Possibilities for Correcting Emotional and Behavioral Impairments in Stroke Patients during Rehabilitation Therapy

Котов, С. В.; Исакова, Е. В.; Sheregeshev, V. I.

doi:10.1007/s11055-019-00882-1

Cited by 6 publications

(16 citation statements)

References 28 publications

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“…All 17 studies that were included are randomised controlled studies. [23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] Out of all the studies, seven studies were conducted in the USA, [23][24][25][26][27][28][29] three in Sweden, [30][31][32] two in Australia, 33,34 and the remainder took place in Germany, 35 the Netherlands, 36 China, 37 Brazil, 38 and Russia. 39 Two of the studies were pilot studies.…”

Section: Resultsmentioning

confidence: 99%

“…[23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] Out of all the studies, seven studies were conducted in the USA, [23][24][25][26][27][28][29] three in Sweden, [30][31][32] two in Australia, 33,34 and the remainder took place in Germany, 35 the Netherlands, 36 China, 37 Brazil, 38 and Russia. 39 Two of the studies were pilot studies. 37,38 12 studies had completed at least one follow-up study within 12 months after the completion of the initial study.…”

Section: Resultsmentioning

confidence: 99%

“…23,[26][27][28][30][31][32][35][36][37]39 Three of the studies used iCBT, 23,25,35 whereas others investigated online courses and computer lessons, 33,34 digitally-delivered exercise courses to promote physical activity (exer-gaming), 26,28,29,36,38,39 neuroplasticity-based comput erised cognitive remedi ation, 21 online speed of processing training, 27,28 and technology-based rehabilitation programme (known as telerehabilitation). [30][31][32] A few of the studies considered mental health measures as secondary outcomes, with the primary outcome being improvement of physical activity, 26,28,29,36,38,39 sensory impairment rehabilitation, [30][31][32] or cognitive functional performance. 24,27,37 Study characteristics are summarised in table 1 and table 2.…”

Section: Resultsmentioning

confidence: 99%

“…12 studies determined that the digital mental health intervention used for that study was beneficial in their primary psychological outcome variables. [23][24][25][28][29][30][31][32][33][37][38][39] Out of the 12 studies, one study investigated symptoms of anxiety, 33 seven studies investigated symptoms of depression, [23][24][25]28,29,37,38 and four studies investigated symptoms of both anxiety and depression. [30][31][32]39 The effectiveness of each study was not measured solely by the difference between intervention and control groups.…”

Section: Resultsmentioning

confidence: 99%

“…[23][24][25][28][29][30][31][32][33][37][38][39] Out of the 12 studies, one study investigated symptoms of anxiety, 33 seven studies investigated symptoms of depression, [23][24][25]28,29,37,38 and four studies investigated symptoms of both anxiety and depression. [30][31][32]39 The effectiveness of each study was not measured solely by the difference between intervention and control groups. Due to the novelty of the subject and the scarcity of randomised controlled trial research that has been conducted, the measurement of effectiveness varied by the specific depression and anxiety scales used and by each study's research questions or objectives (table 2).…”

Section: Resultsmentioning

confidence: 99%

See 4 more Smart Citations

Digital interventions for depression and anxiety in older adults: a systematic review of randomised controlled trials

Riadi

Kervin

Dhillon

et al. 2022

The Lancet Healthy Longevity

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Digital interventions for depression and anxiety in older adults: a systematic review of randomised controlled trials

Riadi

Kervin

Dhillon

et al. 2022

The Lancet Healthy Longevity

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PCSK9 Inhibition Reduces Depressive like Behavior in CUMS-Exposed Rats: Highlights on HMGB1/RAGE/TLR4 Pathway, NLRP3 Inflammasome Complex and IDO-1

