Possible familial origin of multifocal renal artery fibromuscular dysplasia

Abstract

Multifocal FMD was mostly found in women and unifocal FMD in young men with more severe stenosis and kidney ischemia. The documented prevalence of familial cases was 11% in this series, the true prevalence being probably higher because only a few siblings were examined by angiography. Familial cases all exhibited the multifocal type and were more commonly bilateral than were sporadic cases.

Increased severity of multifocal renal arterial fibromuscular dysplasia in smokers

“…1,16 Since smoking may accelerate progression of FMD, relatives of FMD patients should be strongly discouraged from smoking.…”

A breakthrough in spontaneous coronary artery dissection pathogenesis: is it an inherited condition?

“…The limitation of this study was that the authors included patients with atherosclerosis (coronary and peripheral arterial disease) and the conclusions were drawn from interviews of relatives with suspicion of FMD and therefore were subject to recall and other biases. Familial occurrence of FMD was noted in a study of 104 patients in which 11% of patients with renal multifocal FMD had at least one sibling with angiographic evidence of renal artery FMD [15]. The true prevalence of FMD in first-degree relatives could not be determined as not all relatives were systematically studied for FMD.…”

Nonatherosclerotic Obstructive Vascular Diseases of the Mesenteric and Renal Arteries

“…Pannier-Moreau et al 12 in 1997 conducted a retrospective analysis of 104 patients and showed a prevalence of 11% for familial cases. HLA-DRw6 10 and polymorphisms of the renin-angiotensin system are perhaps linked to FMD 13 ; however, further studies need to confirm these findings.…”