Possible Herpetic Viral Association in Cases of Acute Exudative Polymorphous Vitelliform Maculopathy

Abstract

We describe 2 retinopathy cases with a possible herpetic association. Methods: Presentation, workup, and clinical course of 2 patients were reviewed and compiled. Results: Patients presented with no to mild symptoms and multiple bilateral funduscopic yellow hypopigmented lesions corresponding to outer retinal thickening with submacular fluid on optical coherence tomography. Findings mimicked central serous chorioretinopathy but lacked any leakage or pooling on angiography. Systemic workups were negative and our patients had anatomic resolution following a treatment course of oral valacyclovir. Conclusion: These cases suggest a possible viral herpes zoster prodrome in some patients who present with acute exudative polymorphous vitelliform maculopathy.

Acute bilateral serous retinal detachments with spontaneous resolution in a 6-year-old boy

“…A few cases have been reported following a viral [ 5 ] or bacterial infection [ 6 ], [ 7 ], [ 8 ]. These cases were thought to be based on an autoimmune-mediated activation of inflammatory cells (presumably T lymphocytes as in Vogt-Koyanagi-Harada disease) at the level of the choroid, leading to profound choroidal swelling.…”