Possible anti-tumour promoters: BI- and tetraflavonoids from Lophira alata

Murakami, Akira; Tanaka, Shigeo; Ohigashi, Hajime; Hirota, Mitsuru; Irie, Ryozo; Takeda, Nobuhiro; Tatematsu, Akira; Koshimįzu, Koichi

doi:10.1016/0031-9422(92)83612-3

Cited by 28 publications

(12 citation statements)

References 10 publications

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“… Enveloped viruses Béládi et al (1977) Quercetin Chenopodium quinoa Potato virus X French and Towers (1992) Quercetin 3-methyl ether Found as the aglycone in the leaves of Compositae Antiviral activity Cody et al (1986) Quercetin 3- O -(2″-galloyl)-β-D-galactopyranoside Acer okamotoanum Nakai HIV-1 integrase Kim et al (1998) Quercetagetin Found in the flowers of many spp. of Compositae Rauscher murine leukemia and HIV Cody et al (1986) Rutin Fagopyrum esculentum Moench Pseudorabies and vesicular stomatitis virus Béládi et al (1977) Taxifolin Acacia catechu Antiviral activity Harborne (1988) Volkensiflavone Rhus succedania L. Influenza B virus Lin et al (1997) ; Lin et al (1999) Ternatin and Melaternatin Evodia madagascariensis Baker HSV-1, HSV-2, adenovirus type 2, poliovirus type 2, and VSV type 2 Simöes et al (1990) Afromosin and Formononetin Wisteria brachybotrys Sieb Epstein-Barr virus early antigen Konoshima et al (1989) Axillarin, Chrysosphenol B, and Chrysosplenol C Chrysosplenium tosaense Rhinovirus Tsuchiya et al (1985) Lophirone F, Azobechalcone, and Isolophirachalcone Lophira alata Epsein-Barr virus early antigen induction test Murakami et al (1992) Centaurein and Jacein Centaurea nigra L. Herpes virus and poliovirus Kaij-a-Kamb et al (1992) 5,7,3,3′,4,5-Hexahydroxyflavone, and 5,7,4′-Trihydroxy-3-glycosylflavone Befaria cinnamomea ...…”

Section: Antivirals From Natural Sourcesmentioning

confidence: 99%

Emerging paradigms of viral diseases and paramount role of natural resources as antiviral agents

Jansi¹,

Khusro²,

Agastian³

et al. 2021

Science of The Total Environment

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In the current scenario, the increasing prevalence of diverse microbial infections as well as emergence and re-emergence of viral epidemics with high morbidity and mortality rates are major public health threat. Despite the persistent production of antiviral drugs and vaccines in the global market, viruses still remain as one of the leading causes of deadly human diseases. Effective control of viral diseases, particularly Zika virus disease, Nipah virus disease, Severe acute respiratory syndrome, Coronavirus disease, Herpes simplex virus infection, Acquired immunodeficiency syndrome, and Ebola virus disease remain promising goal amidst the mutating viral strains. Current trends in the development of antiviral drugs focus solely on testing novel drugs or repurposing drugs against potential targets of the viruses. Compared to synthetic drugs, medicines from natural resources offer less side-effect to humans and are often cost-effective in the productivity approaches. This review intends not only to emphasize on the major viral disease outbreaks in the past few decades and but also explores the potentialities of natural substances as antiviral traits to combat viral pathogens. Here, we spotlighted a comprehensive overview of antiviral components present in varied natural sources, including plants, fungi, and microorganisms in order to identify potent antiviral agents for developing alternative therapy in future.

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Section: Antivirals From Natural Sourcesmentioning

confidence: 99%

Emerging paradigms of viral diseases and paramount role of natural resources as antiviral agents

Jansi¹,

Khusro²,

Agastian³

et al. 2021

Science of The Total Environment

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“…Subsequently, M. Hirota, R. Irie, and co‐workers isolated the compound together with other flavonoids (Azobechalcones) from the lophira alata , a medicinal plant in tropical West Africa. Lophirone F shows inhibitory activities (18 %) against Epstein–Barr virus (EBV) and early antigen (EA) induction by a tumor promoter, teleocidin B‐4 (50 n m ) . The natural product possesses a complex structure which contains four contiguous tertiary stereogenic carbons, in a 2,5‐diaryl‐3,4‐disubstituted tetrahydrofuran skeleton as well as four aromatic rings with six phenolic O–H groups.…”

Section: Figurementioning

confidence: 99%

Total Synthesis of Lophirone F Hexamethyl Ether

Mac

et al. 2019

Eur J Org Chem

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A practical and efficient approach for the total synthesis of the (±)‐lophirone F hexamethyl ether was reported. The compound was synthesized in 8 steps with a 14.6 % overall yield. The key features of this synthesis are the stereoselective synthesis of a 2,5‐diaryl‐3,4‐disubstituted tetrahydrofuran skeleton via a sequence of [3+2] cycloaddition/Krapcho decarboxylation and the installation of two aryl ketone groups bypassing potential epimerization of adjacent stereocenters.

