Possible Applications of Recombinant DNA Technology to the Diagnosis and Study of Variants of α₁-Antitrypsin

Abstract

SUMMARY.We describe the basic principles of recombinant DNA technology and how this methodology has been used to isolate and characterise cloned genes coding for ai-antitrypsin. We show how these probes can be used for diagnosis and to study molecular variants of ai-antitrypsin which may predispose individuals to develop lung disease.