2012
DOI: 10.1089/lrb.2011.0024
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Possible Genetic Predisposition to Lymphedema after Breast Cancer

Abstract: These provocative, albeit preliminary, findings regarding possible genetic predisposition to secondary lymphedema following breast cancer treatment warrant further attention for potential replication using larger datasets.

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Cited by 98 publications
(66 citation statements)
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“…13,14 As suggested by Newman et al, patients suffering from lymphoedema after cancer therapy probably have predisposing factors, partially genetic, which might contribute to increasing the risk of lymphoedema subsequent to treatment inducing lymphatic lesions. 17 Moreover, lymphatic function explorations in the contralateral limbs of patients with primary lymphoedema showed abnormalities indicating impaired lymphatic function. 18 Those findings might suggest more diffuse lymphatic insufficiency not localised only to the lymphoedematous limb territory.…”
Section: Discussionmentioning
confidence: 99%
“…13,14 As suggested by Newman et al, patients suffering from lymphoedema after cancer therapy probably have predisposing factors, partially genetic, which might contribute to increasing the risk of lymphoedema subsequent to treatment inducing lymphatic lesions. 17 Moreover, lymphatic function explorations in the contralateral limbs of patients with primary lymphoedema showed abnormalities indicating impaired lymphatic function. 18 Those findings might suggest more diffuse lymphatic insufficiency not localised only to the lymphoedematous limb territory.…”
Section: Discussionmentioning
confidence: 99%
“…More recently, a few studies have analyzed genetic changes in an effort to identify predisposing factors for lymphedema (22)(23)(24). Although these studies have been enormously helpful in identifying risk factors for lymphedema, clinical studies are inherently limited in identifying pathologic pathways, since this approach precludes time course analysis, provides relatively small amounts of tissues in biopsies, is confounded by patient factors, and most importantly, does not readily allow targeted interventions.…”
Section: Discussionmentioning
confidence: 99%
“…It may be influenced by genetic predisposition (73). Predisposing changes were reported in the MET gene (69) and in the GJC2 gene (74).…”
Section: Secondary Lymphedemamentioning
confidence: 99%