Hendawy

Salaheldin

Abuelezz

2023

J Neuroimmune Pharmacol

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Ample evidence has pointed to a close link between cardiovascular diseases (CVD) and depression. Inflammatory pathways including the high-mobility-group-box-1 protein, receptor-for-advanced-glycation-end-products and toll-like-receptor-4 (HMGB1/RAGE/TLR4) and nucleotide-binding domain (NOD)–like receptor protein 3 (NLRP3) inflammasome pathways are thought to be crucial players in this link. Activation of these pathways ends by releasing of different inflammatory mediators involved in CVD and depression pathophysiology. In the brain, this inflammatory process enhanced indoleamine2,3-dioxygenase-1 (IDO-1) activation with subsequent alteration in kynurenine/tryptophan levels causing depression. Based on the favorable anti-inflammatory effects of Alirocumab, the proprotein-convertase-subtilisin/kexin-type-9 (PCSK9) inhibitor, used in different CVD, this study was designed to investigate its potential antidepressant effect. The behavioral and neurochemical effects of concomitant treatment of Alirocumab at doses of (4, 8 and 16 mg/kg/week subcutaneously) in Wistar rats exposed to chronic unpredictable mild stress (CUMS) for 6 weeks were assayed. Alirocumab prevented CUMS-induced depressive-like-behaviors exhibited in open-field and forced-swimming tests, and hypothalamus–pituitary–adrenal axis hyperactivity (adrenal gland weight and serum corticosterone). Alirocumab prevented CUMS-induced alteration in hippocampal kynurenine/tryptophan levels and pro-inflammatory cytokines tumor-necrosis-factor-alpha, interleukin-1beta (IL-1β), IL-2 and IL-6. Western blot and PCR analysis showed that Alirocumab favorably modulated the HMGB1/RAGE/TLR4 axis, nuclear-factor-kappa-beta, NLRP3 inflammasome complex and IDO-1 in the hippocampus of CUMS rats. These effects were correlated to the level of PCSK9 expression. The behavioral and biochemical findings indicated the potential antidepressant effect of PCSK9 inhibition by Alirocumab. Graphical Abstract

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The Impact of Digital Mental Health Services on Loneliness and Mental Health: Results from a Prospective, Observational Study

Magid

Sagui-Henson²,

Sweet³

et al. 2023

Int.J. Behav. Med.

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Background Loneliness has increased since the COVID-19 pandemic and negatively impacts mental health. This study examined relationships between loneliness and mental health among adults using a digital mental health platform. Methods A purposive sample of 919 participants (97% response rate) who were newly enrolled in the platform completed a survey on loneliness, depression, anxiety, well-being, stress, social support, and comorbidities at baseline and 3 months. Platform engagement was tracked during this period. We examined baseline differences between lonely and non-lonely participants; associations between loneliness, mental health symptoms, and comorbidities; and changes in loneliness and mental health through engagement in any form of care. Results At baseline, 57.8% of the sample were categorized as lonely. Loneliness was associated with younger age, fewer years of education, and the presence of a comorbidity (p values < .05). Baseline loneliness was associated with greater depression, anxiety, and stress and lower well-being and social support (ps < .001). The percentage of lonely participants decreased at follow-up (57.6% to 52.9%, p = .03). Those who improved in loneliness improved in mental health symptoms, well-being, and social support (ps < .001). Lonely participants who engaged in any form of care reported a greater reduction in loneliness than those who did not engage (p = .04). Conclusions This study confirms previous findings of the high prevalence of loneliness among adults and risk factors for increased loneliness. Findings highlight the potential of digital platforms to reach lonely individuals and alleviate loneliness through remote mental health support.

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Possibilities for Correcting Emotional and Behavioral Impairments in Stroke Patients during Rehabilitation Therapy

Cited by 6 publications

References 28 publications

Digital interventions for depression and anxiety in older adults: a systematic review of randomised controlled trials

Digital interventions for depression and anxiety in older adults: a systematic review of randomised controlled trials

PCSK9 Inhibition Reduces Depressive like Behavior in CUMS-Exposed Rats: Highlights on HMGB1/RAGE/TLR4 Pathway, NLRP3 Inflammasome Complex and IDO-1

The Impact of Digital Mental Health Services on Loneliness and Mental Health: Results from a Prospective, Observational Study

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