Possible action of grape seed oil on brain toxicity induced by methomyl or imidacloprid of male rats

Moeen, Doaa; Amer, Afnan; Ismail, Nadia; Ali, Elham H.A.

doi:10.21608/jsrs.2018.25659

Cited by 1 publication

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“…In addition, administration of methomyl resulted in an increment in SOD activity which may be due to an over production of ROS that lead to SOD production to overcome the induced oxidative stress (53). Also, the increment may be a physiological response of the animal body to justify the toxic effect of methomyl on the body due to its role in scavenging ROS as mentioned by Moeen et al (54). The increment in SOD activity comes in agreement with Patil et al (35).…”

Section: Discussionsupporting

confidence: 80%

The Protective Role of Thymol Against Methomyl- Induced Toxicity in Male Rats: Clinico-Biochemical, Histopathological and Immuno-Histochemical Studies

Aboushouk,

Mehana,

Oda

et al. 2021

SVR

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This experiment was carried out to evaluate the presumptive protective effect of thymol (T) against methomyl (M) - induced toxicity in male albino rats. Therefore, forty adult healthy male albino rats were randomly divided into 4 equal groups as follow: control group, intoxicated group received methomyl (4 mg/kg b.wt./day), treated group received thymol (100 mg/kg b.wt.), and co-treated group received both methomyl and thymol with the previous doses. The treatment regimens were given orally three times a week, day after day, for eight weeks. Biochemically, the M- intoxicated rats revealed a significant increase in the serum aminotransferases (ALT& AST) and gamma glutamyle transferase (GGT) activities, total, direct and indirect bilirubin, total cholesterol, triglyceride, low density lipoprotein cholesterol (LDL-C), urea, malondialdehyde (MDA) levels and superoxide dismutase (SOD) activity, in addition to a significant decrease in serum albumin and testosterone levels with a significant increase in the percentage of sperm abnormalities in comparison with the control rats. Regarding to the histopathological examination, M- intoxicated group showed degenerative and necrotic lesions in the hepatic, renal and testicular tissues. But, the co- treatment with thymol ameliorated the M- induced biochemical alterations, oxidative stress and apoptosis and improved tissues architecture. It could be concluded that co-treatment with thymol may provide a prolonged remedy against methomyl -induced toxicity.

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Section: Discussionsupporting

confidence: 80%