Possibility of nano-local element analysis by near-field laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS): New experimental arrangement and first application

Zoriy, Miroslav; Kayser, Markus; Becker, J. Sabine

doi:10.1016/j.ijms.2008.03.008

Cited by 44 publications

(44 citation statements)

References 19 publications

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“…To minimize the vibrations during the measurements the Iso-Plate vibration damping system from Thorlabs Inc. (Newton, NJ) was used. Further details about NF-LA-ICP-MS experimental setup can be found elsewhere [30,31].…”

Section: Nf-la-icp-ms Measurements Of Ida-chip Bioelectronic Device Amentioning

confidence: 99%

“…Ion intensity of 197 Au ϩ was measured during "single shots" of the unfocused laser when the tip of the thin Ag needle far (d Ͼ10 mm), no near-field enhancement was observed; and at a distance of the needle about 10 nm (and lower) from the sample surface, near-field enhancement of incident laser energy took place. The controlling of tip-to-sample distance was performed via measurement of tunnel current by developed tuning system as described elsewhere [30,31]. First, the needle slowly approached the sample surface (no tunnel current was measured).…”

Section: For Nanolocal Analysis By Nf-la-icp-ms At Nm Resolutionmentioning

confidence: 99%

“…The principle of the procedure is to apply an enhancement of incident laser energy (light) on the tip of a thin Ag needle (diameter ϳ 200 nm). "Focused" in this way, the laser beam will produce an ablation crater in the size proportional to the needle diameter used [30,31]. An experimental arrangement of NF-LA-ICP-MS (including controlling system for sample-to-tip distance via the measurements of tunnel current between the needle and sample surface) was successfully established in our laboratory and applied for nanolocal analysis of thin (20 nm) Au film deposited onto a Si substrate [30].…”

mentioning

confidence: 99%

“…"Focused" in this way, the laser beam will produce an ablation crater in the size proportional to the needle diameter used [30,31]. An experimental arrangement of NF-LA-ICP-MS (including controlling system for sample-to-tip distance via the measurements of tunnel current between the needle and sample surface) was successfully established in our laboratory and applied for nanolocal analysis of thin (20 nm) Au film deposited onto a Si substrate [30]. The observed craters ranged from 500 nm to about 1 m in diameter and were dependent on the needle used as well as on the "sample-to-tip" distance.…”

mentioning

confidence: 99%

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Metal imaging on surface of micro- and nanoelectronic devices by laser ablation inductively coupled plasma mass spectrometry and possibility to measure at nanometer range

Zoriy¹,

Mayer

Becker³

2009

J. Am. Soc. Mass Spectrom.

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An analytical mass spectrometric method for the elemental analysis of nano-bioelectronic devices involved in bioengineering research was developed and applied for measurements of selected metals (Au, Ti, Pt, Cr, etc.) on interdigitated electrode array chips (IDA-chip). An imaging laser ablation inductively coupled plasma mass spectrometric (LA-ICP-MS) procedure was used to map the elements of interest on the surface of the analyzed sample. The obtained images of metals were in a good agreement and corresponded to the micro-and nanofabricated metal electrode pattern. For the analysis at nanometer resolution scale a NF-LA-ICP-MS (NF-near-field) procedure was applied, which utilize thin Ag needle to enhance laser beam energy and improve spatial resolution of the method. The results show a ϳ100ϫ enhancement of analyte signal, when the needle was positioned in the "near-field region" to the sample surface and the laser shot was performed. In addition, mass spectrometric studies of reproducibly for five separated NF-LA shots in different places of analyzed sample yielded an RSD of the measurement of 16%. io engineering (or biological engineering), including biomedical engineering and nanobiotechnology, is a new, challenging, and rapidly growing high-tech research field [1,2]. The use of biomolecules as the building blocks of higher-level functional devices will lead to applications that range from the integration of biomaterials with electronics in recognition or sensing devices [3]. Bioelectronics research also exploits to use biomolecules to perform the electronic functions that semiconductor devices currently perform, thereby offering the potential to increase integration in combination with additional functionality at the nanometer level. However, the integration of biomolecules or even whole cells with inorganic devices brings several challenges about as there are, for instance, operation of the electronic components under physiological conditions, electrically, biochemically as well as size-adapted bioinorganic interfaces, and biocompatibility of the electronic devices. The implementation of these challenges and the realization of functional bioelectronic junctions require interdisciplinary research, including microengineering, biotechnology, surface chemistry, and analytical research.The fabrication of bioelectronic component on the basis of silicon microtechnology facilitates high integration densities, high spatial resolution, combining signal recording and transducing in one device at relatively low production costs. To build and assemble bioinorganic electronic components with well defined and optimized features, it usually requires control over impurities of trace levels contaminations, which can influence the physical, electrical, magnetic, and chemical properties of thin layered systems. In particular, the biocompatibility of device can be strongly affected by organic and inorganic impurities introduced during the fabrication processes. Therefore, powerful and sensitive trace analytical techniques are ne...

