Possibility of Interactions between Prescription Drugs and OTC Drugs (2nd Report)-Interaction between Levodopa Preparation and OTC Kampo Medicines for Upset Stomach-

Sunagane, Nobuyoshi; Aikawa, Masanori; Ohta, Takafumi; Uruno, Tsutomu

doi:10.1248/yakushi.126.1191

Cited by 7 publications

(3 citation statements)

References 6 publications

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“…Herb-drug interactions may affect all these stages, thus possibly resulting in a decreased therapeutic effect of levodopa. Preliminary in vivo results demonstrated that levodopa, when in combination with over the counter (OTC) drugs used for stomach burning (Table 1), resulted in a significantly lower area under the curve (AUC) for levodopa (Sunagane et al, 2006). However, these results were not supported by a concise explanation or hypothetical mechanisms.…”

Section: Interactions With Levodopamentioning

confidence: 99%

Herb‐drug interactions: A short review on central and peripheral nervous system drugs

Bernardo,

Valentão

2024

Phytotherapy Research

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Herbal medicines are widely perceived as natural and safe remedies. However, their concomitant use with prescribed drugs is a common practice, often undertaken without full awareness of the potential risks and frequently without medical supervision. This practice introduces a tangible risk of herb‐drug interactions, which can manifest as a spectrum of consequences, ranging from acute, self‐limited reactions to unpredictable and potentially lethal scenarios. This review offers a comprehensive overview of herb‐drug interactions, with a specific focus on medications targeting the Central and Peripheral Nervous Systems. Our work draws upon a broad range of evidence, encompassing preclinical data, animal studies, and clinical case reports. We delve into the intricate pharmacodynamics and pharmacokinetics underpinning each interaction, elucidating the mechanisms through which these interactions occur. One pressing issue that emerges from this analysis is the need for updated guidelines and sustained pharmacovigilance efforts. The topic of herb‐drug interactions often escapes the attention of both consumers and healthcare professionals. To ensure patient safety and informed decision‐making, it is imperative that we address this knowledge gap and establish a framework for continued monitoring and education. In conclusion, the use of herbal remedies alongside conventional medications is a practice replete with potential hazards. This review not only underscores the real and significant risks associated with herb‐drug interactions but also underscores the necessity for greater awareness, research, and vigilant oversight in this often‐overlooked domain of healthcare.

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Section: Interactions With Levodopamentioning

confidence: 99%

Herb‐drug interactions: A short review on central and peripheral nervous system drugs

Bernardo,

Valentão

2024

Phytotherapy Research

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“…For example, branched-chain amino acids may be administered to stimulate appetite; however, this resembles a high-protein diet, which may induce levodopa wearing off. Herbal remedies for dyspepsia, particularly those with metallic additives, have been shown to inhibit levodopa absorption [123] and may also worsen motor complications; thus, these remedies should be avoided in patients with PD.…”

Section: Gastrointestinal Disordersmentioning

confidence: 99%

Potential Influences of Complementary Therapy on Motor and Non-Motor Complications in Parkinsonʼs Disease

Zesiewicz

Evatt

2009

CNS Drugs

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Nearly two-thirds of patients with Parkinson's disease (PD) use vitamins or nutritional supplements, and many more may use other complementary therapies, yet <50% of patients have discussed the use of these complementary therapies with a healthcare professional. Physicians should be aware of the complementary therapies their patients with PD are using, and the possible effects of these therapies on motor and non-motor symptoms. Complementary therapies, such as altered diet, dietary supplements, vitamin therapy, herbal supplements, caffeine, nicotine, exercise, physical therapy, massage therapy, melatonin, bright-light therapy and acupuncture, may all influence the symptoms of PD and/or the effectiveness of dopaminergic therapy. Preliminary evidence suggests complementary therapy also may influence non-motor symptoms of PD, such as respiratory disorders, gastrointestinal disorders, mood disorders, sleep and orthostatic hypotension. Whenever possible, clinicians should ensure that complementary therapy is used appropriately in PD patients without reducing the benefits of dopaminergic therapy.

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“…HM use has increased over the last two decades in various places, both developed and developing countries [4][5][6][7]. Along with the rise in their use comes the risk of interaction with conventional medicines when prescribed [8][9][10]. The potential for interaction between herbs and prescription drugs is of concern because the pharmacokinetics of one or more medications taken simultaneously can be altered and can lead to clinically significant toxicities [11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Perceptions and Practices Regarding Herbal Medicine Prescriptions among Physicians in Greater Beirut

Alaaeddine¹,

Khayat²,

Alawleh³

2014

LMJ

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• AIMS AND OBJECTIVES : This survey aimed at assessing the perceptions of physicians regarding the appropriateness of prescribing herbal medicines (HM), their prescribing patterns and their knowledge regarding the interaction between HM and conventional drugs. BACKGROUND : No data are currently available in Lebanon concerning the frequency of HM prescription and indications. HM poorly prescribed can affect the overall quality of health among patients taking conventional drugs. METHODS : This descriptive survey study was conducted in the Greater Beirut area in Lebanon during May-June 2009. All Primary Health Care (PHC) physicians in private community-based solo practice were identified from the Lebanese Order of Physicians listing, contacted and invited to participate. Those who agreed had to complete a pre-piloted face-to-face questionnaire. RESULTS : Of two hundred twelve participating physicians, 45% routinely prescribed HM to their patients. Between 64 to 67% prescribers believed that HM have more benefits, faster results and fewer side effects than conventional drugs. In addition, 58% thought that HM were less expensive, and 76% that they were easier to take than conventional drugs. More importantly, in a series of eight questions concerning the physicians' knowledge about the possible mechanism of drug-herb interactions, the general tendency was towards poor knowledge. CONCLUSIONS : A good percentage of PHC physicians who routinely prescribe HM do not know their mechanism of action or their possible interactions with the conventional drugs. Knowledge about mechanism of drug-herb interactions should be an integral part of the medical curriculum. RELEVANCE TO CLINICAL PRACTICE : The knowledge about HM should be an integral part of the medical curriculum as they are frequently prescribed by PHC physicians.

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Possibility of Interactions between Prescription Drugs and OTC Drugs (2nd Report)-Interaction between Levodopa Preparation and OTC Kampo Medicines for Upset Stomach-

Cited by 7 publications

References 6 publications

Herb‐drug interactions: A short review on central and peripheral nervous system drugs

Herb‐drug interactions: A short review on central and peripheral nervous system drugs

Potential Influences of Complementary Therapy on Motor and Non-Motor Complications in Parkinsonʼs Disease

Perceptions and Practices Regarding Herbal Medicine Prescriptions among Physicians in Greater Beirut

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