Possibility of downregulation of atrial natriuretic peptide receptor coupled to guanylate cyclase in peripheral vascular beds of patients with chronic severe heart failure.

Tsutamoto, Takayoshi; Kanamori, Toshiyuki; Morigami, Naoki; Sugimoto, Yukihiko; Yamaoka, Osamu; Kinoshita, Masahiko

doi:10.1161/01.cir.87.1.70

Cited by 157 publications

(115 citation statements)

References 32 publications

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“…Impaired smooth muscle responsiveness is thought to result, in part, from alterations in intracellular cGMP function. 53 When combined with endothelium-dependent mechanisms, these pathophysiologic variations may further confound ED.…”

Section: Vascular Smooth Muscle Abnormalitiesmentioning

confidence: 99%

Why do patients with heart failure suffer from erectile dysfunction? A critical review and suggestions on how to approach this problem

et al. 2005

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Chronic heart failure (HF) is an increasingly common cardiovascular disorder. The goal of healthcare providers is to optimize quality of life in this population, including sexual health. Up to 75% of patients with HF report erectile dysfunction (ED). As HF is a condition with distinct physiologic sequelae, some unique organic and psychological factors contributing to ED in this patient population have been identified, along with risk factors common to the development of coronary artery disease, HF and ED. This review describes contributing factors to ED in the setting of HF and highlights treatment considerations for this distinct patient population.

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Section: Vascular Smooth Muscle Abnormalitiesmentioning

confidence: 99%

Why do patients with heart failure suffer from erectile dysfunction? A critical review and suggestions on how to approach this problem

et al. 2005

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“…Somewhere in HF progression, natriuretic peptides may 'lose' their effect. Response attenuation has multiple potential contributions: increased natiuretic peptides degradation resulting from clearance receptors or neutral endopeptidase upregulation (Andreassi et al 2001, Knecht et al 2002; down-regulation of the natriuretic peptide receptor A (Tsutamoto et al 1993, Bryan et al 2007; second messenger -cGMP -response attenuation (Lourenco et al 2009), alternate processing after secretion and degradation into a multitude of less active forms (Hawkridge et al 2005, Liang et al 2007, Martinez-Rumayor et al 2008. Dipeptidyl-peptidase IV cleaves the functional and active BNP1-32 into the less active BNP3-32 form and has gained increasing attention has part of this alternate processing and inactivation of natriuretic peptides in HF (Brandt et al 2006, Lourenco et al 2013.…”

Section: Discussionmentioning

confidence: 99%

Prognostic prediction in acute heart failure patients with extreme BNP values

et al. 2017

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Background: Some patients have good prognosis despite elevated B-type natriuretic peptide (BNP), while others have ominous outcome with low BNP. We aimed at characterising these groups of patients. Methods: We analysed patients prospectively included in an acute HF registry. Vital status within 1-year post discharge was ascertained. A receiver-operating characteristic curve was used to define discharge BNP cut-offs for 1-year death prediction. Among survivors, we compared patients with low and not-low BNP (cut-off 400 pg/mL); and among non-survivors those with high vs not-high BNP (cut-off 2000 pg/mL). In the specific subgroups of patients with low and high BNP, mortality predictors were assessed with multivariate Cox-regression analysis. Results: We studied 584 patients, median age 78 years, 62.5% had HF with reduced ejection fraction; and 199 (34.1%) died during the first year. Non-survivors were very homogeneous irrespective of BNP, survivors were substantially different. In patients discharged with BNP <400 pg/mL, increasing age independently predicted death; when BNP !2000 pg/mL death predictors were higher NYHA class, and non-use of evidence-based therapy. BNP was outcome associated in both groups. Conclusions: Different prognostic predictors may play a role in different BNP levels. We suggest that risk stratification in HF would probably be more accurate if made on top of BNP knowledge.

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“…Increased cardiac expression of ANP and BNP and release of this peptides into the circulation is a characteristic feature in heart failure. Despite this elevation, the physiologic response to these peptides is diminished [33,34]. Currently two studies were published describing hyporesponsiveness of cardiac and renal tissues to ANP in congestive heart failure.…”

Section: Discussionmentioning

confidence: 99%

Visinin-like protein 1 regulates natriuretic peptide receptor B in the heart

Buttgereit

Qadri

Monti

et al. 2010

Regulatory Peptides

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Accumulating evidence indicates that Visinin-like protein-1 (VILIP-1), a member of the family of neuronal calcium sensor proteins (NCS), modulates a variety of processes in extra-neuronal tissues. In this study, we describe VILIP-1 expression in the human heart, rat cardiomyocytes, and H9c2 cells, and demonstrate that VILIP-1 regulates the cell surface localization of natriuretic peptide receptor B (NPR-B). In preparations from failing hearts, we observed VILIP-1 downregulation and reduced NPR-B signalling. In conclusion, VILIP-1 deficiency may be responsible for the reduced efficiency of the natriuretic peptide system in cardiac hypertrophy and heart failure and may therefore serve as pharmacological target.3

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Possibility of downregulation of atrial natriuretic peptide receptor coupled to guanylate cyclase in peripheral vascular beds of patients with chronic severe heart failure.

Abstract: These results indicate that downregulation of ANP receptors coupled to guanylate cyclase may occur in the peripheral vascular beds of patients with chronic severe CHF.

Cited by 157 publications

References 32 publications

Why do patients with heart failure suffer from erectile dysfunction? A critical review and suggestions on how to approach this problem

Why do patients with heart failure suffer from erectile dysfunction? A critical review and suggestions on how to approach this problem

Prognostic prediction in acute heart failure patients with extreme BNP values

Visinin-like protein 1 regulates natriuretic peptide receptor B in the heart

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