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Section: Nf-la-icp-ms Measurements Of Ida-chip Bioelectronic Device Amentioning

confidence: 99%

Section: For Nanolocal Analysis By Nf-la-icp-ms At Nm Resolutionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Metal imaging on surface of micro- and nanoelectronic devices by laser ablation inductively coupled plasma mass spectrometry and possibility to measure at nanometer range

Zoriy¹,

Mayer

Becker³

2009

J. Am. Soc. Mass Spectrom.

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“…the tip of a thin Ag needle) immersed in the radiation field. Becker et al [35,36] have investigated the use of NF-LA-ICP-sector field MS (SFMS) for elemental analysis at the nanometre scale in twodimensional gels, biological samples and thin Au films. The proposed NF-LA-ICP-SFMS arrangement employed thin Ag needles (d~180-250 nm) electrolytically etched, and the distance between the needle and the sample surface was controlled by measuring the tunnel current.…”

Section: Laser Ablation Inductively Coupled Plasma Mass Spectrometrymentioning

confidence: 99%

Inorganic mass spectrometry as a tool for characterisation at the nanoscale

et al. 2009

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Inorganic mass spectrometry techniques may offer great potential for the characterisation at the nanoscale, because they provide unique elemental information of great value for a better understanding of processes occurring at nanometre-length dimensions. Two main groups of techniques are reviewed: those allowing direct solid analysis with spatial resolution capabilities, i.e. lateral (imaging) and/or indepth profile, and those for the analysis of liquids containing colloids. In this context, the present capabilities of widespread elemental mass spectrometry techniques such as laser ablation coupled with inductively coupled plasma mass spectrometry (ICP-MS), glow discharge mass spectrometry and secondary ion/neutral mass spectrometry are described and compared through selected examples from various scientific fields. On the other hand, approaches for the characterisation (i.e. size, composition, presence of impurities, etc.) of colloidal solutions containing nanoparticles by the well-established ICP-MS technique are described. In this latter case, the capabilities derived from the on-line coupling of separation techniques such as field-flow fractionation and liquid chromatography with ICP-MS are also assessed. Finally, appealing trends using ICP-MS for bioassays with biomolecules labelled with nanoparticles are delineated.

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Mass Spectrometry in Inorganic and Bioinorganic Chemistry

Becker

Becker²

2005

Encyclopedia of Inorganic Chemistry

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Mass spectrometry (MS) in inorganic and bioinorganic chemistry has been established using sensitive analytical techniques in quite different application fields: the determination of major, minor, and trace element concentrations; for the characterization of surfaces; for precise and accurate isotope ratio measurements; and for the structural analysis of organic and bioorganic compounds. The review gives an overview on different mass spectrometric techniques and their applications

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Possibility of nano-local element analysis by near-field laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS): New experimental arrangement and first application

Cited by 44 publications

References 19 publications

Metal imaging on surface of micro- and nanoelectronic devices by laser ablation inductively coupled plasma mass spectrometry and possibility to measure at nanometer range

Metal imaging on surface of micro- and nanoelectronic devices by laser ablation inductively coupled plasma mass spectrometry and possibility to measure at nanometer range

Inorganic mass spectrometry as a tool for characterisation at the nanoscale

Mass Spectrometry in Inorganic and Bioinorganic Chemistry

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