a rat photothrombotic ischemic stroke model

et al. 2014

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Abstract. Restoring perfusion to the penumbra during the hyperacute phase of ischemic stroke is a key goal of neuroprotection. Thrombolysis is currently the only approved treatment for ischemic stroke. However, its use is limited by the narrow therapeutic window and side effect of bleeding. Therefore, other interventions are desired that could potentially increase the perfusion of the penumbra. Here, we hypothesized that bilateral peripheral electrical stimulation will improve cerebral perfusion and restore cortical neurovascular response. We assess the outcomes of bilateral forepaw electrical stimulation at intensities of 2 and 4 mA, administered either unilaterally or bilaterally. We developed a combined electrocorticogram (ECoG)-functional photoacoustic microscopy (fPAM) system to evaluate the relative changes in cerebral hemodynamic function and electrophysiologic response to acute, focal stroke. The fPAM system is used for cerebral blood volume (CBV) and hemoglobin oxygen saturation (SO 2 ) and the ECoG for neural activity, namely somatosensory-evoked potential (SSEP), interhemispheric coherence, and alpha-delta ratio (ADR) in response to forepaw stimulation. Our results confirmed the neuroprotective effect of bilateral forepaw stimulation at 2 mA as indicated by the 82% recovery of ADR and 95% improvement in perfusion into the region of penumbra. This experimental model can be used to study other potential interventions such as therapeutic hypertension and hypercarbia.

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Section: Introductionmentioning

confidence: 99%

Improving neurovascular outcomes with bilateral forepaw stimulation in a rat photothrombotic ischemic stroke model

et al. 2014

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“…The downtrades are greater field inhomogeneity and susceptibility to artifacts and higher radiofrequency (RF) power deposition in tissue-measured by the specific absorption rate (SAR) [101]. Overall, although some authors report nice image acquisitions at clinical field strength (1.5-3 T) with optimized coils [29,53,62], or at the very high field of 17.6 T [60,61], it is generally admitted that the range of 7-11.7 T offers the best trade off for most applications in small animals [48]. Systems can be either horizontally or vertically mounted.…”

Section: Technical Considerationsmentioning

confidence: 99%

High field magnetic resonance imaging of rodents in cardiovascular research

et al. 2016

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Transgenic and gene knockout rodent models are primordial to study pathophysiological processes in cardiovascular research. Over time, cardiac MRI has become a gold standard for in vivo evaluation of such models. Technical advances have led to the development of magnets with increasingly high field strength, allowing specific investigation of cardiac anatomy, global and regional function, viability, perfusion or vascular parameters. The aim of this report is to provide a review of the various sequences and techniques available to image mice on 7-11.7 T magnets and relevant to the clinical setting in humans. Specific technical aspects due to the rise of the magnetic field are also discussed.

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“…To obtain an occlusion-free view of the brain, we employ a skull stripping approach, described in Section 4, at the highest layer. As MRI has a fairly low signal-to-noise ratio [13], we decided to employ depth darkening [19] instead of gradient-based shading as it increases the depth perception of the brain's structures. The depth of the intended target region is visible as a yellow band surrounding the skull and serves as another depth cue.…”

Section: Contextual Viewmentioning

confidence: 99%

Guiding Deep Brain Stimulation interventions by fusing multimodal uncertainty regions

Böck

Lang²,

Evangelista

et al. 2013

2013 IEEE Pacific Visualization Symposium (PacificVis)

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Deep Brain Stimulation (DBS) is a surgical intervention that is known to reduce or eliminate the symptoms of common movement disorders, such as Parkinson's disease, dystonia, or tremor. During the intervention the surgeon places electrodes inside of the patient's brain to stimulate specific regions. Since these regions span only a couple of millimeters, and electrode misplacement has severe consequences, reliable and accurate navigation is of great importance. Usually the surgeon relies on fused CT and MRI data sets, as well as direct feedback from the patient. More recently Microelectrode Recordings (MER), which support navigation by measuring the electric field of the patient's brain, are also used. We propose a visualization system that fuses the different modalities: imaging data, MER and patient checks, as well as the related uncertainties, in an intuitive way to present placement-related information in a consistent view with the goal of supporting the surgeon in the final placement of the stimulating electrode. We will describe the design considerations for our system, the technical realization, present the outcome of the proposed system, and provide an evaluation.

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Possibilities and limitations for high resolution small animal MRI on a clinical whole-body 3T scanner

Abstract: Experimental studies in small rodents requiring high spatial resolution can be performed by using a clinical 3 T scanner with appropriate dedicated coils.

Cited by 52 publications

References 33 publications

Improving neurovascular outcomes with bilateral forepaw stimulation in a rat photothrombotic ischemic stroke model

Improving neurovascular outcomes with bilateral forepaw stimulation in a rat photothrombotic ischemic stroke model

High field magnetic resonance imaging of rodents in cardiovascular research

Guiding Deep Brain Stimulation interventions by fusing multimodal uncertainty regions

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