Possible effects of antioxidant status on increased platelet aggregation in childhood iron‐deficiency anemia

Tekin, Demet; Yavuzer, Sema; Tekin, Mustafa; Akar, Nejat; Cin, Şükrü

doi:10.1046/j.1442-200x.2001.01329.x

Cited by 59 publications

(43 citation statements)

References 18 publications

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“…In fact, patients with iron deficiency anemia who have no thrombocytosis can also be complicated by disturbance of retinochoroidal circulation. In addition, the functions of platelets such as aggregation activity can be altered in patients with iron deficiency anemia (13)(14)(15)(16). In the present case, almost normal prothrombin time (12.6 seconds) and activated partial thromboplastin time (26.2 seconds) were demonstrated at the time of diagnosis, suggesting that deregulation of the coagulation-fibrinolysis system was not mainly involved in the disturbance of retinochoroidal circulation.…”

Section: Discussionmentioning

confidence: 48%

Iron Deficiency Anemia with Marked Thrombocytosis Complicated by Central Retinal Vein Occlusion

et al. 2005

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We report a case of severe iron deficiency anemia with marked thrombocytosis that was complicated by central retinal vein occlusion. Platelet count was over one million per microliter and an increased number of megakaryocytes was observed in the bone marrow at the time of diagnosis of iron deficiency anemia, features that resemble those of essential thrombocythemia. However, the platelet count rapidly declined with the administration of ferrous fumarate. Accordingly, central retinal vein occlusion was improved and has not recurred. In this case, significant thrombocytosis caused by iron deficiency anemia may have been involved in the development of central retinal vein occlusion.

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Section: Discussionmentioning

confidence: 48%

Iron Deficiency Anemia with Marked Thrombocytosis Complicated by Central Retinal Vein Occlusion

et al. 2005

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“…Oxidant levels and antioxidant enzyme activities such as SOD, GSH-Px and CAT have been evaluated in several studies [8][9][10][11][12][13][14]. Although conflicting results have been reported [8,10], it is generally accepted that oxidative stress is increased through increase in oxidant levels and/or decrease in antioxidant enzyme capacities in IDA.…”

Section: Discussionmentioning

confidence: 99%

“…Increased oxidative stress in IDA subjects was reported in several studies, in which the oxidative status was evaluated using measurement of oxidants, individual antioxidants, or both [8][9][10][11][12][13][14]. In these studies, it has been reported that oxidants were increased and antioxidants were decreased, and as a result, the oxidative/anti-oxidative balance shifted toward the oxidative side in patients with IDA.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of oxidative status in iron deficiency anemia through total antioxidant capacity measured using an automated method

Aslan¹,

Horoz²,

Çelik³

2011

Turk J Hematol

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Objective: Oxidative stress, an increase in oxidants and/or a decrease in antioxidant capacity, is one of the potential biochemical mechanisms involved in the pathogenesis of iron deficiency anemia. The objective of this study was to evaluate the oxidative status and to determine whether there is any relationship between oxidative status and the severity of anemia in patients with iron deficiency anemia using an automated method. Materials and Methods: Twenty-six subjects with iron deficiency anemia and 20 healthy controls were enrolled in the present study. Serum total antioxidant capacity, serum total peroxide level and oxidative stress index were determined in all study subjects. Results: Serum total antioxidant capacity was significantly lower in patients with iron deficiency anemia than controls (p<0.05), while serum total peroxide level and oxidative stress index were significantly higher (both p<0.05). There was a significant correlation between hemoglobin level and serum total peroxide level, oxidative stress index and total antioxidant capacity (r=-0.504, p<0.05; r=-0.503, p<0.05; r=0.417, p<0.05, respectively). Conclusion: Increased oxidative stress may play a role in the pathogenesis of iron deficiency anemia. Supplementation of antioxidant vitamins in conjunction with iron replacement therapy may offer better responses and provide early resolution of symptoms related to iron deficiency anemia. The automated assay is a reliable and easily applied method for measurement of serum total antioxidant capacity in iron deficiency anemia. (Turk J Hematol 2011; 28: 42-6)

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“…Recently, Bilic and Bilic have reported that the amino acid sequence homology of thrombopoietin and erythropoietin may explain the thrombocytosis in children with iron deficiency anemia [61]. In addition to the increased thrombotic risk associated with high platelet count, other possible mechanisms suggested is decrease in antioxidant defence in iron deficiency anemia leading to increased oxidant stress, which in turn may result in a tendency toward platelet aggregation [62]. Reduced deformability and increased viscosity of microcytic red blood cells in iron deficiency may be contributory by affecting blood flow patterns within the vessels [55].…”

Section: Ida and Thrombosismentioning

confidence: 99%

Iron Deficiency: Beyond Anemia

Yadav

Chandra

2010

Indian J Pediatr

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Iron deficiency is the most common nutritional disorder affecting at least one third of world's population. Though anemia is common manifestation of iron deficiency, other effects of iron deficiency on various tissues, organs and systems are usually under recognized. Impaired brain development and cognitive, behavioural and psychomotor impairment are most worrisome manifestations of iron deficiency. Studies have demonstrated that some of these changes occurring during period of brain growth spurt (<2 years age) may be irreversible. Association of iron deficiency with febrile seizures, pica, breath holding spells, restless leg syndrome and thrombosis is increasingly being recognized. Impaired cell-mediated immunity and bactericidal function are generally noted in iron-deficient persons; however, the findings are inconsistent. Despite proven reversible functional immunological defects in vitro studies, a clinically important relationship between states of iron deficiency and susceptibility to infections remains controversial. Studies from malaria endemic regions have reported increased incidence of malaria in association with iron supplementation. These and some other aspects of iron deficiency are reviewed in this article.

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Possible effects of antioxidant status on increased platelet aggregation in childhood iron‐deficiency anemia

Abstract: Decreased antioxidant defense in IDA may cause increased oxidant stress, which, in turn, may result in a tendency towards platelet aggregation.

Cited by 59 publications

References 18 publications

Iron Deficiency Anemia with Marked Thrombocytosis Complicated by Central Retinal Vein Occlusion

Iron Deficiency Anemia with Marked Thrombocytosis Complicated by Central Retinal Vein Occlusion

Evaluation of oxidative status in iron deficiency anemia through total antioxidant capacity measured using an automated method

Iron Deficiency: Beyond Anemia

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