Possibility of scrub typhus in fever of unknown origin (FUO) cases: An experience from Rajasthan

Bithu, Rameshwari; Kanodia, V; Maheshwari, RK

doi:10.4103/0255-0857.142241

Cited by 40 publications

(23 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Scrub typhus positivity was significantly higher among women, 314 (35.9%) compared with men, 210 (22.8%) with the ratio of 1.5:1. Likewise, Bithu et al, 22 Vivekanandan et al 23 and Saleem et al 24 also found female preponderance in their study. In contrast, Jyothi et al 25 and Medhi et al 26 found that prevalence rate for scrub typhus was higher among men.…”

Section: Correlation Between Elisa and Weil-felix Testsupporting

confidence: 55%

Burden of scrub typhus among patients with acute febrile illness attending tertiary care hospital in Chitwan, Nepal

et al. 2020

View full text Add to dashboard Cite

ObjectivesScrub typhus is an emerging neglected tropical disease, reported from many parts of Asia including Nepal. This study aims to determine the seroepidemiology of scrub typhus among febrile patients attending Chitwan Medical College Teaching Hospital (CMC-TH), Bharatpur, Nepal.Study design and settingThis was a hospital laboratory-based prospective study conducted in CMC-TH (a 750-bed hospital) located in Bharatpur, Chitwan district of Nepal.ParticipantsA total of 1797 patients visiting CMC-TH with acute febrile illness (temperature more than 38°C) were enrolled in this study.MethodsA total of 1797 blood samples were collected from patients presenting with acute febrile illness. The samples were processed for detection of antibody for scrub typhus by ELISA for specific IgM antibody and Weil-Felix test.ResultsOut of 1797 serum sample of febrile patients, 524 (29.2%) were scrub typhus positive. Maximum seropositive cases were from Chitwan district, 271 (51.7%) with predominance among women, 314 (35.9%). Scrub typhus was common among age group 51–60 years (37.2%) and farmers, 182 (37.8%). Highest seropositivity was found in July, 60 (57.7%). Fever was common clinical symptom. Thrombocytopenia was seen in 386 (73.7%) and raised transaminase aspartate aminotransferase, 399 (76.1%) among seropositive cases. Weil-Felix test positive were 397 (22.1%) and IgM ELISA positive were 524 (29.2%). The correlation between IgM ELISA and Weil-Felix test showed statistically significant association (r=0.319, p<0.001).ConclusionHigh prevalence of scrub typhus implies that patients with acute febrile illness should be investigated for scrub typhus with high priority. There is utmost need of reliable diagnostic facilities at all levels of healthcare system in Nepal. Infection with scrub typhus was found high and this calls for an urgent need to introduce vaccine against scrub typhus. More sustain and vigorous awareness programmes need to be promoted for early diagnosis, treatment and control.

show abstract

Section: Correlation Between Elisa and Weil-felix Testsupporting

confidence: 55%

Burden of scrub typhus among patients with acute febrile illness attending tertiary care hospital in Chitwan, Nepal

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The study by Bithu et al, in their study reported that out of 133 infected with Scrub typhus, 80 (62%) were females and 53 (37.3%) males. 28 Vivekanandan M et al, also found female prepordance in their study. 29 Scrub typhus positivity was significantly higher among females as compared to males.…”

Section: 27supporting

confidence: 51%

Threat of scrub typhus in post-earthquake Nepal

2017

View full text Add to dashboard Cite

Scrub typhus is a potentially fatal zoonotic infection, reported from many parts of Asia including Nepal. There is increasing reports of outbreak of Scrub typhus, after the earthquake hit Nepal on April 25, 2015. The recent outbreak of Scrub typhus posed problems in diagnosis and treatment of the disease. It may be related to poor awareness of the disease or lack of suspicion for Scrub typhus which often presents with clinical features indistinguishable from typhoid fever. Since, various parts of Nepal appeared to be suitable hubs for Scrub typhus, the clinical suspicion of Scrub typhus in the differential diagnosis of fever of unknown origin (FUO) is of utmost importance to prevent mortality and morbidity. This is a prospective study conducted in Chitwan Medical College (CMC), Chitwan, Nepal. This study was carried out over a period of 4 months extending from June 2016 to September 2016. A total of 410 serum samples were collected from all patients visiting CMC, clinically suspected of having Scrub typhus infection. The samples were processed for the detection of IgM antibodies for Scrub typhus by ELISA. Results: A total of 410 samples from patients suspected with Scrub typhus infection were processed which included 200 males and 210 females. Out of total 410 samples tested, 181 (44.1%) were seropositive for Scrub typhus. Seropositivity was highest 25.9% among the age group 11-20 years of age. Females were infected more than males. This study implies the re-emergence of Scrub typhus in different regions of Nepal. Although the disease is endemic in our country, it is grossly underdiagnosed owing to non-specific clinical presentation and lack of diagnostic facilities. It is thus suggested that high index of suspicion should be maintained for cases presenting with febrile illness. Infection with Scrub typhus was found high and this calls for an urgent need to introduce vaccine against Scrub typhus.

show abstract

“…The results were similar to other studies that found dengue was responsible for febrile illnesses in sub-Saharan Africa and other countries [8][9][10]. A study in Rajasthan, India [11] presented 49.1% of patients with FUO that were confirmed by scrub typhus immunoglobulin M antibodies by ELISA and had a similar result to another prospective study among patients with FUO in Chennai City, South India [12], presenting 23% of patients positive for immunoglobulin M antibodies against Orientia tsutsugamushi. FUO is one of the diseases notified by law under the National Communicable Disease Surveillance System in Thailand.…”

Section: Discussionsupporting

confidence: 89%

Zoonotic and vector borne agents causing disease in adult patients hospitalized due to fever of unknown origin in Thailand

Hinjoy¹,

Wacharapluesadee²,

Iamsirithaworn³

et al. 2017

APJTD

View full text Add to dashboard Cite

show abstract

Possibility of scrub typhus in fever of unknown origin (FUO) cases: An experience from Rajasthan

Abstract: The present study emphasises the importance of scrub typhus among cases of FUO especially after rainy season and during early cooler months. The study also highlights the significance of ELISA method for rapid and early reporting and ruling out scrub typhus in FUO cases.

Cited by 40 publications

References 14 publications

Burden of scrub typhus among patients with acute febrile illness attending tertiary care hospital in Chitwan, Nepal

Burden of scrub typhus among patients with acute febrile illness attending tertiary care hospital in Chitwan, Nepal

Threat of scrub typhus in post-earthquake Nepal

Zoonotic and vector borne agents causing disease in adult patients hospitalized due to fever of unknown origin in Thailand

Contact Info

Product

Resources

About