The results of a computational investigation of the neutron-physical characteristics and parameters of GT-MHR for different fuels are presented: weapons-grade plutonium, reactor plutonium, low-enrichment uranium, mixed fuel based on uranium and weapons-grade plutonium, fuel based on high-enrichment uranium and thorium, and fuel with added americium and curium. Analysis has shown that GT-MHR can operate on different fuels; this is determined by the structural implementation incorporated in the design and the neutron-physical characteristics of the reactor. This feature makes it possible to use different fuels in this reactor without changing the basic structural components: fuel assemblies, size of the core and reflectors, and the number of reactivity compensation rods.