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“…Its medicinal usage includes; anti-inflammatory, antimicrobial and analgesic activity. [11] The stem bark is rich in chalcones of varying structures ranging from mono -hexa-chalcones. The isolated chalcones include; lophirone A-H, bongosin, mbamichalcone, tetraflavonoids among others.…”

Section: Wwwantioxorgmentioning

confidence: 99%

Electrophilic, Free Radical and Reactive Oxygen Species Scavenging and Detoxification Potentials of Lophiraalata Stem Bark Extract

Ajiboye

Yakubu

Oladiji

2011

Free Radicals and Antioxidants

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The electrophilic, free radical and reactive oxygen species scavenging and detoxification potentials of Lophiraalata stem bark was evaluated. L. alata stem bark effectively scavenged DPPH radical, superoxideion and hydrogen peroxide. It produced 88% scavenging effect of DPPH radical at a concentration of 1.0 mg/ml. Aqueous extract of L. alata-stem bark produced 76% and 92% scavenging effect on superoxide ion and hydrogen peroxide respectively at 1.0 mg/ml, which compared favourably with the synthetic antioxidant (butylated hydroanisole and α-tocopherol). A reducing power of L. alata stem bark was examined using K 3 Fe(CN) 6 , 2-folds reducing power potentials was exhibited by L. alata stem bark when compared with the synthetic antioxidant,butylated hydroanisole. Reactive oxygen species detoxify enzymes; superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GRed) were significantly induced by 90, 133, 90 and 172% respectively. While the electrophilic detoxifying enzymes NADPH: quinone oxidoreductase-1 (NQO1), uridyl diphosphoglucuronosyl transferase (UGT), glutathione S-transferase (GST) and epoxide hydrolase (EPh)) were induced by 240, 81, 196 and 281% respectively at the end of the experimental period. In view of these properties, L. alata can act as a prophylactic by intervening as electrophilic, free radical and ROS scavenger and detoxifier. IntroductIonFree radicals, specifically reactive oxygen species (ROS), are formed by several different mechanisms. ROS are oxygen ions [singlet oxygen, superoxide (O 2 ·)] or oxygen-containing radicals [hydroxyl, (OH·)]. They are generated in response to both endogenous and exogenous stimuli.[1,2,3] ROS and their reaction products [e.g. hydrogen peroxide (H 2 O 2 )] are increasingly recognized as signaling intermediates contributing to adaptive or maladaptive molecular responses.[4] Under physiological concentrations, ROS act as signaling molecules mediating cell growth, migration and differentiation, [5] whereas at higher concentrations, they induce cell death, apoptosis and senescence. [5] Accumulative ROS production is suggested to stimulate oncogenesis via alterations in redox regulated signaling pathways suggesting that the redox state plays a critical Electrophilic, Free radical and reactive oxygen Species Scavenging and detoxification Potentials of Lophiraalata Stem Bark ExtractTaofeek Olakunle Ajiboye, Musa Toyin Yakubu, Adenike Temidayo Oladiji Antioxidant, Free Radical, Cellular and Molecular Toxicology Laboratory, Biochemistry Department, University of Ilorin, Ilorin, Nigeria role in signal transduction, cellular proliferation, differentiation and apoptosis. [5,6] Multiple pathways involved in ROS-induced cell death have been proposed. ROS can cause direct injury to proteins, lipids, and nucleic acids, leading to cell death. For example, protein oxidation and nitrosylation (carbonyl, nitration, and nitrotyrosine formation) can impair a wide variety of enzymatic processes and growth factors that can result i...

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Possible anti-tumour promoters: BI- and tetraflavonoids from Lophira alata

Cited by 28 publications

References 10 publications

Emerging paradigms of viral diseases and paramount role of natural resources as antiviral agents

Emerging paradigms of viral diseases and paramount role of natural resources as antiviral agents

Total Synthesis of Lophirone F Hexamethyl Ether

Electrophilic, Free Radical and Reactive Oxygen Species Scavenging and Detoxification Potentials of Lophiraalata Stem Bark Extract

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