Possible association between vitamin B12 deficiency and restless legs syndrome

Geng, Chaofan; Yang, Zhenzhen; Xu, Pengfei; Zhang, Hongju

doi:10.1016/j.clineuro.2022.107477

Cited by 8 publications

(9 citation statements)

References 43 publications

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“…Geng et al identified an independent association between decreased serum vitamin B12 levels and the development of RLS. The authors hypothesized that vitamin B12 may be related to dopamine dysfunction mechanisms in RLS [29]. But more research is needed to see the relation.…”

Section: Discussionmentioning

confidence: 99%

“…RLS during pregnancy is linked to gestational hypertension, preeclampsia, poor sleep and quality of life, daytime lethargy, and depression. History of RLS before conception, RLS during a previous pregnancy, coffee consumption before conception, peptic ulcer disease, hemoglobin < 11 g/dL, and inadequate supplementation of iron and folate during pregnancy, especially when iron deficiency is present, have been identified as risk factors for the development of RLS during pregnancy [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%

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The Prevalence, Severity, and Predictive Factors of Restless Legs Syndrome in Pregnancy

Turan,

Aşkın Turan,

Butun

et al. 2023

Cureus

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Objectives: The current study aimed to search the prevalence and severity of restless legs syndrome (RLS) in pregnancy according to the three trimesters and predictive factors of RLS in pregnancy based on validated diagnostic tools and a thorough literature review.Methods: The cross-sectional descriptive study included 500 pregnant women without comorbidities who were interviewed face-to-face. Age, height, weight, week of pregnancy, smoking, alcohol, caffeine use, regular exercise, and lab test results from the last visit were all included in the data. Only women satisfying the RLS diagnostic criteria were given the Restless Legs Syndrome Rating Scale.Results: The prevalence of RLS was found to be 29.2% with the highest rate in the third trimester (64.4%). In all trimesters, low ferritin (first trimester: p = 0.004; second trimester: p < 0.001; third trimester: p < 0.001), folic acid (first trimester: p = 0.001; second trimester: p < 0.001; third trimester: p < 0.001), vitamin B12 (first trimester: p = 0.003; second trimester: p < 0.001; third trimester: p < 0.001), and hemoglobin (first trimester: p < 0.001; second trimester: p < 0.001; third trimester: p < 0.001) levels were associated with RLS. In the second and third trimesters, low magnesium (p < 0.001 and p < 0.001, respectively) and high creatinine (p = 0.027 and p < 0.001, respectively) levels were associated with RLS. Higher thyroid-stimulating hormone and free T4 levels were associated with RLS in the third trimester but not in the first and second trimesters (median: 2.4 vs.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Prevalence, Severity, and Predictive Factors of Restless Legs Syndrome in Pregnancy

Turan,

Aşkın Turan,

Butun

et al. 2023

Cureus

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“…Of individuals with conditions associated with iron-deficiency states, including pregnancy, renal failure, and anemia, 25–30% of them may develop RLS [ 13 ]. Patients with RLS could be deficient in vitamins D and B12 [ 14 , 15 ]. Various comorbidities such as kidney disease, cardiovascular diseases, diabetes mellitus, hypothyroidism, chronic liver disease, and neurological, rheumatological and respiratory disorders accompany RLS [ 2 , 16 , 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Correlates of Restless Legs Syndrome in Older People

Szklarek,

Kostka,

Kostka

2024

JCM

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Background: We examined the association between restless legs syndrome (RLS) and comprehensive geriatric assessment (CGA) data in two older European populations. The second goal was to evaluate correlates of their quality of life (QoL). Methods: Diagnostic criteria of the International RLS Study Group (IRLSSG) and elements of CGA were used in this study. Results: Among the examined 246 participants, 77 (31.3%) suffered from RLS, more often in the UK (39.4%) than in Poland (25.4%) (p = 0.019). In the multivariate logistic regression model, female sex [OR (CI) = 3.29 (1.51–7.21); p = 0.0014], the number of medications per day [OR (CI) = 1.11 (1.02–1.20); p = 0.011] and alcohol consumption [OR (CI) = 5.41 (2.67–10.95); p < 0.001] increased the probability of RLS. Residing in Poland [OR (CI) = 3.06 (1.36–6.88); p = 0.005], the presence of RLS [OR (CI) = 2.90 (1.36–6.17); p = 0.004], chronic heart failure, [OR (CI) = 3.60 (1.75–7.41); p < 0.001], osteoarthritis [OR (CI) = 2.85 (1.47–5.49); p = 0.0016], and urinary incontinence [OR (CI) = 4.74 (1.87–11.9); p < 0.001] were associated with a higher probability of mobility dimension problems in the QoL. Higher physical activity was related to a lower probability of mobility problems [OR (CI) = 0.85 (0.78–0.92); p < 0.001]. Conclusions: female sex, the number of medications and alcohol consumption are independent correlates of RLS in older adults. RLS together with several chronic medical conditions and a low physical activity level were independent correlates of the mobility dimension of the QoL.

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“…The postulated mechanisms include iron deficiency, dopaminergic dysfunction, single nucleotide polymorphisms in RLS risk specific genes. 3 Neuropsychiatric manifestations commonly associated with vitamin B12 deficiency include myelopathy, neuropathy and cognitive impairment. Furthermore, vitamin B12 deficiency coupled with elevated homocysteine has been linked with neurodegenerative diseases.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, vitamin B12 deficiency coupled with elevated homocysteine has been linked with neurodegenerative diseases. 2,3 However, the studies focusing on vitamin B12 deficiency as a causative factor for development of RLS are scarce. We describe a patient with RLS as the sole presenting feature of vitamin B12 deficiency which showed complete resolution with vitamin B12 supplementation alone.…”

Section: Introductionmentioning

confidence: 99%

Establishing the Law of Parsimony in a Case of Restless Legs Syndrome

Jha,

Pendyala,

Mahale

2024

J Sleep Med

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Restless legs syndrome (RLS) is a common movement disorder characterized by uncomfortable sensations in the lower limbs relieved by limb movements. Clinical studies have established a possible association between RLS and vitamin B12 deficiency but not a causal one. RLS has rarely been reported as an isolated neurological manifestation of vitamin B12 deficiency. In this case report, we described a 24-year-old young man with RLS who responded poorly to symptomatic therapy. The etiological evaluation suggested vitamin B12 deficiency secondary to pernicious anemia. The patient responded rapidly to vitamin B12 supplementation and clinical manifestations of RLS resolved, suggesting a possible causal relationship.

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Possible association between vitamin B12 deficiency and restless legs syndrome

Cited by 8 publications

References 43 publications

The Prevalence, Severity, and Predictive Factors of Restless Legs Syndrome in Pregnancy

The Prevalence, Severity, and Predictive Factors of Restless Legs Syndrome in Pregnancy

Correlates of Restless Legs Syndrome in Older People

Establishing the Law of Parsimony in a Case of Restless Legs Syndrome

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