Possible amelioration of oxidative stress damage via cyclo-oxygenase pathway by aqueous extract of Terminalia catappa leaves in alloxan induced diabetic rats

Ben, Ezekiel E.; Asuquo, Asuquo Etim; Owu, Daniel U.

doi:10.30574/gscbps.2021.16.2.0215

Cited by 3 publications

(1 citation statement)

References 62 publications

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“…The use of medicinal plant in management of diseases have been advocated by WHO [21] and this has instigated many research interests to develop alternative medicine to sustain human race in the face of disease and drug availability challenges. Terminalia catappa have been reported by many researchers and our team as useful antidiabetic [22], anti-inflammatory [23] and anti-oxidative [24] agents. This study seeks to investigate the atherogenic indices in diabetic rats treated with aqueous and methanol extracts of Terminalia catappa leaves in diabetic rats.…”

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confidence: 97%

Assessment of atherogenic indices and modification of lipid profiles by aqueous and methanol extracts of Terminalia catappa leaves in diabetic rats

Ezekiel E. Ben,

Roseline Ateb,

Asuquo E. Asuquo

et al. 2024

World J. Adv. Res. Rev.

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Atherogenic indices are useful markers for prediction of cardiovascular diseases. This study investigates atherogenic indices in diabetic rats treated with different fractions of Terminalia catappa leaf extract. A total of Forty-two [42] male Wistar rats were randomly shared into 7 groups of 6 rats per group. Group 1 [control] received 5 ml/kg body weight of distilled water orally. Group 2 was treated with aqueous leaf extract of T. catappa at 130 mg/kg body weight orally while Group 3, diabetic untreated group orally received distilled water, 5ml/Kg body weight. Groups 4 and 5 were diabetic rats treated respectively with 130 mg/Kg body weight of aqueous leaf extract of T. catappa and subcutaneous administration of insulin, 0.75 U/Kg body weight. Group 6 received methanol fraction of T. catappa leaf extract; 130 mg/Kg body weight and group 7 was administered orally with 30 mg/Kg body weight of aspirin. Diabetes was induced with streptozotocin; 65 mg/Kg body weight. Results showed significant [p < 0.05] increase in TC, TG, LDL-c and VLDL-c in diabetic untreated group and significant reduction in HDL-c. These lipids were reduced and HDL-c increased significantly [p < 0.05] in aqueous and methanol extracts of T. catappa leaves treated groups. There was significant [p< 0.05] Fasting Blood Glucose reduction in both fractions. Therefore, modifications of lipid profile and reduction of atherogenic index in diabetic rats were similar in aqueous and methanol extracts of T. catappa leaves suggesting the potentials of preventing cardiovascular complications in diabetes mellitus.

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Section: Introductionmentioning

confidence: 97%

Assessment of atherogenic indices and modification of lipid profiles by aqueous and methanol extracts of Terminalia catappa leaves in diabetic rats

Ezekiel E. Ben,

Roseline Ateb,

Asuquo E. Asuquo

et al. 2024

World J. Adv. Res. Rev.

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Sustainable Role of Terminalia catappa Extract for Maintaining Antioxidant Activities in Wistar Rats

Iheagwam,

Adedoyin

2024

IOP Conf. Ser.: Earth Environ. Sci.

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Oxidative stress is linked to various diseases, including cancer and cardiovascular disorders, due to the imbalance between reactive oxygen species and the body’s antioxidant defenses. The use of natural antioxidants presents a sustainable approach to mitigating oxidative damage, aligning with Sustainable Development Goals 3 and 12. This study evaluates the impact of repeated oral administration of Terminalia catappa aqueous extract (AETC) on antioxidant activities in Wistar rats over 28 days. The enzymatic activities and non-enzymatic concentration of endogenous antioxidants were investigated in the plasma and tissues at the end of the experiment. Results indicated increased renal superoxide dismutase, hepatic peroxidase, erythrocyte and renal glutathione-S-transferase activities. Hepatic reduced glutathione concentration was increased while plasma and renal malondialdehyde concentrations were reduced. These results emphasise AETC’s tissue-specific antioxidant effects and its potential as a protective agent against oxidative damage, consolidating the ethnobotanical use of Terminalia catappa leaves as a tonic for health-improving benefits promoting good health in addition to advocating for ecofriendly and sustainable health solutions. Further elucidatation of AETC antioxidant mechanisms and optimisation of its therapeutic applications is required.

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Terminalia catappa Extract Palliates Redox Imbalance and Inflammation in Diabetic Rats by Upregulating Nrf-2 Gene

Iheagwam

Batiha

Ogunlana

et al. 2021

International Journal of Inflammation

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This study aims at evaluating the ameliorative role of Terminalia catappa aqueous leaf extract (TCA) on hyperglycaemia-induced oxidative stress and inflammation in a high-fat, low dose streptozotocin-induced type 2 diabetic rat model. Experimental rats were treated orally with 400 and 800 mg/kg bw TCA daily for four weeks. Antioxidant enzyme activities, plasma glucose concentration, protein concentration, oxidative stress, and inflammation biomarkers were assayed using standard methods. Hepatic relative expressions of tumour necrosis factor-alpha (TNF-α), interleukin-six (IL-6), and nuclear factor-erythroid 2 related factor 2 (Nrf-2) were also assessed. Molecular docking and prediction of major TCA phytoconstituents’ biological activity related to T2DM-induced oxidative stress were evaluated in silico. Induction of diabetes significantly ( p < 0.05 ) reduced superoxide dismutase, glutathione-S-transferase, and peroxidase activities. Glutathione and protein stores were significantly ( p < 0.05 ) depleted, while glucose, MDA, interleukin-six (IL-6), and tumour necrosis factor-α (TNF-α) concentrations were significantly ( p < 0.05 ) increased. A significant ( p < 0.05 ) upregulation of hepatic TNF-α and IL-6 expression and downregulation ( p < 0.05 ) of Nrf-2 expression were observed during diabetes onset. TCA treatment significantly ( p < 0.05 ) modulated systemic diabetic-induced oxidative stress and inflammation, mRNA expression dysregulation, and dysregulated macromolecule metabolism. However, only 800 mg/kg TCA treatment significantly ( p < 0.05 ) downregulated hepatic TNF-α expression. 9-Oxabicyclo[3.3.1]nonane-2,6-diol and 1,2,3-Benzenetriol bound comparably to glibenclamide in Nrf-2, IL-6, and TNF-α binding pockets. They were predicted to be GST A and M substrate, JAK2 expression, ribulose-phosphate 3-epimerase, NADPH peroxidase, and glucose oxidase inhibitors. These results suggest that TCA ameliorates hyperglycaemia-induced oxidative stress and inflammation by activating Nrf-2 gene.

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Possible amelioration of oxidative stress damage via cyclo-oxygenase pathway by aqueous extract of Terminalia catappa leaves in alloxan induced diabetic rats

Cited by 3 publications

References 62 publications

Assessment of atherogenic indices and modification of lipid profiles by aqueous and methanol extracts of Terminalia catappa leaves in diabetic rats

Assessment of atherogenic indices and modification of lipid profiles by aqueous and methanol extracts of Terminalia catappa leaves in diabetic rats

Sustainable Role of Terminalia catappa Extract for Maintaining Antioxidant Activities in Wistar Rats

Terminalia catappa Extract Palliates Redox Imbalance and Inflammation in Diabetic Rats by Upregulating Nrf-2 Gene

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