Possible functional role of substance P on the mammalian motor nerve terminals

Ganguly, Dilip; Das, Mitali; Gupta, Anand; Chauhan, S.P.S.

doi:10.1016/0024-3205(87)90345-6

Cited by 3 publications

(2 citation statements)

References 17 publications

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“…Transmitter release by Cap has been reported: the contractile response of guinea-pig ileum induced by Cap is mediated by release of SP, which in turn stimulates cholinergic nerves (Chahl, 1982;Bartho et al, 1982;Rozsa et al, 1984). Facilitation ofneuromuscular transmission by Cap has been explained as due to release of acetylcholine (Ganguly et al, 1987). Thus, it is conceivable that in rat vas deferens, Cap enhances release of an excitatory transmitter or a co-transmitter.…”

Section: Discussionmentioning

confidence: 99%

Capsaicin enhances the non‐adrenergic twitch response of rat vas deferens

Moritoki¹,

Iwamoto²,

Kanaya³

et al. 1987

British J Pharmacology

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1 Capsaicin (Cap) enhanced the twitch response of the epididymal and prostatic portions of rat vas deferens induced by field stimulation at 0.1 Hz. The effect of Cap was reproducible and showed no desensitization. 2 Prazosin, and pretreatment with reserpine or Cap did not affect the potentiating effect of Cap, whereas pretreatment with 6-hydroxydopamine abolished the action of Cap. 3 Cap tended to attenuate the contractions induced by noradrenaline, tyramine and ATP. 4 Like Cap, substance K and substance P augmented the twitch response without causing desensitization, but their effects differed somewhat from that of Cap. Calcitonin gene-related peptide inhibited the twitch response. 5 These results suggest that Cap enhances a stimulation-induced, prazosin-resistant non-adrenergic twitch response of rat vas deferens through an as yet undefined prejunctional mechanism. This mechanism is possibly mediated by some peptide released in response to Cap from sensory neurones, which in turn acts on sympathetic nerves and increases stimulation-induced release of a mediator or cotransmitter responsible for the non-adrenergic twitch response. However, the possibility that Cap has a direct action on sympathetic nerves cannot be ruled out.

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Section: Discussionmentioning

confidence: 99%

Capsaicin enhances the non‐adrenergic twitch response of rat vas deferens

Moritoki¹,

Iwamoto²,

Kanaya³

et al. 1987

British J Pharmacology

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“…So, following effects were shown: (i) facilitating effect of neuropeptide (at a concentration till 1 µM) on spontaneous and evoked quantal release of ACh [110]; (ii) reduction of the sensitivity of the postsynaptic membrane to ACh at the concentration peptide above than 1 µM [111,112]; and (iii) induction of Ca 2+ release from internal stores in Schwann cells [107]. In the mammalian NMJ also was noted presynaptic facilitatory action of substance P. Neuropeptide facilitated the indirect twitch responses of the rat diaphragm and increased amount of ACh released into the bathing medium in response to tetanic stimulation of the phrenic nerve [113].…”

Section: Peptidergic Signalingmentioning

confidence: 99%