Possible Binding of Piperine in Mycobacterium tuberculosis RNA Polymerase and Rifampin Synergism

Murase, Letícia Sayuri; Souza, João Vítor Perez de; Meneguello, Jean Eduardo; Seixas, Flávio Augusto Vicente; Hegeto, Laíse Adriane; Scodro, Regiane Bertin de Lima; Siqueira, Vera Lúcia Dias; Ferracioli, Katiany Rizzieri Caleffi; Cardoso, Rosilene Fressatti

doi:10.1128/aac.02520-18

Cited by 9 publications

(4 citation statements)

References 29 publications

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“…87 Piperine is efficient against the multidrug‐resistant strains along with eliminating drug‐sensitive strains. 88 Chabamide is a dimer of piperine and is isolated from the stems of P. chaba . This dimer exhibits antituberculosis activity against M. tuberculosis .…”

Section: Phytochemicals Used In Tuberculosis Therapy With Their Potential Role In Attmentioning

confidence: 99%

Advances in adjunct therapy against tuberculosis: Deciphering the emerging role of phytochemicals

Fatima

Kumari

Dwivedi

2021

MedComm

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Eastern countries are a major source of medicinal plants, which set up a rich source of ethnopharmacologically known medicines used in the treatment of various diseases. These traditional medicines have been known as complementary, alternative, or nonconventional therapy across globe for ages. Tuberculosis (TB) poses a huge global burden and leads to maximum number of deaths due to an infectious agent. Treatment of TB using Directly Observed Treatment Short‐course (DOTS) therapy comprises multiple antibiotics is quite lengthy and causes serious side‐effects in different organs. The length of the TB treatment leads to withdrawal from the patients, which paves the way for the emergence of drug resistance in the bacterial population. These concerns related to therapy need serious and immediate interventions. Traditional medicines using phytochemicals has shown to provide tremendous potential in TB treatment, mainly in the eradication of Mycobacterium tuberculosis ( M.tb ), increasing natural immunity, and managing the side effects of anti‐TB drugs. This review describes the antituberculosis potential of selected ethnopharmacologically important phytochemicals as potential immune‐modulator and as an adjunct‐therapy in TB. This review will be a useful reference for researchers working on ethnopharmacology and will open the door for the discovery of novel agents as an adjunct‐therapy to tuberculosis.

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Section: Phytochemicals Used In Tuberculosis Therapy With Their Potential Role In Attmentioning

confidence: 99%

Advances in adjunct therapy against tuberculosis: Deciphering the emerging role of phytochemicals

Fatima

Kumari

Dwivedi

2021

MedComm

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“…This phenomenon causes the synergistic activity of RIF and piperine and showed how piperine clears the RIF‐resistant M.tb strain (Murase et al . 2019). Therefore, it is clear that piperine has an important role in efflux pump inhibition and it can help in different drug‐resistant M.tb treatment.…”

Section: Ethnomedicinal Plants Of India and Their Key Bioactive Molecules On Tb Managementmentioning

confidence: 99%

Potent anti‐mycobacterial and immunomodulatory activity of some bioactive molecules of Indian ethnomedicinal plants that have the potential to enter in TB management

et al. 2021

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Tuberculosis (TB), is one of the deadliest infectious-diseases of human-civilization. Approximately one-third of global-population is latently-infected with the TB-pathogen Mycobacterium tuberculosis (M.tb). The discovery of anti-TB antibiotics leads to decline in death-rate of TB. However, the evolution of antibiotic-resistant, M.tb-strain, and the resurgence of different immune compromised diseases re-escalated the death-rate of TB. WHO has already cautioned about the chances of pandemic-situation in TB endemic countries unless the discovery of new antitubercular drugs, i.e., the need of the hour. Analysing the pathogenesis of TB it was found that M.tb evades the host by altering the balance of immune-response and affects either by killing the cells or by creating inflammation. In the preantibiotic era, traditional medicines were only therapeutic measures for different infectious-diseases including tuberculosis. The ancient-literatures of India or ample Indian traditional knowledge and ethnomedicinal-practices are evidence for the treatment of TB using different indigenous plants. However, in the light of modern scientific approach, anti-TB effects of those plants and their bioactive-molecules were not established thoroughly. In this review, focus has been given on five bioactive-molecules of different traditionally used Indian ethnomedicinal plants for treatment of TB or TB-like symptom. These compounds are also validated with proper identification and their mode of action with modern scientific approaches. The effectiveness of these molecules for sensitive or drug-resistant TB-pathogen in clinical or preclinical studies were also evaluated. Thus, our specific aim is to highlight such scientifically validated bioactive compounds having anti-mycobacterial and immuno-modulatory activity for future use as medicine or adjunct-therapeutic molecule for TB management.

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“…Typically, over 80% of rifampicin-resistant strains are also resistant to isoniazid, so rifampicin resistance is gradually becoming a marker of multidrug-resistant tuberculosis. 3 The treatment of drug-resistant TB is more complicated and requires a longer regimen than that of drug-sensitive TB. Drug-resistant TB is a challenge to the prevention and control of TB worldwide, especially in low- and middle-income countries.…”

Section: Introductionmentioning

confidence: 99%

Trends of Rifampicin Resistance in Patients with Pulmonary Tuberculosis: A Longitudinal Analysis Based on Drug Resistance Screening in Eastern China Between 2015 and 2019

Ren

Chen

Zhao

et al. 2022

IDR

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To understand the trend of overall rifampicin resistance rates for tuberculosis in Zhejiang Province between 2015 and 2019. Methods: The basic demographic information of patients with tuberculosis who were screened for drug resistance in Zhejiang Province between January 1, 2015 and December 31, 2019 was collected through the national Tuberculosis Information Management System. The data were processed and analyzed using IBM SPSS 26.0 and GeoDa 1.14 software. Results:The total rifampicin resistance rate was 5.9% in 53,893 validated cases of drug resistance screening conducted in patients with pulmonary tuberculosis in Zhejiang Province during the study period. There was a decreasing trend in the rifampicin resistance rate in both initial and re-treated patients (P<0.001), but the rifampicin resistance rate was higher in re-treated TB patients than in TB patients receiving their initial treatment (11.4% vs 4.2%). The rate of drug resistance steadily decreased in all prefectures, and there was a significant upward trend in the use of the Xpert MTB/RIF rapid assay. An increasing trend was also identified in the rate of rifampicin and ofloxacin co-resistance (P<0.001). Conclusion:The overall rate of rifampin resistance in patients with tuberculosis in Zhejiang Province in the past five years has shown a decreasing trend, but the rate of resistance to ofloxacin was high. Resistance testing to fluoroquinolones should be carried out as early as possible in patients whose diagnosis results indicate rifampin resistance, and more effective second-line treatment plans should be developed based on the results of this testing.

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Possible Binding of Piperine in Mycobacterium tuberculosis RNA Polymerase and Rifampin Synergism

Cited by 9 publications

References 29 publications

Advances in adjunct therapy against tuberculosis: Deciphering the emerging role of phytochemicals

Advances in adjunct therapy against tuberculosis: Deciphering the emerging role of phytochemicals

Potent anti‐mycobacterial and immunomodulatory activity of some bioactive molecules of Indian ethnomedicinal plants that have the potential to enter in TB management

Trends of Rifampicin Resistance in Patients with Pulmonary Tuberculosis: A Longitudinal Analysis Based on Drug Resistance Screening in Eastern China Between 2015 and 2019

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